Pseudomonas aeruginosa PAO1, PA4666 (hemA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4666
Name
hemA
Synonym: hem1
Synonym: glutR
Replicon chromosome
Genomic location 5233585 - 5234853 (- strand)

Cross-References

RefSeq NP_253355.1
GI 15599861
Affymetrix PA4666_hemA_at
Entrez 881361
GenBank AAG08053.1
INSDC AAG08053.1
NCBI Locus Tag PA4666
protein_id(GenBank) gb|AAG08053.1|AE004880_9|gnl|PseudoCAP|PA4666
TIGR NTL03PA04667
UniParc UPI000012C42D
UniProtKB Acc P42807
UniProtKB ID HEM1_PSEAE
UniRef100 UniRef100_B7V0L2
UniRef50 UniRef50_Q4K694
UniRef90 UniRef90_A6VC62

Product

Feature Type CDS
Coding Frame 1
Product Name
glutamyl-tRNA reductase
Product Name Confidence: Class 1
Synonyms hemA
delta-aminolevulinic synthase
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -9.18
Kyte-Doolittle Hydrophobicity Value -0.042
Molecular Weight (kDa) 46.1
Isoelectric Point (pI) 5.63

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 517 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004316 (537 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4666
Search term: hemA

Human Homologs

References

Isolation, nucleotide sequence, and preliminary characterization of the Escherichia coli K-12 hemA gene.
Verkamp E, Chelm BK
J Bacteriol 1989 Sep;171(9):4728-35
PubMed ID: 2548996
Regulation of the hemA gene during 5-aminolevulinic acid formation in Pseudomonas aeruginosa.
Hungerer C, Troup B, Römling U, Jahn D
J Bacteriol 1995 Mar;177(6):1435-43
PubMed ID: 7883699