Pseudomonas aeruginosa PAO1, PA4825 (mgtA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4825
Name
mgtA
Replicon chromosome
Genomic location 5415413 - 5418124 (- strand)
Transposon Mutants 4 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253512.1
GI 15600018
Affymetrix PA4825_mgtA_at
Entrez 880401
GenBank AAG08210.1
INSDC AAG08210.1
NCBI Locus Tag PA4825
protein_id(GenBank) gb|AAG08210.1|AE004895_10|gnl|PseudoCAP|PA4825
TIGR NTL03PA04826
UniParc UPI00000C5E26
UniProtKB Acc Q9HUY5
UniProtKB ID Q9HUY5_PSEAE
UniRef100 UniRef100_Q9HUY5
UniRef50 UniRef50_B7NUF8
UniRef90 UniRef90_A6VCT0

Product

Feature Type CDS
Coding Frame 1
Product Name
Mg(2+) transport ATPase, P-type 2
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Detected using LC-MS/MS (100.05 kDa, PMID:21751344)
Charge (pH 7) -5.78
Kyte-Doolittle Hydrophobicity Value 0.118
Molecular Weight (kDa) 100.1
Isoelectric Point (pI) 6.09

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Vesicle Class 1
Cytoplasmic Membrane Class 3
Cytoplasmic Membrane Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 635 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001347 (772 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4825
Search term: mgtA

Human Homologs

Ensembl 110, assembly GRCh38.p14
ATPase secretory pathway Ca2+ transporting 1 [Source:HGNC Symbol;Acc:HGNC:13211]
E-value: 9.3e-73
Percent Identity: 26.2
Ensembl 110, assembly GRCh38.p14
ATPase secretory pathway Ca2+ transporting 1 [Source:HGNC Symbol;Acc:HGNC:13211]
E-value: 9.3e-73
Percent Identity: 26.2
Ensembl 110, assembly GRCh38.p14
ATPase secretory pathway Ca2+ transporting 1 [Source:HGNC Symbol;Acc:HGNC:13211]
E-value: 9.3e-73
Percent Identity: 26.2
Ensembl 110, assembly GRCh38.p14
ATPase secretory pathway Ca2+ transporting 1 [Source:HGNC Symbol;Acc:HGNC:13211]
E-value: 9.3e-73
Percent Identity: 26.2
Ensembl 110, assembly GRCh38.p14
ATPase secretory pathway Ca2+ transporting 1 [Source:HGNC Symbol;Acc:HGNC:13211]
E-value: 9.3e-73
Percent Identity: 26.2
Ensembl 110, assembly GRCh38.p14
ATPase secretory pathway Ca2+ transporting 1 [Source:HGNC Symbol;Acc:HGNC:13211]
E-value: 9.3e-73
Percent Identity: 26.2
Ensembl 110, assembly GRCh38.p14
ATPase secretory pathway Ca2+ transporting 1 [Source:HGNC Symbol;Acc:HGNC:13211]
E-value: 9.3e-73
Percent Identity: 26.2
Ensembl 110, assembly GRCh38.p14
ATPase secretory pathway Ca2+ transporting 1 [Source:HGNC Symbol;Acc:HGNC:13211]
E-value: 9.3e-73
Percent Identity: 26.2
Ensembl 110, assembly GRCh38.p14
ATPase secretory pathway Ca2+ transporting 1 [Source:HGNC Symbol;Acc:HGNC:13211]
E-value: 9.3e-73
Percent Identity: 26.2

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
The mgtB Mg2+ transport locus of Salmonella typhimurium encodes a P-type ATPase.
Snavely MD, Miller CG, Maguire ME
J Biol Chem 1991 Jan 15;266(2):815-23
PubMed ID: 1824701
Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa.
Choi DS, Kim DK, Choi SJ, Lee J, Choi JP, Rho S, Park SH, Kim YK, Hwang D, Gho YS
Proteomics 2011 Aug;11(16):3424-9
PubMed ID: 21751344