Pseudomonas aeruginosa PAO1, PA5242 (ppk)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5242
Name
ppk
Replicon chromosome
Genomic location 5902386 - 5904596 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253929.1
GI 15600435
Affymetrix PA5242_ppk_at
Entrez 879700
GenBank AAG08627.1
INSDC AAG08627.1
NCBI Locus Tag PA5242
protein_id(GenBank) gb|AAG08627.1|AE004936_10|gnl|PseudoCAP|PA5242
TIGR NTL03PA05243
UniParc UPI0000132090
UniProtKB Acc Q9S646
UniProtKB ID PPK_PSEAE
UniRef100 UniRef100_Q9S646
UniRef50 UniRef50_Q9S646
UniRef90 UniRef90_Q9S646

Product

Feature Type CDS
Coding Frame 1
Product Name
polyphosphate kinase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 4.43
Kyte-Doolittle Hydrophobicity Value -0.168
Molecular Weight (kDa) 83.2
Isoelectric Point (pI) 7.72

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 452 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004822 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5242
Search term: ppk

Human Homologs

References

Polyphosphate kinase as a nucleoside diphosphate kinase in Escherichia coli and Pseudomonas aeruginosa.
Kuroda A, Kornberg A
Proc Natl Acad Sci U S A 1997 Jan 21;94(2):439-42
PubMed ID: 9012801
The polyphosphate kinase gene of Pseudomonas aeruginosa.
Ishige K, Kameda A, Noguchi T, Shiba T
DNA Res 1998 Jun 30;5(3):157-62
PubMed ID: 9734809
Cloning and characterization of polyphosphate kinase and exopolyphosphatase genes from Pseudomonas aeruginosa 8830.
Zago A, Chugani S, Chakrabarty AM
Appl Environ Microbiol 1999 May;65(5):2065-71
PubMed ID: 10224002