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               PA1002               
Key to diagram


View in GBrowse: 3 putative orthologs View metabolic pathways using PseudoCyc Acknowledgements for this annotation
Gene Information
Strain Pseudomonas aeruginosa PAO1 (Tax ID: 208964) Replicon Chromosome(5651 genes, 6264404 bp) [ RefSeq ]
Gene name phnB  Alternate Gene Names
Locus tag PA1002 (View 6 updates) Submit an Update GenBank Identifier (GI) 15596199 (Precomputed BLAST results at BLINK )
Genomic location 1085542 - 1086144 (+) Feature type CDS 
Transposon Mutant Available?Transposon mutant library help Yes (View in GBrowse) Pseudomonas Ortholog Group Explanation of Orthologous Groups
Product Information
Product Name anthranilate synthase component II (Class 1  Explanation of Product Name Confidence)
Alternate Product Names phenazine biosynthesis protein PhnB
Subcellular localization
Cytoplasmic (Class 3Explanation of Localization Confidence)
Alternate Annotations and Cross-References
TIGR NTL03PA01003
Systomonas PA1002
RefSeq NP_249693.1
GI 15596199
KEGG PA1002
GBrowse Click here for a GBrowse View of this and other annotations.
PseudoCyc Click here to view metabolic pathways in PseudoCyc.
Operons/Regulons
Type operon
Genes
GeneProduct
phnA anthranilate synthase component I
phnB anthranilate synthase component II
Evidence Computationally Predicted
PubMed 18988623
Cross-Reference DOOR-13318
Genomic Context
Genomic context Explanation of Genomic Context Field - phnA just upstream. PhnB and A known to be cotranscribed.
Function Classification / Gene Ontology (GO)
PseudoCAP Function Class Amino acid biosynthesis and metabolism
Adaptation, Protection
GO Accession GO Term Evidence
Molecular Function
GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor IEA
Biological Process
GO:0006520 amino acid metabolic process IDA
GO:0050896 response to stimulus IDA
GO:0006558 L-phenylalanine metabolic process IDA
GO:0000162 tryptophan biosynthetic process IDA
GO:0006570 tyrosine metabolic process IDA
GO:0006744 ubiquinone biosynthetic process IDA
Cellular Component
COG PredictionExplanation of COG predictions
Accession Description Category
COG0512 PabA, Anthranilate/para-aminobenzoate synthases component II [Amino acid transport and metabolism / Coenzyme metabolism]. Amino acid transport and metabolism / Coenzyme metabolism
Pathways
Pathways Explanation of Pathways Field
Name Database Xref
Ubiquinone biosynthesis PseudoCAP
Phenylalanine, tyrosine and tryptophan biosynthesis PseudoCAP
phenylalanine, tyrosine and tryptophan biosynthesis, complete PseudoCyc COMPLETE-ARO-PWY
tryptophan biosynthesis PseudoCyc TRPSYN-PWY
pathways of chorismate PseudoCyc ALL-CHORISMATE-PWY
Phenylalanine, tyrosine and tryptophan biosynthesis KEGG pae00400 Computationally Generated
Metabolic pathways KEGG pae01100 Computationally Generated
Homology
BLINK Precomputed BLAST results at BLINK
Homologs Explanation of Homologs Field 99% identical to anthranilate synthase beta subunit [Pseudomonas aeruginosa]
Structure Features
Structure Features Explanation of Structure Features Field BL00442: Glutamine amidotransferases class-I proteins
PFAM predictions Explanation of PFAM predictions
Accession Domain Start Stop E-value Release No.
PF00117 GATase, Glutamine amidotransferase class-I. 5 189 5e-48 23.0
PF07722 Peptidase_C26, Peptidase C26. 66 171 5e-08 23.0
 
Microarray Expression Data
NCBI GEO Link
Upstream 500 BP Region GGACGCCAAGGAGATCGCCGAGCACATGATGCTGGTCGACCTGGCGCGCAACGATCTGGCGCGGGTCTGCCGCAGCGGTACGCGGCAGGTGCGCGACATG CTCAAGGTCGATCGCTACAGCCACGTGATGCACCTGGTCTCGCGCGTGGCTGGCGAACTGCATGGCGAACTGGATGCGCTGCATGCCTACCGTGCCTGCC TGAACATGGGCACCTTGGTCGGTGCGCCGAAGGTCCGTGCCATGCAGTTGCTGCGGCAGTACGAAGATGGCTATCGCGGCAGCTACGGTGGCGCGATCGG CATTCTCGACAGCGCCGGCAACCTCGATACCAGCATCGTCATCCGCTCCGCCGAGGTCCGCGAAGGTATCGCCCGGGTCCGGGCAGGCGCCGGCGTGGTG CTGGATTCGGATCCACGGCTGGAGGCCGAGGAAACCCGCAACAAGGCGCTGGCGGTGCTGACCGCCGTGGCCGCTGCCGAACGCGAAAGGGGAGAGCGCG

BLAST search against this genome or other genomes in database
Need more than 500 BP? Try our sequence retrieval tool or view intergenic regions in GBrowse.

DNA Sequence ATGCGCATCACGCTGTTGGATAACTTCGATTCCTTCACCTACAACCTGGTCGAGCAGTTCTGCCTGCTCGGCGCGGAGGTCCGGGTGATGCGCAACGATA CGCCGTTGCCGACGATCCAGGCGGCATTGCTGGCCGACGGTTGCGAACTGCTGGTGCTGTCGCCGGGGCCCGGTCGGCCGGAAGACGCCGGCTGCATGCT GGAATTGCTCGCCTGGGCCCGCGGGCGCTTGCCGGTGCTCGGCGTCTGCCTCGGCCACCAGGCGCTGGCGCTGGCCGCCGGTGGCGCGGTGGGCGAGGCG AGGAAGCCGCTGCACGGCAAGAGCACGTCCCTGCGTTTCGATCAGCGTCACCCGCTGTTCGACGGCATCGCTGACCTGCGCGTCGCGCGCTACCACTCGC TGGTGGTCAGTCGCCTGCCGGAAGGTTTCGACTGCCTGGCCGATGCCGATGGCGAGATCATGGCGATGGCCGATCCGCGCAATCGACAGCTGGGCTTGCA GTTCCATCCCGAGTCGATTCTCACCACCCACGGCCAGCGTCTGCTGGAGAACGCTCTACTCTGGTGCGGCGCGCTGGCGGTACGCGAGCGCCTTCGGGCC TGA

BLAST search against this genome or other genomes in database

Downstream 500 BP region Click here to view the nucleotide sequence of the region 500 BP downstream of this gene.
Protein Sequence MRITLLDNFDSFTYNLVEQFCLLGAEVRVMRNDTPLPTIQAALLADGCELLVLSPGPGRPEDAGCMLELLAWARGRLPVLGVCLGHQALALAAGGAVGEA RKPLHGKSTSLRFDQRHPLFDGIADLRVARYHSLVVSRLPEGFDCLADADGEIMAMADPRNRQLGLQFHPESILTTHGQRLLENALLWCGALAVRERLRA

BLAST search against this genome or other genomes in database
View precomputed BLAST results against all genomes at NCBI BLINK
SNPs NOTE: This feature is currently open to beta-testing. We welcome feedback on how to improve this new resource. Please send any comments to pseudocap-mail@sfu.ca.

Showing SNPs occurring in PA1002 gene of Pseudomonas aeruginosa PAO1, Chromosome (1085542 to 1086144 bp)


Displaying the first five SNPs out of a total of 65 found in all isolate strains ( View all 65 )
Strain Type Mutation Description Effect Details GBrowse
DNA Protein
Pseudomonas aeruginosa PA14 Transition g.1085592C>T
Silent
GTC(Val) -> GTT(Val) 		SNP-136707 View
Pseudomonas aeruginosa PA7 Transversion g.1085610C>G
Silent
CTC(Leu) -> CTG(Leu) 		SNP-479416 View
Pseudomonas aeruginosa PA7 Transversion g.1085616G>C
Silent
GCG(Ala) -> GCC(Ala) 		SNP-479417 View
Pseudomonas aeruginosa PA7 Transversion g.1085622C>G
Silent
GTC(Val) -> GTG(Val) 		SNP-479418 View
Pseudomonas aeruginosa PA7 Transition g.1085640T>C
Silent
GAT(Asp) -> GAC(Asp) 		SNP-479419 View
Select to view SNPs in a specific strain
SNP Map
PubMed Identification and characterization of genes for a second anthranilate synthase in Pseudomonas aeruginosa: interchangeability of the two anthranilate synthases and evolutionary implications.
Essar DW, Eberly L, Hadero A, Crawford IP.
J Bacteriol. 1990 Feb;172(2):884-900.
PMID: 2153661
 


We thank Cystic Fibrosis Foundation Therapeutics, Inc. for critical funding support for the Pseudomonas Genome Database. When acknowledging use of the database, please cite the article by Winsor et al. (2009; PMID:18978025) and not the web site URL. Thank you!

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