Pseudomonas aeruginosa PAO1, PA5063 (ubiE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5063
Name
ubiE
Replicon chromosome
Genomic location 5702669 - 5703439 (+ strand)

Cross-References

RefSeq NP_253750.1
GI 15600256
Affymetrix PA5063_ubiE_at
Entrez 879743
GenBank AAG08448.1
INSDC AAG08448.1
NCBI Locus Tag PA5063
protein_id(GenBank) gb|AAG08448.1|AE004919_9|gnl|PseudoCAP|PA5063
TIGR NTL03PA05064
UniParc UPI00000C5EE4
UniProtKB Acc Q9HUC0
UniProtKB ID UBIE_PSEAE
UniRef100 UniRef100_B7V3F6
UniRef50 UniRef50_Q8P558
UniRef90 UniRef90_B7V3F6

Product

Feature Type CDS
Coding Frame 1
Product Name
ubiquinone biosynthesis methyltransferase UbiE
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 5.89
Kyte-Doolittle Hydrophobicity Value -0.248
Molecular Weight (kDa) 28.3
Isoelectric Point (pI) 9.50

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 602 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004664 (537 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5063
Search term: ubiE

Human Homologs

Ensembl 110, assembly GRCh38.p14
coenzyme Q5, methyltransferase [Source:HGNC Symbol;Acc:HGNC:28722]
E-value: 1.1e-63
Percent Identity: 45.1

References

A C-methyltransferase involved in both ubiquinone and menaquinone biosynthesis: isolation and identification of the Escherichia coli ubiE gene.
Lee PT, Hsu AY, Ha HT, Clarke CF
J Bacteriol 1997 Mar;179(5):1748-54
PubMed ID: 9045837