Pseudomonas aeruginosa PAO1, PA4730 (panC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4730
Name
panC
Replicon chromosome
Genomic location 5312261 - 5313112 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253418.1
GI 15599924
Affymetrix PA4730_panC_at
Entrez 881622
GenBank AAG08116.1
INSDC AAG08116.1
NCBI Locus Tag PA4730
protein_id(GenBank) gb|AAG08116.1|AE004886_8|gnl|PseudoCAP|PA4730
TIGR NTL03PA04731
UniParc UPI000013129F
UniProtKB Acc Q9HV69
UniProtKB ID PANC_PSEAE
UniRef100 UniRef100_Q02FU2
UniRef50 UniRef50_Q2LSQ5
UniRef90 UniRef90_A6VCI6

Product

Feature Type CDS
Coding Frame 1
Product Name
pantoate--beta-alanine ligase
Product Name Confidence: Class 2
Synonyms pantoate activating enzyme
pantothenate synthetase
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -1.61
Kyte-Doolittle Hydrophobicity Value -0.101
Molecular Weight (kDa) 30.8
Isoelectric Point (pI) 6.52

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 499 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004377 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4730
Search term: panC

Human Homologs

References

Pantothenate synthetase of Escherichia coli B. I. Physicochemical properties.
Miyatake K, Nakano Y, Kitaoka S
J Biochem 1976 Mar;79(3):673-8
PubMed ID: 780351