Pseudomonas aeruginosa PAO1, PA5372 (betA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5372
Name
betA
Replicon chromosome
Genomic location 6047364 - 6049049 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_254059.1
GI 15600565
Affymetrix PA5372_betA_at
Entrez 881124
GenBank AAG08757.1
INSDC AAG08757.1
NCBI Locus Tag PA5372
protein_id(GenBank) gb|AAG08757.1|AE004949_4|gnl|PseudoCAP|PA5372
TIGR NTL03PA05373
UniParc UPI00000C5FC9
UniProtKB Acc Q9HTJ2
UniProtKB ID BETA_PSEAE
UniRef100 UniRef100_B7V5R3
UniRef50 UniRef50_Q8FKI9
UniRef90 UniRef90_B7V5R3

Product

Feature Type CDS
Coding Frame 1
Product Name
choline dehydrogenase
Product Name Confidence: Class 2
Synonyms betA protein
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -0.59
Kyte-Doolittle Hydrophobicity Value -0.414
Molecular Weight (kDa) 61.8
Isoelectric Point (pI) 6.92

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 215 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004937 (526 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5372
Search term: betA

Human Homologs

Ensembl 110, assembly GRCh38.p14
choline dehydrogenase [Source:HGNC Symbol;Acc:HGNC:24288]
E-value: 1.5e-142
Percent Identity: 49.7

References

Characterization of an Escherichia coli gene encoding betaine aldehyde dehydrogenase (BADH): structural similarity to mammalian ALDHs and a plant BADH.
Boyd LA, Adam L, Pelcher LE, McHughen A, Hirji R, Selvaraj G
Gene 1991 Jul 15;103(1):45-52
PubMed ID: 1879697