Pseudomonas aeruginosa PAO1, PA5213 (gcvP1)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5213
Name
gcvP1
Replicon chromosome
Genomic location 5868181 - 5871057 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253900.1
GI 15600406
Affymetrix PA5213_gcvP1_at
Entrez 880606
GenBank AAG08598.1
INSDC AAG08598.1
NCBI Locus Tag PA5213
protein_id(GenBank) gb|AAG08598.1|AE004934_5|gnl|PseudoCAP|PA5213
TIGR NTL03PA05214
UniParc UPI00000C5F59
UniProtKB Acc Q9HTX7
UniProtKB ID GCSP2_PSEAE
UniRef100 UniRef100_Q9HTX7
UniRef50 UniRef50_Q9HTX7
UniRef90 UniRef90_Q9HTX7

Product

Feature Type CDS
Coding Frame 1
Product Name
glycine cleavage system protein P1
Product Name Confidence: Class 2
Synonyms glycine decarboxylase
Evidence for Translation
Charge (pH 7) -8.40
Kyte-Doolittle Hydrophobicity Value -0.098
Molecular Weight (kDa) 104.7
Isoelectric Point (pI) 6.48

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 474 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003093 (925 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5213
Search term: gcvP1

Human Homologs

Ensembl 110, assembly GRCh38.p14
glycine decarboxylase [Source:HGNC Symbol;Acc:HGNC:4313]
E-value: 6.8e-300
Percent Identity: 54.9

References

Cloning and nucleotide sequence of the gcv operon encoding the Escherichia coli glycine-cleavage system.
Okamura-Ikeda K, Ohmura Y, Fujiwara K, Motokawa Y
Eur J Biochem 1993 Sep 1;216(2):539-48
PubMed ID: 8375392