Pseudomonas Genome Database - Annotation for PA0746

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PA0746

Key to diagram

View in GBrowse:

4 putative orthologs

View metabolic pathways using PseudoCyc

Acknowledgements for this annotation

Overview
Functional Data
Sequence Data
Operons/Regulons
Polymorphisms
References

Gene Information
Strain	Pseudomonas aeruginosa PAO1 (Tax ID: 208964)	Replicon	Chromosome(5651 genes, 6264404 bp) [ RefSeq ]
Gene name		Alternate Gene Names
Locus tag	PA0746 (View 3 updates) Submit an Update	GenBank Identifier (GI)	15595943 (Precomputed BLAST results at BLINK )
Genomic location	814492 - 813329 (-)	Feature type	CDS
Transposon Mutant Available?	Yes (View in GBrowse)	Pseudomonas Ortholog Group	POG000720
Product Information
Product Name	probable acyl-CoA dehydrogenase (Class 3 )
Alternate Product Names
Subcellular localization	Cytoplasmic (Class 3)
Alternate Annotations and Cross-References
TIGR	NTL03PA00747
Systomonas	PA0746
RefSeq	NP_249437.1
GI	15595943
KEGG	PA0746
GBrowse	Click here for a GBrowse View of this and other annotations.
PseudoCyc	Click here to view metabolic pathways in PseudoCyc.

Operons/Regulons

Type

operon

Genes

Gene	Product
PA0746	probable acyl-CoA dehydrogenase
PA0747	probable aldehyde dehydrogenase

Evidence

Computationally Predicted

PubMed

18988623

Cross-Reference

DOOR-13270

Function Classification / Gene Ontology (GO)

PseudoCAP Function Class

Putative enzymes

Pathways

Name	Database	Xref
Geraniol degradation	KEGG	pae00281	Computationally Generated
1- and 2-Methylnaphthalene degradation	KEGG	pae00624	Computationally Generated

Homology

BLINK

Precomputed BLAST results at BLINK

Homologs

66% similar to putative dehydrogenase FadE9 [Mycobacterium tuberculosis]

Most Similar Human Homolog

ENSP00000281182, Percent Identity: 54.93%, E-Value: 3e-113, Ensembl Release: 56.
Description: Isobutyryl-CoA dehydrogenase, mitochondrial Precursor

Structure Features

BL00072: Acyl-CoA dehydrogenases signature 1

PFAM predictions

Accession	Domain	Start	Stop	E-value	Release No.
PF02771	Acyl-CoA_dh_N, Acyl-CoA dehydrogenase, N-terminal domain.	6	117	2e-33	23.0
PF02770	Acyl-CoA_dh_M, Acyl-CoA dehydrogenase, middle domain.	121	172	2e-17	23.0
PF00441	Acyl-CoA_dh_1, Acyl-CoA dehydrogenase, C-terminal domain.	227	377	2e-43	23.0
PF08028	Acyl-CoA_dh_2, Acyl-CoA dehydrogenase, C-terminal domain.	244	366	5e-14	23.0

Microarray Expression Data

NCBI GEO

Link

Upstream 500 BP Region

GCGGAAGGCGCCGAGTGCCTGCTCGACGGCTCGCAGTGCCAGGTCGAAGGCTATCCCAACGGCAACTGGCTCGGTCCCACCCTGTTCCGCGCAGTGACGC CGAAGATGGGCCTGTACCGCGAGGAAATCTTCGGCCCGGTGCTGGCCTGCCTGGAGGTGGAAAGCCTGGAAGAGGCCATCGCCCTGGTCAACGCCAACCC CTATGGCAATGGAACAAGCCTGTTCACCCGCTCCGGCGGCGCCGCTCGGCGCTACCAGCACGCGGTGCAGGTCGGCCAGGTGGGTATCAACGTGCCGATC CCGGTACCGCTGCCGTTCTTCTCCTTCACCGGCTGGAAGGGTTCCTTCTACGGCGACCTGCACGCCTACGGCAAGCAGGCGGTGCGCTTCTATACCGAGA CCAAGACCGTCACCAGCCGCTGGTTCGACGATGAACCGACGACCGACGAATCGTCGGCCGGCCCGAACATGACCATCCATCTCAAGTGACCCGAGGACCT

Need more than 500 BP? Try our sequence retrieval tool or view intergenic regions in GBrowse.

DNA Sequence

ATGGATTTCGACCTCACCGAAGAACAACGCCTGCTGGTGGAGAGCGCCCGCGCCTTCGCCCGCCACGAACTGGCGCCGAAGGCGGCCGACTGGGACCGCG ACCATCACTTCCCGGTGGAAGTCATCCGCGCCGCCGCCGAACAGGGCTACCTCGGCCTGTACATCGCCGAGGAAGACGGCGGCCTGGGCCTGTCGCGGCT GTCCACTTCGCTGATCTTCGAGCAACTGGCCGCCGGCTGCGTGGCCACTACCGCCTACATCAGCATCCACAACATGGCCGCCTGGATGCTCGCCTCGTTC GGCGACGCGGCGCTGAAGGAGGCCTGGCTGCCCGGCCTGATCGGCGGCGAGTCGCTCGCCTCCTATTGCCTGACCGAGCCCGATGCCGGCTCCGACGCCG CGCGCCTGCGCACCCGCGCCCGCCGCGAGGGCGACGAATACGTGCTGGACGGCAGCAAGTGCTTCATTTCCGGCGCCGGCAGCACCCAGGTGCTGATCGT CATGGCGCGCACCGGCGAGGACGGCGCCAGGGGCATCTCCTGCTTCCTGGTACCGGCCGACGCGCCCGGCATCCGCTACGGCCGCAACGAGGACAAGATG GGCTGGCGCGCGCAGCCGACCCGCACCATCACCTTCGAAGGCGTGCGCATCCCCGCCGGCAACCGCATCGGCCCGGAGGGCCAAGGCTTCGTCTATGCCA TGAAAGGCCTCGACGGCGGCCGCCTGAACATCGCCAGTTGTTCCCTGGGCGCCGCCCAGGCGGCGCTGGAGCAGTCGATGCGCTACGTCGAGGAGCGCGA GCAGTTCGGCAAGCCGCTGGCGACCTTCCAGGCCTTGCAGTTCAAGCTCGCCGACATGCTCACCGAACTCACCGCCAGCCGCCAGATGGTCCGCCTCGGC GCCCATCGGCTGGACCGCGGCGACGCCGAGGCGACCCTGTACTGCGCAATGGCCAAGCGCTTCGCCACCGACCGCTGCTTCGATGTCTGCAACGAGGCCT TGCAACTGCACGGCGGCTACGGCTATCTCAACGATTATCCGCTGGAGCGCTGGGTACGCGACACCCGCGTGCACCAGATCCTCGAAGGCACCAACGAAAT CATGCGGGTGATCGTCGCCCGCCGCCTGCTGGAGCAGGGCGGCATGCTCGATCGCCTGCTGTGA

Downstream 500 BP region

Click here to view the nucleotide sequence of the region 500 BP downstream of this gene.

Protein Sequence

MDFDLTEEQRLLVESARAFARHELAPKAADWDRDHHFPVEVIRAAAEQGYLGLYIAEEDGGLGLSRLSTSLIFEQLAAGCVATTAYISIHNMAAWMLASF GDAALKEAWLPGLIGGESLASYCLTEPDAGSDAARLRTRARREGDEYVLDGSKCFISGAGSTQVLIVMARTGEDGARGISCFLVPADAPGIRYGRNEDKM GWRAQPTRTITFEGVRIPAGNRIGPEGQGFVYAMKGLDGGRLNIASCSLGAAQAALEQSMRYVEEREQFGKPLATFQALQFKLADMLTELTASRQMVRLG AHRLDRGDAEATLYCAMAKRFATDRCFDVCNEALQLHGGYGYLNDYPLERWVRDTRVHQILEGTNEIMRVIVARRLLEQGGMLDRLL

BLAST search against this genome or other genomes in database
View precomputed BLAST results against all genomes at NCBI BLINK

SNPs

NOTE: This feature is currently open to beta-testing. We welcome feedback on how to improve this new resource. Please send any comments to pseudocap-mail@sfu.ca.

Showing SNPs occurring in PA0746 gene of Pseudomonas aeruginosa PAO1, Chromosome (813329 to 814492 bp)

Displaying the first five SNPs out of a total of 38 found in all isolate strains ( View all 38 )

Strain	Type	Mutation Description		Effect	Details	GBrowse
		DNA	Protein
Pseudomonas aeruginosa PACS2	Transition	g.813378A>G	p.Val372Ala	Missense GTC(Val) -> GCC(Ala)	SNP-100705	View
Pseudomonas aeruginosa PA7	Transition	g.813497C>T		Silent GAG(Glu) -> GAA(Glu)	SNP-264498	View
Pseudomonas aeruginosa PA7	Transversion	g.813511C>A	p.Asp328Tyr	Missense GAT(Asp) -> TAT(Tyr)	SNP-264499	View
Pseudomonas aeruginosa PA7	Transition	g.813545T>C		Silent GCA(Ala) -> GCG(Ala)	SNP-264500	View
Pseudomonas aeruginosa PACS2	Transition	g.813587A>G		Silent CAT(His) -> CAC(His)	SNP-100706	View

Select to view SNPs in a specific strain

SNP Map

PubMed