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               PA0651               
Key to diagram


View in GBrowse: 16 putative orthologs View metabolic pathways using PseudoCyc Acknowledgements for this annotation
Gene Information
Strain Pseudomonas aeruginosa PAO1 (Tax ID: 208964) Replicon Chromosome(5651 genes, 6264404 bp) [ RefSeq ]
Gene name trpC  Alternate Gene Names
Locus tag PA0651 (View 4 updates) Submit an Update GenBank Identifier (GI) 15595848 (Precomputed BLAST results at BLINK )
Genomic location 705130 - 705966 (+) Feature type CDS 
Transposon Mutant Available?Transposon mutant library help Yes (View in GBrowse) Pseudomonas Ortholog Group Explanation of Orthologous Groups
Product Information
Product Name indole-3-glycerol-phosphate synthase (Class 1  Explanation of Product Name Confidence)
Alternate Product Names
Subcellular localization
Cytoplasmic (Class 3Explanation of Localization Confidence)
Alternate Annotations and Cross-References
TIGR NTL03PA00652
Systomonas PA0651
RefSeq NP_249342.1
GI 15595848
KEGG PA0651
GBrowse Click here for a GBrowse View of this and other annotations.
PseudoCyc Click here to view metabolic pathways in PseudoCyc.
Operons/Regulons
Type operon
Genes
GeneProduct
trpG anthranilate synthase component II
trpD anthranilate phosphoribosyltransferase
trpC indole-3-glycerol-phosphate synthase
Evidence Computationally Predicted
PubMed 18988623
Cross-Reference DOOR-13249
Function Classification / Gene Ontology (GO)
PseudoCAP Function Class Amino acid biosynthesis and metabolism
GO Accession GO Term Evidence
Molecular Function
GO:0004635 phosphoribosyl-AMP cyclohydrolase activity ISS
GO:0004425 indole-3-glycerol-phosphate synthase activity RCA
Biological Process
GO:0006520 amino acid metabolic process IDA
GO:0000162 tryptophan biosynthetic process RCA
Cellular Component
COG PredictionExplanation of COG predictions
Accession Description Category
COG0134 TrpC, Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]. Amino acid transport and metabolism
Pathways
Pathways Explanation of Pathways Field
Name Database Xref
Phenylalanine, tyrosine and tryptophan biosynthesis PseudoCAP
phenylalanine, tyrosine and tryptophan biosynthesis, complete PseudoCyc COMPLETE-ARO-PWY
tryptophan biosynthesis PseudoCyc TRPSYN-PWY
pathways of chorismate PseudoCyc ALL-CHORISMATE-PWY
Phenylalanine, tyrosine and tryptophan biosynthesis KEGG pae00400 Computationally Generated
Metabolic pathways KEGG pae01100 Computationally Generated
Two-component system KEGG pae02020 Computationally Generated
Reactions
EC Number 4.1.1.48
Homology
BLINK Precomputed BLAST results at BLINK
Structure Features
Structure Features Explanation of Structure Features Field PS00614: Indole-3-glycerol phosphate synthase signature
PFAM predictions Explanation of PFAM predictions
Accession Domain Start Stop E-value Release No.
PF00218 IGPS, Indole-3-glycerol phosphate synthase. 37 263 3e-89 23.0
 
Microarray Expression Data
NCBI GEO Link
Upstream 500 BP Region CTGACCAACCCGGCGGGAGTCAGGCACCAGGTGGTCGGGGTGTTCACCCAGGAACTGTGCAAGCCGCTGGCTGAAGTGCTCAAGCGTCTCGGCAGCGAGC ATGTGCTGGTGGTGCATTCGCGCGACGGGCTGGACGAGTTCAGTCTGGCCGCGGCGACCCACATTGCCGAGTTGAAGGACGGCGAGGTACGCGAGTACGA AGTGCGTCCCGAGGACTTCGGGATCAAGAGCCAGACCCTGATGGGGCTGGAGGTCGACAGTCCGCAGGCCTCGCTGGAACTGATCCGCGACGCTTTGGGG CGGCGCAAGACCGAGGCTGGGCAGAAGGCCGCCGAGCTGATCGTGATGAATGCCGGCCCGGCACTGTACGCTGCCGATCTGGCGACCAGCCTGCACGAGG GCATTCAACTGGCCCACGATGCCCTGCACACCGGGCTGGCACGGGAGAAGATGGACGAACTGGTGGCCTTCACCGCCGTTTACAGAGAGGAGAACGCACA

BLAST search against this genome or other genomes in database
Need more than 500 BP? Try our sequence retrieval tool or view intergenic regions in GBrowse.

DNA Sequence GTGAGTGTGCCGACGGTTCTGCAGAAGATCCTCGCCCGCAAGGCCGAGGAGGTCGCCGAGCGCCGTGCGCGCGTCAACCTGGCAGAGGTCGAGCGGCTGG CGCGTAGCGCCGATGCGCCGCGCGGCTTCGCCAATGCCCTGCTGGAGCGGGCCAAGCGCAAGGAGCCGGCAGTGATCGCCGAGATCAAGAAGGCATCGCC GAGCAAGGGCGTGCTGCGCGAACACTTCGTCCCGGCGGAGATCGCCCGCAGCTACGAGGCGGGTGGCGCGGCGTGCCTGTCGGTGCTCACCGACGTGGAC TTCTTCCAGGGCGCCGATGCCTATCTGAAGGAAGCGCGGGCCGCCTGTGCGCTGCCGGTGATCCGCAAGGACTTCATGATCGATCCGTACCAGATCGTCG AGGCGCGGGCGATCGGTGCCGACTGCATCCTGCTGATCGTCTCGGCGCTGGACGACGTGCTGATGGCCGAACTGGCGGCGACTGCCAAGTCGGTCGGTCT CGACGTACTGGTCGAAGTGCATGACGGCACCGAGCTGGAACGTGCACTGAAGACCCTGGACACGCCGTTGGTGGGCATCAACAACCGCAACCTGCACACC TTCGAGGTGAGCCTGGAAACCACCCTCGACCTGTTGCCGGAAATTCCCCGCGACCGCCTGGTGGTCACCGAGAGCGGTATTCTCAACCGGGCCGACGTGG AGCTGATGGAAGTCAGCGAGGTCTACGCCTTCCTGGTTGGCGAGGCGTTCATGCGGGCCGACGATCCTGGCCTCGAGCTGAAGCGCCTGTTCTTCCAGGA GCGTGGTGCTGTGGTGCTGGGCGCCGATCCTGACTGA

BLAST search against this genome or other genomes in database

Downstream 500 BP region Click here to view the nucleotide sequence of the region 500 BP downstream of this gene.
Protein Sequence MSVPTVLQKILARKAEEVAERRARVNLAEVERLARSADAPRGFANALLERAKRKEPAVIAEIKKASPSKGVLREHFVPAEIARSYEAGGAACLSVLTDVD FFQGADAYLKEARAACALPVIRKDFMIDPYQIVEARAIGADCILLIVSALDDVLMAELAATAKSVGLDVLVEVHDGTELERALKTLDTPLVGINNRNLHT FEVSLETTLDLLPEIPRDRLVVTESGILNRADVELMEVSEVYAFLVGEAFMRADDPGLELKRLFFQERGAVVLGADPD

BLAST search against this genome or other genomes in database
View precomputed BLAST results against all genomes at NCBI BLINK
SNPs NOTE: This feature is currently open to beta-testing. We welcome feedback on how to improve this new resource. Please send any comments to pseudocap-mail@sfu.ca.

Showing SNPs occurring in PA0651 gene of Pseudomonas aeruginosa PAO1, Chromosome (705130 to 705966 bp)


Displaying the first five SNPs out of a total of 97 found in all isolate strains ( View all 97 )
Strain Type Mutation Description Effect Details GBrowse
DNA Protein
Pseudomonas aeruginosa PA7 Transition g.705162C>T
Silent
CTC(Leu) -> CTT(Leu) 		SNP-442196 View
Pseudomonas aeruginosa PA7 Transition g.705180G>A
Silent
GAG(Glu) -> GAA(Glu) 		SNP-442197 View
Pseudomonas aeruginosa PA14 Transversion g.705195T>A
Silent
CGT(Arg) -> CGA(Arg) 		SNP-145104 View
Pseudomonas aeruginosa PA7 Transition g.705195T>C
Silent
CGT(Arg) -> CGC(Arg) 		SNP-442198 View
Pseudomonas aeruginosa PA7 Transition g.705207C>T
Silent
AAC(Asn) -> AAT(Asn) 		SNP-442199 View
Select to view SNPs in a specific strain
SNP Map
PubMed DNA sequences and characterization of four early genes of the tryptophan pathway in Pseudomonas aeruginosa.
Essar DW, Eberly L, Han CY, Crawford IP.
J Bacteriol. 1990 Feb;172(2):853-66.
PMID: 2105306
 


We thank Cystic Fibrosis Foundation Therapeutics, Inc. for critical funding support for the Pseudomonas Genome Database. When acknowledging use of the database, please cite the article by Winsor et al. (2009; PMID:18978025) and not the web site URL. Thank you!

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