Pseudomonas aeruginosa PAO1, PA5553 (atpC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5553
Name
atpC
Synonym: papG
Synonym: uncC
Replicon chromosome
Genomic location 6247811 - 6248236 (- strand)

Cross-References

RefSeq NP_254240.1
GI 15600746
Affymetrix PA5553_atpC_at
DNASU PaCD00007314
Entrez 878082
GenBank AAG08938.1
INSDC AAG08938.1
NCBI Locus Tag PA5553
protein_id(GenBank) gb|AAG08938.1|AE004967_9|gnl|PseudoCAP|PA5553
TIGR NTL03PA05554
UniParc UPI000012650A
UniProtKB Acc Q9HT21
UniProtKB ID ATPE_PSEAE
UniRef100 UniRef100_A6VF31
UniRef50 UniRef50_P41171
UniRef90 UniRef90_A6VF31

Product

Feature Type CDS
Coding Frame 1
Product Name
ATP synthase epsilon chain
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Detected using LC-MS/MS (14.73 kDa, PMID:21751344)
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -4.32
Kyte-Doolittle Hydrophobicity Value 0.158
Molecular Weight (kDa) 14.7
Isoelectric Point (pI) 4.93

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Outer Membrane Vesicle Class 1
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 484 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG005084 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5553
Search term: atpC

Human Homologs

References

The atp operon: nucleotide sequence of the genes for the gamma, beta, and epsilon subunits of Escherichia coli ATP synthase.
Saraste M, Gay NJ, Eberle A, Runswick MJ, Walker JE
Nucleic Acids Res 1981 Oct 24;9(20):5287-96
PubMed ID: 6272217
Solution structure of the epsilon subunit of the F1-ATPase from Escherichia coli and interactions of this subunit with beta subunits in the complex.
Wilkens S, Capaldi RA
J Biol Chem 1998 Oct 9;273(41):26645-51
PubMed ID: 9756905
Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa.
Choi DS, Kim DK, Choi SJ, Lee J, Choi JP, Rho S, Park SH, Kim YK, Hwang D, Gho YS
Proteomics 2011 Aug;11(16):3424-9
PubMed ID: 21751344