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               PA0669               
Key to diagram


View in GBrowse: 16 putative orthologs View metabolic pathways using PseudoCyc Acknowledgements for this annotation
Gene Information
Strain Pseudomonas aeruginosa PAO1 (Tax ID: 208964) Replicon Chromosome(5651 genes, 6264404 bp) [ RefSeq ]
Gene name   Alternate Gene Names
Locus tag PA0669 (View 5 updates) Submit an Update GenBank Identifier (GI) 161486764 (Precomputed BLAST results at BLINK )
Genomic location 730703 - 727608 (-) Feature type CDS 
Transposon Mutant Available?Transposon mutant library help Yes (View in GBrowse) Pseudomonas Ortholog Group Explanation of Orthologous Groups
Product Information
Product Name probable DNA polymerase alpha chain (Class 3  Explanation of Product Name Confidence)
Alternate Product Names
Subcellular localization
Cytoplasmic (Class 2Explanation of Localization Confidence)
Cytoplasmic (Class 3Explanation of Localization Confidence)
Alternate Annotations and Cross-References
TIGR NTL03PA00670
Systomonas PA0669
RefSeq NP_249360.2
GI 161486764
KEGG PA0669
GBrowse Click here for a GBrowse View of this and other annotations.
PseudoCyc Click here to view metabolic pathways in PseudoCyc.
Function Classification / Gene Ontology (GO)
PseudoCAP Function Class Putative enzymes
DNA replication, recombination, modification and repair
GO Accession GO Term Evidence
Molecular Function
GO:0003887 DNA-directed DNA polymerase activity IEA
Biological Process
GO:0006260 DNA replication IEA
Cellular Component
GO:0009360 DNA polymerase III complex IEA
COG PredictionExplanation of COG predictions
Accession Description Category
COG0587 DnaE, DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]. DNA replication, recombination, and repair
Pathways
Pathways Explanation of Pathways Field
Name Database Xref
Purine metabolism KEGG pae00230 Computationally Generated
Pyrimidine metabolism KEGG pae00240 Computationally Generated
Metabolic pathways KEGG pae01100 Computationally Generated
DNA replication KEGG pae03030 Computationally Generated
Mismatch repair KEGG pae03430 Computationally Generated
Homologous recombination KEGG pae03440 Computationally Generated
Homology
BLINK Precomputed BLAST results at BLINK
Homologs Explanation of Homologs Field 47% similar to DnaE gene product [E. coli]
Structure Features
Structure Features Explanation of Structure Features Field PD02001: DNA POLYMERASE III ALPHA signature
PFAM predictions Explanation of PFAM predictions
Accession Domain Start Stop E-value Release No.
PF02811 PHP, PHP domain. 12 188 6e-11 23.0
PF07733 DNA_pol3_alpha, Bacterial DNA polymerase III alpha subunit. 223 699 1e-179 23.0
PF01336 tRNA_anti, OB-fold nucleic acid binding domain. 941 1016 2e-06 23.0
 
Microarray Expression Data
NCBI GEO Link
Upstream 500 BP Region AGCGCCGAACGCGAGGCGGCCATGCTCTTCGAACTGACCCGCGGCCGTCTCGAACAGCTGCAACTGCCCGCCCCCGTGCATGCCGTGCGCCTGGAGGCCC GCGAGCTGCCCCCCTTCACGCCGCAGCACCGCGAACTGTTCGACGAGCGCCCACAGCAGTATCTCGGCTGGGAACAGTTGCGGGAACGCCTGCGCGCGCG GCTGGGCGACGAGGCGGTACAGGGCCTGAGCGCCGTCGCCGAACACCGTCCGGAGCGAAGCTGGCGGCCGCACAGCTGCGACAGGGCGCAATCGCCGGCA GCCTGCGGCCTCCGACCCGGCTGGCTGCTGGCGGAGCCACGCCCCCTCGGCGAGGCCTTGCCCACCGTGCTGGCCGGCCCGGAGCGGATCGAGTCGGGCT GGTGGGATGGCGAAGACATCCGCCGCGACTATTACCTGGTGGAAACCCGCAGCGGACAACGTGCCTGGGTCTATCGCGAGGTCGGTAGCGAGGGGCCGCT

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Need more than 500 BP? Try our sequence retrieval tool or view intergenic regions in GBrowse.

DNA Sequence GTGGCTGCATGGCTGGTTCGCATGAGCGCCTACGCCGAACTGCATTGCCTGTCCAACTTCAGCTTCCAGCGCGGCGCCTCCAGCGCCACGGAACTCTTCG CCCGTGCAGCGCGCCTGGGCTATCGGGCCCTGGCGATCACCGACGAATGCAGCCTGGCCGGTATCGTACGGGCCTGGCAGGCGGCGCGGGAGCACCAGGT ACAACTGATCGTCGGCAGCGAAATCCGCCTCGAACAGGGGCCCAAGCTGGTCCTCCTGGCGGAGGACCTGGAGGGCTACCAGAACCTCTGTCGCCTCATC ACCCGCGGCCGGCGACAAGCCGACAAGGGCCACTACCGGCTGCTGCGCGAAGATCTGCAACAGCCGCTCGCCGGCCTGTTGGCGATCTGGTTGCCGAACG ACCATGGGGACGAGCAGGCTGCTTGGCTCCGCGAACGCTTCCCCCAGCGCCTTTGGCTGGGCGTCGAGTTGCATCGCGGCGCCGATGACGATGCCCGCCT GGACAAACTGCTCGCGCTCGCCTCGCATCTCCGGCTACCGCCCGTGGCCTGCGGCGACGTCCACATGCACGCCCGCGGCAGGCGAGCCCTGCAGGACTGC ATGACAGCGATCCGCAACCATCTGCCGGTCAGCGAGGCCGGCGCCTATCTCTTCCCCAACGGGGAACGCCACCTGCGTACCCTGGAGGCCCTGCAGGGGA TCTACCCGCAAGCCCTGCTGGCGGAAACCCTGAAGATCGCCGAACGCTGCCGGTTCGATCTGGAACAGCTGAAATACCAGTACCCACGCGAATTGGTACC GGCCGGACACGACCCGGCGTCATGGCTCCGCCATCTCACCGAACAGGGCATCGCCAGGCGCTGGCCGAACGGCGCGAGCGCCAAGGTCCGCAAGCAGATC GAGAGAGAACTCGAGCTGATCGCCGAACTGGGCTATGAAAGCTATTTCCTCACCGTGCAGGACATCGTCGCCTTCGCCCGGGGCCGGAAAATCCTTTGCC AGGGCCGCGGCTCGGCGGCCAACTCGGCAGTGTGCTTCGCCCTCGGCATCACCGAGTTGGACCCGGACCGGACCAACCTGCTGTTCGAGCGCTTCCTTTC CCGCGAGCGCAACGAACCACCGGACATCGACGTGGATTTCGAACACGAGCGTCGCGAGGAGGTCATCCAGTACGTTTTCACACGCTACGGACGCCAGCGC GCGGCGCTGACCGCGGTGGTCAGCACCTACCACGGCGCCGGCGCGGTGCGCGACGTAGCCAAGGCCCTGGGTCTGCCGCCCGAGCAGGTCGACGTCCTGG CCAACTGCTGCGGCCGCTGGAGCGACCAGGCCCCCAGCGCCGAACGCCTGGAAGAGGCCGGCTTCGATCCGCAGAGTCCGATCCTGCGCCGGGTGCTGGC CCTGACCGACGAGTTGATCGGTTTTCCGCGCCACCTCTCGCAGCACCCCGGCGGCTTCGTCATCTCCGAGCAGCCATTGGACACCCTGGTCCCGGTGGAG AATGCCAGCATGGCCGAACGCACGGTGATCCAGTGGGACAAGGACGATCTCGACGCGGTCGGCCTGCTCAAGGTCGACGTCCTCGCCCTGGGCATGCTCA GCGCCCTGCGCCGCAGCTTCGACCTGATCCACGCGCTGCGCGGCGGCAAGCGGTTGAGCATCGCCAGTATCCCGAGCGAAGACCCGGCTACCTACGAAAT GATCAGCCGCGCCGATACCATCGGCGTGTTCCAGATCGAGTCGCGCGCCCAGATGGCCATGCTGCCACGCCTGCGCCCGCAGAAGTTCTACGACCTGGTG ATCCAGGTCGCCATCGTCCGCCCAGGGCCGATCCAGGGCGACATGGTGCATCCTTACCTGCGCCGGCGAAACGGAGAAGAGCCGGTGGCCTATCCGTCAG CCGAACTGGAGGAAGTCTTCGAACGAACCCTGGGCGTCCCGTTGTTCCAGGAACAGGTCATGGAACTGGCGATCGTCGCCGCCGACTACACGCCGGGCGA GGCGGACGAACTGCGTCGCTCGATGGCCGCCTGGAAGCGTCATGGCGGCCTGGAACACCACCGCGAGCGGCTGACCCGAGGCATGCTCGCCAAGGGCTAC GAGGCCGACTTCGCAGCGCGCATCTTCGAGCAGATCAAAGGCTTCGGCAGCTACGGTTTCCCTGAATCCCACGCCGCCAGCTTCGCCCTGCTCACCTACG CCAGCAGTTGGTTGAAACGTCACGAGCCGGCGGCCTTCGCCTGCGCCTTGATCAACAGTTGGCCGATGGGCTTCTACAGCCCCGACCAGTTGCTCCAGGA CGCCCGCCGTCACGCCCTGCAGACACGCCCGGTGGATGTCCGCCACAGCGGTTGGGATTGCAGCCTGGAGTCGTTTGGCCAGGCGCAACCGGCCATACGC CTTGGCCTGCGGATGATCCGAGGCTTTCGCGAGGAGGATGCCAGGCGTATCGAGCAGGTCCGGGAGGCCGAGCCGTTCCTCGACGTGCACGATCTCGGCC GACGCGCCAGGCTCGACGCCCGGGCCCTGGAGTTGCTGGCCGATGCCGGCGCCCTGCGCGGTCTCGCCGGACACCGGCACAAGGCGCGCTGGGCCGTCGC CAGCGTCGAGCCGCAATTGCCGCTGTTCGCCGAAGGGACCGCCATCGAAGAGAGCACGGTCAGCCTGCCACTGCCTTCGCGCGGCGAGGAACTGCTGAGC GATTACGCTCTCCTCGGCACCACCCTCGGCCCGCATCCGCTGAAACTCTTGCGTGGACAGCTCAAGGCCCGCCGCTGCCGCGACTCCCGCGAACTGGCGA AACTGGGACATGGGCGACCGATACGGGTCGCCGGCCTGGTGGTCGGCCGGCAGCGCCCACAGACCGCCAGCGGCATCACCTTCATCACCCTGGAAGACGA GTTCGGCATGGTCAACGTGGTGGTCCGACACGACCTTGCCGAACGGCAGAGGCGGCCATTCCTCGAGTCCCGGCTGCTACAGGTGGAGGGCATCCTGGAG TCCTCCGGTGAGGTGCGCCACGTCATCGCCGGGCGCCTGCATGACCTGACCCCTCTACTCACCGGCCTGGACGTCCGCAGCCGGGATTTCCATTGA

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Downstream 500 BP region Click here to view the nucleotide sequence of the region 500 BP downstream of this gene.
Protein Sequence MAAWLVRMSAYAELHCLSNFSFQRGASSATELFARAARLGYRALAITDECSLAGIVRAWQAAREHQVQLIVGSEIRLEQGPKLVLLAEDLEGYQNLCRLI TRGRRQADKGHYRLLREDLQQPLAGLLAIWLPNDHGDEQAAWLRERFPQRLWLGVELHRGADDDARLDKLLALASHLRLPPVACGDVHMHARGRRALQDC MTAIRNHLPVSEAGAYLFPNGERHLRTLEALQGIYPQALLAETLKIAERCRFDLEQLKYQYPRELVPAGHDPASWLRHLTEQGIARRWPNGASAKVRKQI ERELELIAELGYESYFLTVQDIVAFARGRKILCQGRGSAANSAVCFALGITELDPDRTNLLFERFLSRERNEPPDIDVDFEHERREEVIQYVFTRYGRQR AALTAVVSTYHGAGAVRDVAKALGLPPEQVDVLANCCGRWSDQAPSAERLEEAGFDPQSPILRRVLALTDELIGFPRHLSQHPGGFVISEQPLDTLVPVE NASMAERTVIQWDKDDLDAVGLLKVDVLALGMLSALRRSFDLIHALRGGKRLSIASIPSEDPATYEMISRADTIGVFQIESRAQMAMLPRLRPQKFYDLV IQVAIVRPGPIQGDMVHPYLRRRNGEEPVAYPSAELEEVFERTLGVPLFQEQVMELAIVAADYTPGEADELRRSMAAWKRHGGLEHHRERLTRGMLAKGY EADFAARIFEQIKGFGSYGFPESHAASFALLTYASSWLKRHEPAAFACALINSWPMGFYSPDQLLQDARRHALQTRPVDVRHSGWDCSLESFGQAQPAIR LGLRMIRGFREEDARRIEQVREAEPFLDVHDLGRRARLDARALELLADAGALRGLAGHRHKARWAVASVEPQLPLFAEGTAIEESTVSLPLPSRGEELLS DYALLGTTLGPHPLKLLRGQLKARRCRDSRELAKLGHGRPIRVAGLVVGRQRPQTASGITFITLEDEFGMVNVVVRHDLAERQRRPFLESRLLQVEGILE SSGEVRHVIAGRLHDLTPLLTGLDVRSRDFH

BLAST search against this genome or other genomes in database
View precomputed BLAST results against all genomes at NCBI BLINK
SNPs NOTE: This feature is currently open to beta-testing. We welcome feedback on how to improve this new resource. Please send any comments to pseudocap-mail@sfu.ca.

Showing SNPs occurring in PA0669 gene of Pseudomonas aeruginosa PAO1, Chromosome (727608 to 730703 bp)


Displaying the first five SNPs out of a total of 513 found in all isolate strains ( View all 513 )
Strain Type Mutation Description Effect Details GBrowse
DNA Protein
Pseudomonas aeruginosa PA7 Transition g.727611A>G
Silent
CAT(His) -> CAC(His) 		SNP-340397 View
Pseudomonas aeruginosa PA7 Transition g.727614G>A
Silent
TTC(Phe) -> TTT(Phe) 		SNP-340398 View
Pseudomonas aeruginosa PA7 Transition g.727617A>G
Silent
GAT(Asp) -> GAC(Asp) 		SNP-340399 View
Pseudomonas aeruginosa PA7 Transversion g.727629G>T
Silent
GTC(Val) -> GTA(Val) 		SNP-340400 View
Pseudomonas aeruginosa PA7 Transversion g.727638G>T
Silent
GGC(Gly) -> GGA(Gly) 		SNP-340401 View
Select to view SNPs in a specific strain
SNP Map
Operons/Regulons
Type operon
Genes
GeneProduct
PA0669 probable DNA polymerase alpha chain
PA0670 hypothetical protein
PA0671 hypothetical protein
Evidence Computationally Predicted
PubMed 18988623
Cross-Reference DOOR-13256
Genomic Context
Genomic context Explanation of Genomic Context Field - Adjacent to an rRNA cluster.
PubMed  


We thank Cystic Fibrosis Foundation Therapeutics, Inc. for critical funding support for the Pseudomonas Genome Database. When acknowledging use of the database, please cite the article by Winsor et al. (2009; PMID:18978025) and not the web site URL. Thank you!

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