Pseudomonas aeruginosa PAO1, PA4845 (dipZ)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4845
Name
dipZ
Synonym: cycZ
Replicon chromosome
Genomic location 5439918 - 5441693 (+ strand)
Transposon Mutants 4 transposon mutants in PAO1
Transposon Mutants in orthologs 3 transposon mutants in orthologs

Cross-References

RefSeq NP_253532.1
GI 15600038
Affymetrix PA4845_dipZ_at
Entrez 879570
GenBank AAG08230.1
INSDC AAG08230.1
NCBI Locus Tag PA4845
protein_id(GenBank) gb|AAG08230.1|AE004898_1|gnl|PseudoCAP|PA4845
TIGR NTL03PA04846
UniParc UPI00001298FC
UniProtKB Acc Q9HUW5
UniProtKB ID DSBD1_PSEAE
UniRef100 UniRef100_Q9HUW5
UniRef50 UniRef50_Q9HUW5
UniRef90 UniRef90_Q9HUW5

Product

Feature Type CDS
Coding Frame 1
Product Name
thiol:disulfide interchange protein DipZ
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 4.47
Kyte-Doolittle Hydrophobicity Value 0.363
Molecular Weight (kDa) 62.9
Isoelectric Point (pI) 8.26

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 1
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 315 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003075 (942 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4845
Search term: dipZ

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Disruption of the Pseudomonas aeruginosa dipZ gene, encoding a putative protein-disulfide reductase, leads to partial pleiotropic deficiency in c-type cytochrome biogenesis.
Page MD, Saunders NFW, Ferguson SJ
Microbiology (Reading) 1997 Oct;143 ( Pt 10):3111-3112
PubMed ID: 9353916