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               PA0401               
Key to diagram


View in GBrowse: 16 putative orthologs View metabolic pathways using PseudoCyc Acknowledgements for this annotation
Gene Information
Strain Pseudomonas aeruginosa PAO1 (Tax ID: 208964) Replicon Chromosome(5651 genes, 6264404 bp) [ RefSeq ]
Gene name   Alternate Gene Names pyrC', pyrX
Locus tag PA0401 (View 5 updates) Submit an Update GenBank Identifier (GI) 15595598 (Precomputed BLAST results at BLINK )
Genomic location 444690 - 443419 (-) Feature type CDS 
Transposon Mutant Available?Transposon mutant library help Yes (View in GBrowse) Pseudomonas Ortholog Group Explanation of Orthologous Groups
Product Information
Product Name noncatalytic dihydroorotase-like protein (Class 2  Explanation of Product Name Confidence)
Alternate Product Names
Subcellular localization
Cytoplasmic (Class 3Explanation of Localization Confidence)
Alternate Annotations and Cross-References
TIGR NTL03PA00402
Systomonas PA0401
RefSeq NP_249092.1
GI 15595598
KEGG PA0401
GBrowse Click here for a GBrowse View of this and other annotations.
PseudoCyc Click here to view metabolic pathways in PseudoCyc.
Operons/Regulons
Type operon
Genes
GeneProduct
PA0401 noncatalytic dihydroorotase-like protein
pyrB aspartate carbamoyltransferase
pyrR transcriptional regulator PyrR
Evidence Computationally Predicted
PubMed 18988623
Cross-Reference DOOR-13186
Genomic Context
Genomic context Explanation of Genomic Context Field - Downstream of pyrB and pyrR
Function Classification / Gene Ontology (GO)
PseudoCAP Function Class Nucleotide biosynthesis and metabolism
GO Accession GO Term Evidence
Molecular Function
GO:0004151 dihydroorotase activity IEA
Biological Process
GO:0009117 nucleotide metabolic process ISS
GO:0009220 pyrimidine ribonucleotide biosynthetic process IEA
Cellular Component
COG PredictionExplanation of COG predictions
Accession Description Category
COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]. Nucleotide transport and metabolism
Pathways
Pathways Explanation of Pathways Field
Name Database Xref
Pyrimidine metabolism KEGG pae00240 Computationally Generated
Metabolic pathways KEGG pae01100 Computationally Generated
Homology
BLINK Precomputed BLAST results at BLINK
Homologs Explanation of Homologs Field 100% identical to dihydroorotase-like protein [Pseudomonas aeruginosa]
86% similar to aspartate carbamoyltransferase 44k noncatalytic chaindihydro-orotase [Pseudomonas putida]
Most Similar Human Homolog
ENSP00000384510, Percent Identity: 31.63%, E-Value: 3e-29, Ensembl Release: 56.
Description: CAD protein
Structure Features
Structure Features Explanation of Structure Features Field PF00744/PS00482:Dihydroorotase signature 1
PFAM predictions Explanation of PFAM predictions  
Microarray Expression Data
NCBI GEO Link
Upstream 500 BP Region TTCGAGCAGCTATCGGTGGCGATCGTCGGCGATATCCTGCATTCGCGAGTAGCCCGTTCGAACATGCTGGCGCTCAAGACCCTGGGTTGCCCGGACATCC GCGTGATCGCCCCGCGCACCCTCTTGCCGATCGGCCTGGAAGAGCAGTACGGCGTGCGCGTGTTCACCAACGCCGACGAAGGCCTGAAGGACGTCGACGT GGTGATCATGCTGCGCCTGCAACGCGAGCGCATGCAGGGTGGCCTGCTACCCAGCGAGGGCGAGTTCTTCAAGCTCTACGGCCTGACCGAGAAGCGCCTG AAGCTGGCCAAGCCGGATGCCATCGTCATGCACCCTGGCCCGATCAACCGTGGCGTGGAGATCGAGTCGGCGGTGGCCGACGGGGCCCAGTCGGTGATCC TCAACCAGGTCACCTACGGCATCGCCATCCGCATGGCGGTGCTGTCCATGGCCATGAGCGGCCAGAACACCCAACGCCAGCTGGAACAGGAGGACGCCGA

BLAST search against this genome or other genomes in database
Need more than 500 BP? Try our sequence retrieval tool or view intergenic regions in GBrowse.

DNA Sequence ATGACCATCAGTATCCGAGGCGCCCGCGTCATCGACCCGGCCAGTGACCTGGACCAGGTCGGCGACCTCCACATCGAGGCTGGCAAGATCGTCGCCATCG GCGCCGCGCCGGCCGGCTTCAGCGCCCAGAAGACCCTCGACGGCGCCGGCCTGGTGGCCGCGCCGGGACTGGTCGATCTGAGCGTCGCCCTGCGCGAGCC GGGCTATGGACGCAAGGGCAACGTCGAAAGCGAGACCCGCGCCGCCGCGGCCGGCGGCACCACCAGCCTGTGCTGCCCGCCCTACACCCGGCCGGTGCTG GACACCCCGGCGGTGGCCGAGCTGATCCTCGACCGCGCCCGCGAGGCCGGCAACGCCAAGGTCTACCCCATCGGCGCGCTGACCCGCGGCTTCGGCGGCG AGCAACTGTCGGAACTGGTGGCCCTGCGCGACACCGGTTGCGTGGCCTTCACCAATGGCCTGCATGGCTTCGCCAGCAACCGCATCCTGCGGCGCGCCCT GGAGTACGCGGCGACCTTCGACCTGACGGTGATCTTCACCTCGCAGGACACCGATCTCGCCGAAGGCGGCCTCGCCCACGAAGGCCCGACCGCCAGCTTC CTCGGCCTCGCGGGGATCCCGGAGACCGCCGAGACCGTGGCCCTGGCCCGCAACCTGCTGCTGGTGGAACAGAGCGGCGTGCGCGCGCACTTCAGCCAGT TGACCAGCGCCCGCGGCATCGAACTCGTCGCCCAGGCCCAGGCCCGTGGCCTGCCGGTGACCTGCGACGTGGCGCTGTACCAGTTGATCCTCACCGACGA AGCGCTGGTGGGCTTCTCCAGCCTCTACCACGTGCAACCGCCGCTGCGCACCAGGGCCGACCGCGAAGCCCTGCGCGAGGCGGTGAAGAACGGCGTGGTA CAAGCCATCGCCAGCCACCACCAACCCCACGAGGCGGACGCCAAGAACGCGCCGTTCGCCGCCACCGAGCCGGGCATCAGCGGCGCCGAGCTGCTGCTGC CGCTGGCGATGACGCTGGTGCAGGACGGCCTGCTCGACCTGCCGACCCTGCTCGCCCGCCTCTCCCACGGCCCGGCCCAGGCACTACGCCTGCCTGCCGG GCGCCTGGCGGTGGGCCAGGCCGCCGACCTGGTGCTGTTCGACCCGCAGGGTTCGACCCTGGCCGGTGAGAGCTGGTACTCGAAGGGGCAGAACAGCCCG TTCGTCGGTCACTGCCTGCCGGGACGAGTGCGCTACACCCTGGTGGACGGACACCTGACCCACGAGGGCTGA

BLAST search against this genome or other genomes in database

Downstream 500 BP region Click here to view the nucleotide sequence of the region 500 BP downstream of this gene.
Protein Sequence MTISIRGARVIDPASDLDQVGDLHIEAGKIVAIGAAPAGFSAQKTLDGAGLVAAPGLVDLSVALREPGYGRKGNVESETRAAAAGGTTSLCCPPYTRPVL DTPAVAELILDRAREAGNAKVYPIGALTRGFGGEQLSELVALRDTGCVAFTNGLHGFASNRILRRALEYAATFDLTVIFTSQDTDLAEGGLAHEGPTASF LGLAGIPETAETVALARNLLLVEQSGVRAHFSQLTSARGIELVAQAQARGLPVTCDVALYQLILTDEALVGFSSLYHVQPPLRTRADREALREAVKNGVV QAIASHHQPHEADAKNAPFAATEPGISGAELLLPLAMTLVQDGLLDLPTLLARLSHGPAQALRLPAGRLAVGQAADLVLFDPQGSTLAGESWYSKGQNSP FVGHCLPGRVRYTLVDGHLTHEG

BLAST search against this genome or other genomes in database
View precomputed BLAST results against all genomes at NCBI BLINK
SNPs NOTE: This feature is currently open to beta-testing. We welcome feedback on how to improve this new resource. Please send any comments to pseudocap-mail@sfu.ca.

Showing SNPs occurring in PA0401 gene of Pseudomonas aeruginosa PAO1, Chromosome (443419 to 444690 bp)


Displaying the first five SNPs out of a total of 75 found in all isolate strains ( View all 75 )
Strain Type Mutation Description Effect Details GBrowse
DNA Protein
Pseudomonas aeruginosa 2192 Transition g.443422G>A
Silent
GGC(Gly) -> GGT(Gly) 		SNP-40215 View
Pseudomonas aeruginosa PA7 Transition g.443422G>A
Silent
GGC(Gly) -> GGT(Gly) 		SNP-484417 View
Pseudomonas aeruginosa PA14 Transition g.443458G>A
Silent
CGC(Arg) -> CGT(Arg) 		SNP-184558 View
Pseudomonas aeruginosa PA7 Transition g.443464T>C
Silent
CGA(Arg) -> CGG(Arg) 		SNP-484418 View
Pseudomonas aeruginosa PA7 Transition g.443467T>C
Silent
GGA(Gly) -> GGG(Gly) 		SNP-484419 View
Select to view SNPs in a specific strain
SNP Map
PubMed Aspartate transcarbamoylase genes of Pseudomonas putida: requirement for an inactive dihydroorotase for assembly into the dodecameric holoenzyme.
Schurr MJ, Vickrey JF, Kumar AP, Campbell AL, Cunin R, Benjamin RC, Shanley MS, O'Donovan GA.
J Bacteriol. 1995 Apr;177(7):1751-9.
PMID: 7896697
 


We thank Cystic Fibrosis Foundation Therapeutics, Inc. for critical funding support for the Pseudomonas Genome Database. When acknowledging use of the database, please cite the article by Winsor et al. (2009; PMID:18978025) and not the web site URL. Thank you!

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