Pseudomonas aeruginosa PAO1, PA5165 (dctB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5165
Name
dctB
Replicon chromosome
Genomic location 5813727 - 5815565 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253852.1
GI 15600358
Affymetrix PA5165_at
Entrez 879962
GenBank AAG08550.1
INSDC AAG08550.1
NCBI Locus Tag PA5165
protein_id(GenBank) gb|AAG08550.1|AE004929_5|gnl|PseudoCAP|PA5165
TIGR NTL03PA05166
UniParc UPI00000C5F32
UniProtKB Acc Q9HU20
UniProtKB ID Q9HU20_PSEAE
UniRef100 UniRef100_Q9HU20
UniRef50 UniRef50_Q9HU20
UniRef90 UniRef90_Q9HU20

Product

Feature Type CDS
Coding Frame 1
Product Name
DctB
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 7.61
Kyte-Doolittle Hydrophobicity Value -0.191
Molecular Weight (kDa) 68.5
Isoelectric Point (pI) 9.23

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 2
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 605 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004756 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5165
Search term: dctB
Search term: DctB

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Conservation between coding and regulatory elements of Rhizobium meliloti and Rhizobium leguminosarum dct genes.
Jiang J, Gu BH, Albright LM, Nixon BT
J Bacteriol 1989 Oct;171(10):5244-53
PubMed ID: 2793824
Genetic analysis and regulation of the Rhizobium meliloti genes controlling C4-dicarboxylic acid transport.
Wang YP, Birkenhead K, Boesten B, Manian S, O'Gara F
Gene 1989 Dec 21;85(1):135-44
PubMed ID: 2695394
Identification of C(4)-dicarboxylate transport systems in Pseudomonas aeruginosa PAO1.
Valentini M, Storelli N, Lapouge K
J Bacteriol 2011 Sep;193(17):4307-16
PubMed ID: 21725012