Pseudomonas aeruginosa PAO1, PA4848 (accC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4848
Name
accC
Replicon chromosome
Genomic location 5442792 - 5444141 (+ strand)

Cross-References

RefSeq NP_253535.1
GI 15600041
Affymetrix PA4848_accC_at
Entrez 879558
GenBank AAG08233.1
INSDC AAG08233.1
NCBI Locus Tag PA4848
protein_id(GenBank) gb|AAG08233.1|AE004898_4|gnl|PseudoCAP|PA4848
TIGR NTL03PA04849
UniParc UPI00001251AF
UniProtKB Acc P37798
UniProtKB ID ACCC_PSEAE
UniRef100 UniRef100_P37798
UniRef50 UniRef50_P37798
UniRef90 UniRef90_P37798

Product

Feature Type CDS
Coding Frame 1
Product Name
biotin carboxylase
Product Name Confidence: Class 1
Synonyms acetyl-CoA carboxylase
Evidence for Translation
Detected by MALDI-TOF/TOF (PMID:19333994).
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -5.82
Kyte-Doolittle Hydrophobicity Value -0.183
Molecular Weight (kDa) 48.9
Isoelectric Point (pI) 6.28

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2C00 LIGASE 03/21/08 Crystal Structure of Biotin Carboxylase from Pseudomonas aeruginosa in apo form PSEUDOMONAS AERUGINOSA 2.5 X-RAY DIFFRACTION 100.0
2VQD LIGASE 03/13/08 Crystal Structure of Biotin Carboxylase from Pseudomonas aeruginosa complexed with AMPCP PSEUDOMONAS AERUGINOSA 2.41 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 630 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004477 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4848
Search term: accC

Human Homologs

Ensembl 110, assembly GRCh38.p14
propionyl-CoA carboxylase subunit alpha [Source:HGNC Symbol;Acc:HGNC:8653]
E-value: 5.0e-120
Percent Identity: 47.5
Ensembl 110, assembly GRCh38.p14
propionyl-CoA carboxylase subunit alpha [Source:HGNC Symbol;Acc:HGNC:8653]
E-value: 5.0e-120
Percent Identity: 47.5
Ensembl 110, assembly GRCh38.p14
propionyl-CoA carboxylase subunit alpha [Source:HGNC Symbol;Acc:HGNC:8653]
E-value: 5.0e-120
Percent Identity: 47.5

References

Acetyl-CoA carboxylase from Escherichia coli: gene organization and nucleotide sequence of the biotin carboxylase subunit.
Kondo H, Shiratsuchi K, Yoshimoto T, Masuda T, Kitazono A, Tsuru D, Anai M, Sekiguchi M, Tanabe T
Proc Natl Acad Sci U S A 1991 Nov 1;88(21):9730-3
PubMed ID: 1682920
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994