Pseudomonas aeruginosa PAO1, PA5141 (hisA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5141
Name
hisA
Replicon chromosome
Genomic location 5789395 - 5790132 (- strand)
Transposon Mutants 6 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_253828.1
GI 15600334
Affymetrix PA5141_hisA_at
DNASU PaCD00008212
Entrez 878542
GenBank AAG08526.1
INSDC AAG08526.1
NCBI Locus Tag PA5141
protein_id(GenBank) gb|AAG08526.1|AE004927_4|gnl|PseudoCAP|PA5141
TIGR NTL03PA05142
UniParc UPI000012C7D5
UniProtKB Acc Q9HU43
UniProtKB ID HIS4_PSEAE
UniRef100 UniRef100_A6VDR0
UniRef50 UniRef50_Q7P0F0
UniRef90 UniRef90_A6VDR0

Product

Feature Type CDS
Coding Frame 1
Product Name
phosphoribosylformimino-5-aminoimidazole carboxamide
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -7.43
Kyte-Doolittle Hydrophobicity Value 0.195
Molecular Weight (kDa) 25.9
Isoelectric Point (pI) 4.72

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 2
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 581 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004733 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5141
Search term: hisA

Human Homologs

References

Structure and function of the Salmonella typhimurium and Escherichia coli K-12 histidine operons.
Carlomagno MS, Chiariotti L, Alifano P, Nappo AG, Bruni CB
J Mol Biol 1988 Oct 5;203(3):585-606
PubMed ID: 3062174