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               PA0870               
Key to diagram


View in GBrowse: 9 putative orthologs View metabolic pathways using PseudoCyc Acknowledgements for this annotation
Gene Information
Strain Pseudomonas aeruginosa PAO1 (Tax ID: 208964) Replicon Chromosome(5651 genes, 6264404 bp) [ RefSeq ]
Gene name phhC  Alternate Gene Names aspC, tyrB
Locus tag PA0870 (View 5 updates) Submit an Update GenBank Identifier (GI) 15596067 (Precomputed BLAST results at BLINK )
Genomic location 952161 - 950962 (-) Feature type CDS 
Transposon Mutant Available?Transposon mutant library help Yes (View in GBrowse) Pseudomonas Ortholog Group Explanation of Orthologous Groups
Product Information
Product Name aromatic amino acid aminotransferase (Class 1  Explanation of Product Name Confidence)
Alternate Product Names
Subcellular localization
Cytoplasmic (Class 1Explanation of Localization Confidence)
Cytoplasmic (Class 3Explanation of Localization Confidence)
Alternate Annotations and Cross-References
TIGR NTL03PA00871
Systomonas PA0870
RefSeq NP_249561.1
GI 15596067
KEGG PA0870
GBrowse Click here for a GBrowse View of this and other annotations.
PseudoCyc Click here to view metabolic pathways in PseudoCyc.
Operons/Regulons
Type operon
Genes
GeneProduct
phhC aromatic amino acid aminotransferase
phhB pterin-4-alpha-carbinolamine dehydratase
phhA phenylalanine-4-hydroxylase
Evidence Computationally Predicted
PubMed 18988623
Cross-Reference DOOR-13293
Function Classification / Gene Ontology (GO)
PseudoCAP Function Class Amino acid biosynthesis and metabolism
GO Accession GO Term Evidence
Molecular Function
GO:0004802 transketolase activity ISS
Biological Process
GO:0006520 amino acid metabolic process IDA
Cellular Component
COG PredictionExplanation of COG predictions
Accession Description Category
COG1448 TyrB, Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]. Amino acid transport and metabolism
Pathways
Pathways Explanation of Pathways Field
Name Database Xref
Cysteine and methionine metabolism KEGG pae00270 Computationally Generated
Tyrosine metabolism KEGG pae00350 Computationally Generated
Phenylalanine metabolism KEGG pae00360 Computationally Generated
Phenylalanine, tyrosine and tryptophan biosynthesis KEGG pae00400 Computationally Generated
Novobiocin biosynthesis KEGG pae00401 Computationally Generated
Metabolic pathways KEGG pae01100 Computationally Generated
Reactions
EC Number 2.6.1.57
Homology
BLINK Precomputed BLAST results at BLINK
Most Similar Human Homolog
ENSP00000359539, Percent Identity: 40.15%, E-Value: 2e-63, Ensembl Release: 56.
Description: Aspartate aminotransferase, cytoplasmic
Structure Features
PFAM predictions Explanation of PFAM predictions
Accession Domain Start Stop E-value Release No.
PF00155 Aminotran_1_2, Aminotransferase class I and II. 28 393 9e-71 23.0
 
Microarray Expression Data
NCBI GEO Link
Upstream 500 BP Region GGGCCTGCACGCGCCGCTGTTCCCGCCCAAGCAGGCGGCCTGACGAGAAACGCCGCCGCCGCGGCTGACCCCGCGGCGGCCTTGTACTATGGTGGACGGG CACGGCCCGTCCGCCGCTCCCACATGCGACAACCAAGGACTCCCACCATGACCGCACTCACCCAAGCCCATTGCGAAGCCTGCCGCGCAGACGCCCCGCA CGTCAGCGACGAAGAACTGCCCGTGCTGCTGCGGCAAATCCCGGATTGGAACATCGAAGTCCGCGACGGCATCATGCAGCTAGAGAAGGTCTACCTGTTC AAGAACTTCAAGCATGCCCTGGCCTTCACCAATGCCGTCGGCGAGATATCCGAGGCCGAAGGCCACCATCCGGGCCTGCTGACCGAGTGGGGCAAAGTCA CCGTGACCTGGTGGAGCCACTCGATCAAGGGCCTGCACCGCAACGATTTCATCATGGCGGCGCGCACCGATGAGGTAGCGAAAACCGCCGAGGGGCGCAA

BLAST search against this genome or other genomes in database
Need more than 500 BP? Try our sequence retrieval tool or view intergenic regions in GBrowse.

DNA Sequence ATGAGTCATTTCGCCAAGGTCGCCCGCGTACCGGGCGACCCGATCCTGGGCCTGCTCGACGCCTACCGCAACGATCCGCGCGCGGACAAGCTGGACCTCG GCGTCGGTGTCTACAAGGATGCCCAGGGCCTGACCCCGATCCTGCGCTCGGTGAAACTCGCCGAGCAGCGCCTGGTCGAGCAGGAAACCACCAAGAGCTA CGTCGGCGGCCACGGCGATGCGCTGTTCGCCGCGCGCCTGGCGGAACTGGCGCTCGGCGCCGCCTCGCCGCTGTTGCTGGAGCAACGCGCCGACGCCACC CAGACGCCCGGCGGCACCGGCGCCTTGCGCCTGGCCGGCGACTTCATCGCCCATTGCCTGCCCGGCCGCGGCATCTGGCTGAGCGACCCGACCTGGCCGA TCCACGAGACCCTGTTCGCCGCCGCCGGCCTGAAGGTTTCCCACTACCCCTACGTCAGCGCCGACAACCGCCTGGATGTCGAGGCGATGCTTGCTGGCCT GGAGCGCATTCCCCAGGGAGACGTGGTGCTGCTGCATGCCTGCTGCCACAACCCGACCGGTTTCGACCTGAGCCACGACGACTGGCGCAGGGTGCTCGAC GTGGTGCGTCGCCGCGAGCTGCTGCCGCTGATCGACTTCGCCTACCAGGGCTTCGGCGACGGTCTCGAGGAAGACGCCTGGGCGGTACGCCTGTTCGCCG GCGAACTGCCGGAGGTGCTGGTCACCAGTTCCTGCTCGAAGAACTTCGGCCTGTACCGCGACCGCGTCGGTGCGCTGATCGTCTGCGCGCAGAACGCCGA GAAGCTCACCGACCTGCGTAGCCAACTGGCCTTCCTCGCCCGCAACCTCTGGTCGACCCCGCCGGCGCATGGTGCCGAGGTGGTCGCGGCGATCCTCGGC GACAGCGAGTTGAAGGGACTCTGGCAGGAAGAGGTCGAAGGCATGCGCTCGCGCATCGCCAGCCTGCGCATCGGCCTGGTCGAAGCCCTGGCGCCGCACG GCCTGGCCGAGCGCTTCGCCCATGTCGGCGCGCAACGCGGGATGTTTTCCTATACCGGACTGAGCCCGCAGCAGGTCGCTCGGCTGCGCGACGAGCACGC CGTTTACCTGGTCTCCAGCGGCCGGGCCAACGTCGCCGGTCTCGACGCGCGCCGCCTCGACCGCCTGGCGCAAGCCATCGCCCAGGTCTGCGCGGACTGA

BLAST search against this genome or other genomes in database

Downstream 500 BP region Click here to view the nucleotide sequence of the region 500 BP downstream of this gene.
Protein Sequence MSHFAKVARVPGDPILGLLDAYRNDPRADKLDLGVGVYKDAQGLTPILRSVKLAEQRLVEQETTKSYVGGHGDALFAARLAELALGAASPLLLEQRADAT QTPGGTGALRLAGDFIAHCLPGRGIWLSDPTWPIHETLFAAAGLKVSHYPYVSADNRLDVEAMLAGLERIPQGDVVLLHACCHNPTGFDLSHDDWRRVLD VVRRRELLPLIDFAYQGFGDGLEEDAWAVRLFAGELPEVLVTSSCSKNFGLYRDRVGALIVCAQNAEKLTDLRSQLAFLARNLWSTPPAHGAEVVAAILG DSELKGLWQEEVEGMRSRIASLRIGLVEALAPHGLAERFAHVGAQRGMFSYTGLSPQQVARLRDEHAVYLVSSGRANVAGLDARRLDRLAQAIAQVCAD

BLAST search against this genome or other genomes in database
View precomputed BLAST results against all genomes at NCBI BLINK
SNPs NOTE: This feature is currently open to beta-testing. We welcome feedback on how to improve this new resource. Please send any comments to pseudocap-mail@sfu.ca.

Showing SNPs occurring in PA0870 gene of Pseudomonas aeruginosa PAO1, Chromosome (950962 to 952161 bp)


Displaying the first five SNPs out of a total of 60 found in all isolate strains ( View all 60 )
Strain Type Mutation Description Effect Details GBrowse
DNA Protein
Pseudomonas aeruginosa PA7 Transition g.950989T>C
Silent
CAA(Gln) -> CAG(Gln) 		SNP-259611 View
Pseudomonas aeruginosa PA7 Transition g.950992C>T
Silent
GCG(Ala) -> GCA(Ala) 		SNP-259612 View
Pseudomonas aeruginosa PA7 Transition g.951007G>A
Silent
CGC(Arg) -> CGT(Arg) 		SNP-259613 View
Pseudomonas aeruginosa PA7 Transition g.951058A>G
Silent
GTT(Val) -> GTC(Val) 		SNP-259614 View
Pseudomonas aeruginosa PA7 Transversion g.951062G>C p.Ala367Gly
 Missense
GCC(Ala) -> GGC(Gly) 		SNP-259615 View
Select to view SNPs in a specific strain
SNP Map
PubMed Pseudomonas aeruginosa possesses homologues of mammalian phenylalanine hydroxylase and 4 alpha-carbinolamine dehydratase/DCoH as part of a three-component gene cluster.
Zhao G, Xia T, Song J, Jensen RA.
Proc Natl Acad Sci U S A. 1994 Feb 15;91(4):1366-70.
PMID: 8108417
PhhC is an essential aminotransferase for aromatic amino acid catabolism in Pseudomonas aeruginosa.
Gu W, Song J, Bonner CA, Xie G, Jensen RA.
Microbiology. 1998 Nov;144 ( Pt 11):3127-34.
PMID: 9846749
 


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