Pseudomonas aeruginosa PAO1, PA4868 (ureC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4868
Name
ureC
Replicon chromosome
Genomic location 5464821 - 5466521 (+ strand)
Transposon Mutants 5 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253555.1
GI 15600061
Affymetrix PA4868_ureC_at
Entrez 878240
GenBank AAG08253.1
INSDC AAG08253.1
NCBI Locus Tag PA4868
protein_id(GenBank) gb|AAG08253.1|AE004900_7|gnl|PseudoCAP|PA4868
TIGR NTL03PA04869
UniParc UPI00000C5E4A
UniProtKB Acc Q9HUU5
UniProtKB ID URE1_PSEAE
UniRef100 UniRef100_Q9HUU5
UniRef50 UniRef50_P50047
UniRef90 UniRef90_Q9HUU5

Product

Feature Type CDS
Coding Frame 1
Product Name
urease alpha subunit
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -8.62
Kyte-Doolittle Hydrophobicity Value -0.062
Molecular Weight (kDa) 60.6
Isoelectric Point (pI) 6.20

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Cytoplasmic Class 1
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 240 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004496 (523 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4868
Search term: ureC

Human Homologs

References

Sequence of the Klebsiella aerogenes urease genes and evidence for accessory proteins facilitating nickel incorporation.
Mulrooney SB, Hausinger RP
J Bacteriol 1990 Oct;172(10):5837-43
PubMed ID: 2211515
The crystal structure of urease from Klebsiella aerogenes.
Jabri E, Carr MB, Hausinger RP, Karplus PA
Science 1995 May 19;268(5213):998-1004
PubMed ID: 7754395