Pseudomonas aeruginosa PAO1, PA4663 (moeB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4663
Name
moeB
Synonym: chlN
Replicon chromosome
Genomic location 5230901 - 5231659 (- strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_253352.1
GI 15599858
Affymetrix PA4663_moeB_at
Entrez 881352
GenBank AAG08050.1
INSDC AAG08050.1
NCBI Locus Tag PA4663
protein_id(GenBank) gb|AAG08050.1|AE004880_6|gnl|PseudoCAP|PA4663
TIGR NTL03PA04664
UniParc UPI00000C5DB6
UniProtKB Acc Q9HVC9
UniProtKB ID Q9HVC9_PSEAE
UniRef100 UniRef100_Q9HVC9
UniRef50 UniRef50_Q5P7N8
UniRef90 UniRef90_V6ALN7

Product

Feature Type CDS
Coding Frame 1
Product Name
molybdopterin biosynthesis MoeB protein
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -4.77
Kyte-Doolittle Hydrophobicity Value 0.205
Molecular Weight (kDa) 26.7
Isoelectric Point (pI) 5.63

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 601 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004313 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4663
Search term: moeB

Human Homologs

Ensembl 110, assembly GRCh38.p14
molybdenum cofactor synthesis 3 [Source:HGNC Symbol;Acc:HGNC:15765]
E-value: 3.2e-55
Percent Identity: 48.6

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295