Pseudomonas aeruginosa PAO1, PA4679 (holD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4679
Name
holD
Replicon chromosome
Genomic location 5248071 - 5248772 (- strand)

Cross-References

RefSeq NP_253368.1
GI 15599874
Affymetrix PA4679_at
DNASU PaCD00008033
Entrez 881431
GenBank AAG08066.1
INSDC AAG08066.1
NCBI Locus Tag PA4679
protein_id(GenBank) gb|AAG08066.1|AE004881_9|gnl|PseudoCAP|PA4679
TIGR NTL03PA04680
UniParc UPI00000C5DBF
UniProtKB Acc Q9HVB6
UniProtKB ID Q9HVB6_PSEAE
UniRef100 UniRef100_Q9HVB6
UniRef50 UniRef50_Q9HVB6
UniRef90 UniRef90_Q9HVB6

Product

Feature Type CDS
Coding Frame 1
Product Name
DNA polymerase III subunit psi
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -3.05
Kyte-Doolittle Hydrophobicity Value -0.109
Molecular Weight (kDa) 24.8
Isoelectric Point (pI) 4.98

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 2 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004329 (533 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4679
Search term: holD

Human Homologs

References

Discovery and characterization of the cryptic psi subunit of the pseudomonad DNA replicase.
Jarvis TC, Beaudry AA, Bullard JM, Ochsner U, Dallmann HG, McHenry CS
J Biol Chem 2005 Dec 9;280(49):40465-73
PubMed ID: 16210315
Effect of a Defective Clamp Loader Complex of DNA Polymerase III on Growth and SOS Response in Pseudomonas aeruginosa.
Spinnato MC, Lo Sciuto A, Mercolino J, Lucidi M, Leoni L, Rampioni G, Visca P, Imperi F
Microorganisms 2022 Feb 12;10(2)
PubMed ID: 35208877