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               PA0024               
Key to diagram


View in GBrowse: (?) 16 putative orthologs View metabolic pathways using PseudoCyc Acknowledgements for this annotation
Gene Information
Strain Pseudomonas aeruginosa PAO1 (Tax ID: 208964) Replicon Chromosome(5651 genes, 6264404 bp) [ RefSeq ]
Gene name hemF  Alternate Gene Names
Locus tag PA0024 (View 4 updates) GenBank Identifier (GI) 15595222 (Precomputed BLAST results at BLINK )
Genomic location 25736 - 26653 (+) Feature type CDS 
Transposon Mutant Available?Transposon mutant library help No transposon mutant available yet Pseudomonas Ortholog Group Explanation of Orthologous Groups
Product Information
Product Name coproporphyrinogen III oxidase, aerobic (Class 2  Explanation of Product Name Confidence)
Alternate Product Names
Subcellular localization
Cytoplasmic (Class 3Explanation of Localization Confidence)
Function Classification / Gene Ontology (GO)
PseudoCAP Function Class Biosynthesis of cofactors, prosthetic groups and carriers
GO Accession GO Term Evidence
Molecular Function
GO:0004049 anthranilate synthase activity IDA
Biological Process
GO:0051188 cofactor biosynthetic process ISS
GO:0015994 chlorophyll metabolic process ISS
Cellular Component
COG PredictionExplanation of COG predictions
Accession Description Category
COG0408 HemF, Coproporphyrinogen III oxidase [Coenzyme metabolism]. Coenzyme metabolism
Pathways
Pathways Explanation of Pathways Field
Name Database Xref
Porphyrin and chlorophyll metabolism PseudoCAP
biosynthesis of proto- and siroheme PseudoCyc HEMESYN2-PWY
Porphyrin and chlorophyll metabolism KEGG pae00860 Computationally Generated
Metabolic pathways KEGG pae01100 Computationally Generated
Reactions
EC Number 1.3.3.3
Homology
BLINK Precomputed BLAST results at BLINK
Homologs Explanation of Homologs Field 80% similar to S. typhimurium hemF gene product.
Most Similar Human Homolog
ENSP00000264193, Percent Identity: 44.37%, E-Value: 2e-68, Ensembl Release: 56.
Description: Coproporphyrinogen-III oxidase, mitochondrial Precursor
Structure Features
PFAM predictions Explanation of PFAM predictions
Accession Domain Start Stop E-value Release No.
PF01218 Coprogen_oxidas, Coproporphyrinogen III oxidase. 1 301 1e-164 23.0
 
Operons/Regulons
Type operon
Genes
GeneProduct
hemF coproporphyrinogen III oxidase, aerobic
aroE shikimate dehydrogenase
Evidence Computationally Predicted
PubMed 18988623
Cross-Reference DOOR-13109
Microarray Expression Data
NCBI GEO Link
Sequence data
Upstream 500 BP Region CCTCCGCCAGCACATGCAGTTCGCTGTAGGCGCCCAGGGGGCCGGTGGCGTAGGCGACGCGGTCGCCGACCTTGAAACGGGTCACTTCGCTGCCCACCGC CTCGACCTCGCCGGCACCTTCGCTACCCAGTCCCGAGGGTAAGCCGGGGGCCGGATAGAGGCCGCTGCGGTAGTAGGTGTCGATGAAGTTCAGGCCAATG GCGCGATTGCGCACGCGGACTTCCCGGGGGCCCGGCTCGGCGGGTTGGTAGTCGCGGTATTCGAGGACTTCGGGGCCGCCGTAGGCAGCGAACTGGATGC GCTTGGCCATGCTGGAACTCCTGCTTCGTCAGGGTTTCGGACGGTCGCGCCGGGTGGGCGACCCTGGGTAAAGGCCTTCATCCAAGCCTTCCCCTTGACG GCCGTCAAGCGCCGGCTACCCATCCAGGGTGGTATGCTTGCGCCCTCGTTTCGTCGCCAGCCCGCGCCCCGCGCGGCCTCCCCGCTCCAAGGTGAACTCC

BLAST search against this genome or other genomes in database
Need more than 500 BP? Try our sequence retrieval tool or view intergenic regions in GBrowse.

DNA Sequence GTGACCGACCGTATCGCCGCTGTCAAAACCTACCTGCTCGACCTGCAAGACCGCATCTGCGCCGCCCTCGAGGCGGAGGACGGCAAGGCCCGCTTCGCCG AGGACGCCTGGGAGCGTCCGGCCGGTGGCGGCGGACGGACGCGGGTAATCGGCGACGGCGCATTGATCGAGAAGGGCGGGGTGAATTTTTCCCACGTCTT CGGCGATAGCCTGCCGCCCTCGGCCAGCGCCCATCGGCCGGAACTGGCCGGGCGCGGTTTCCAGGCGCTCGGCGTGTCGCTGGTGATCCATCCGGAAAAC CCCCACGTGCCGACGTCCCATGCCAACGTGCGTTTCTTCTGCGCCGAGAAGGAAGGCGAGGAGCCGGTCTGGTGGTTCGGCGGCGGCTTCGATCTGACCC CCTACTACGCCCACGAGGAAGACTGCGTGCATTGGCACCGGGTCGCTCGCGACGCCTGCGCGCCGTTCGGCGCGGACGTCTACCCGCGCTACAAGGAATG GTGCGACCGCTACTTCCACCTCAAGCACCGCAACGAGCCGCGCGGCATCGGCGGCCTGTTCTTCGACGACCTCAACCAGTGGGACTTCGACACCTGCTTC GCCTTCATCCGCGCCATCGGCGATGCCTATATCGACGCCTACCTGCCGATCGTCCAGCGCCGCAAGCACACGCCGTTCGATGAACGGCAGCGAGAGTTCC AGGCCTATCGTCGCGGTCGCTATGTGGAGTTCAACCTGGTCTTCGATCGTGGCACCCTGTTCGGCCTGCAGTCCGGCGGCCGTACCGAATCGATCCTGAT GTCGTTGCCGCCGCAGGTGCGCTGGGGCTATGACTGGAAACCCGAGCCGGGCAGCGAGGAAGCGCGCCTGACCGAGTATTTCCTCGCCGACCGCGATTGG CTCGCCGGCCAGCCCTGA

BLAST search against this genome or other genomes in database


Downstream 500 BP region Click here to view the nucleotide sequence of the region 500 BP downstream of this gene.

Protein Sequence MTDRIAAVKTYLLDLQDRICAALEAEDGKARFAEDAWERPAGGGGRTRVIGDGALIEKGGVNFSHVFGDSLPPSASAHRPELAGRGFQALGVSLVIHPEN PHVPTSHANVRFFCAEKEGEEPVWWFGGGFDLTPYYAHEEDCVHWHRVARDACAPFGADVYPRYKEWCDRYFHLKHRNEPRGIGGLFFDDLNQWDFDTCF AFIRAIGDAYIDAYLPIVQRRKHTPFDERQREFQAYRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSLPPQVRWGYDWKPEPGSEEARLTEYFLADRDW LAGQP

BLAST search against this genome or other genomes in database
View precomputed BLAST results against all genomes at NCBI BLINK
References
PubMed An oxygen-dependent coproporphyrinogen oxidase encoded by the hemF gene of Salmonella typhimurium.
Xu K, Elliott T.
J Bacteriol. 1993 Aug;175(16):4990-9.
PMID: 8349542
 
Alternate Annotations and Cross-References
TIGR NTL03PA00025
Systomonas PA0024
RefSeq NP_248714.1
GI 15595222
KEGG PA0024
GBrowse Click here for a GBrowse View of this and other annotations.
PseudoCyc Click here to view metabolic pathways in PseudoCyc.


We thank Cystic Fibrosis Foundation Therapeutics, Inc. for critical funding support for the Pseudomonas Genome Database. When acknowledging use of the database, please cite the article by Winsor et al. (2009; PMID:18978025) and not the web site URL. Thank you!

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