Pseudomonas aeruginosa PAO1, PA5241 (ppx)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5241
Name
ppx
Synonym: gppA
Replicon chromosome
Genomic location 5900879 - 5902399 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_253928.1
GI 15600434
Affymetrix PA5241_ppx_at
Entrez 877947
GenBank AAG08626.1
INSDC AAG08626.1
NCBI Locus Tag PA5241
protein_id(GenBank) gb|AAG08626.1|AE004936_9|gnl|PseudoCAP|PA5241
TIGR NTL03PA05242
UniParc UPI000013211D
UniProtKB Acc Q9ZN70
UniProtKB ID PPX_PSEAE
UniRef100 UniRef100_Q9ZN70
UniRef50 UniRef50_Q9ZN70
UniRef90 UniRef90_Q9ZN70

Product

Feature Type CDS
Coding Frame 1
Product Name
exopolyphosphatase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -2.76
Kyte-Doolittle Hydrophobicity Value -0.271
Molecular Weight (kDa) 56.4
Isoelectric Point (pI) 6.70

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 497 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004821 (537 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5241
Search term: ppx

Human Homologs

References

An exopolyphosphatase of Escherichia coli. The enzyme and its ppx gene in a polyphosphate operon.
Akiyama M, Crooke E, Kornberg A
J Biol Chem 1993 Jan 5;268(1):633-9
PubMed ID: 8380170
Exopolyphosphate phosphatase and guanosine pentaphosphate phosphatase belong to the sugar kinase/actin/hsp 70 superfamily.
Reizer J, Reizer A, Saier MH Jr, Bork P, Sander C
Trends Biochem Sci 1993 Jul;18(7):247-8
PubMed ID: 8212131
Cloning and characterization of polyphosphate kinase and exopolyphosphatase genes from Pseudomonas aeruginosa 8830.
Zago A, Chugani S, Chakrabarty AM
Appl Environ Microbiol 1999 May;65(5):2065-71
PubMed ID: 10224002