Pseudomonas aeruginosa PAO1, PA4811 (fdnH)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4811
Name
fdnH
Synonym: fdhH
Replicon chromosome
Genomic location 5397690 - 5398619 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253499.1
GI 15600005
Affymetrix PA4811_fdnH_at
Entrez 880193
GenBank AAG08197.1
INSDC AAG08197.1
NCBI Locus Tag PA4811
protein_id(GenBank) gb|AAG08197.1|AE004894_3|gnl|PseudoCAP|PA4811
TIGR NTL03PA04812
UniParc UPI00000C5E19
UniProtKB Acc Q9HUZ8
UniProtKB ID Q9HUZ8_PSEAE
UniRef100 UniRef100_Q9HUZ8
UniRef50 UniRef50_P0AAJ3
UniRef90 UniRef90_Q9HUZ8

Product

Feature Type CDS
Coding Frame 1
Product Name
nitrate-inducible formate dehydrogenase, beta subunit
Product Name Confidence: Class 2
Synonyms iron-sulfur subunit
nitrate-inducible formate dehydrogenase
Evidence for Translation
Charge (pH 7) -8.88
Kyte-Doolittle Hydrophobicity Value -0.359
Molecular Weight (kDa) 33.8
Isoelectric Point (pI) 5.97

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 2
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 420 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004447 (438 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4811
Search term: fdnH

Human Homologs

References

The purification and properties of formate dehydrogenase and nitrate reductase from Escherichia coli.
Enoch HG, Lester RL
J Biol Chem 1975 Sep 10;250(17):6693-705
PubMed ID: 1099093
Purification and properties of formate dehydrogenase from Pseudomonas aeruginosa. Characterization of haem and iron-sulphur centres by magnetic-circular-dichroism and electron-paramagnetic-resonance spectroscopy.
Godfrey C, Coddington A, Greenwood C, Thomson AJ, Gadsby PM
Biochem J 1987 Apr 1;243(1):225-33
PubMed ID: 3038081
Purification and properties of formate dehydrogenase from Pseudomonas aeruginosa. Electron-paramagnetic-resonance studies on the molybdenum centre.
Gadsby PM, Greenwood C, Coddington A, Thomson AJ, Godfrey C
Biochem J 1987 Apr 1;243(1):235-9
PubMed ID: 3038082
Electron-paramagnetic-resonance and magnetic-circular-dichroism studies on the formate dehydrogenase-nitrate reductase particle from Pseudomonas aeruginosa.
Godfrey C, Gadsby PM, Thomson AJ, Greenwood C, Coddington A
Biochem J 1987 Apr 1;243(1):241-8
PubMed ID: 3038083
Nitrate-inducible formate dehydrogenase in Escherichia coli K-12. I. Nucleotide sequence of the fdnGHI operon and evidence that opal (UGA) encodes selenocysteine.
Berg BL, Li J, Heider J, Stewart V
J Biol Chem 1991 Nov 25;266(33):22380-5
PubMed ID: 1834669