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               PA1338               
Key to diagram


View in GBrowse: (?) 15 putative orthologs View metabolic pathways using PseudoCyc Acknowledgements for this annotation
Gene Information
Strain Pseudomonas aeruginosa PAO1 (Tax ID: 208964) Replicon Chromosome(5651 genes, 6264404 bp) [ RefSeq ]
Gene name ggt  Alternate Gene Names
Locus tag PA1338 (View 12 updates) GenBank Identifier (GI) 15596535 (Precomputed BLAST results at BLINK )
Genomic location 1453392 - 1451719 (-) Feature type CDS 
Transposon Mutant Available?Transposon mutant library help Yes (View in GBrowse) Pseudomonas Ortholog Group Explanation of Orthologous Groups
Product Information
Product Name gamma-glutamyltranspeptidase precursor (Class 2  Explanation of Product Name Confidence)
Alternate Product Names
Subcellular localization
Periplasmic (Class 2Explanation of Localization Confidence)
Periplasmic (Class 3Explanation of Localization Confidence)
Function Classification / Gene Ontology (GO)
PseudoCAP Function Class Amino acid biosynthesis and metabolism
Adaptation, Protection
Central intermediary metabolism
GO Accession GO Term Evidence
Molecular Function
GO:0003840 gamma-glutamyltransferase activity IEA
Biological Process
GO:0006520 amino acid metabolic process ISS
GO:0050896 response to stimulus ISS
GO:0008152 metabolic process ISS
GO:0006750 glutathione biosynthetic process IEA
Cellular Component
COG PredictionExplanation of COG predictions
Accession Description Category
COG0405 Ggt, Gamma-glutamyltransferase [Amino acid transport and metabolism]. Amino acid transport and metabolism
Pathways
Pathways Explanation of Pathways Field
Name Database Xref
Taurine and hypotaurine metabolism PseudoCAP
Selenoamino acid metabolism PseudoCAP
Glutathione metabolism PseudoCAP
Cyanoamino acid metabolism PseudoCAP
Taurine and hypotaurine metabolism KEGG pae00430 Computationally Generated
Selenoamino acid metabolism KEGG pae00450 Computationally Generated
Cyanoamino acid metabolism KEGG pae00460 Computationally Generated
Glutathione metabolism KEGG pae00480 Computationally Generated
Arachidonic acid metabolism KEGG pae00590 Computationally Generated
Metabolic pathways KEGG pae01100 Computationally Generated
Reactions
EC Number 2.3.2.2
Homology
BLINK Precomputed BLAST results at BLINK
Homologs Explanation of Homologs Field 62% similar to gamma-glutamyltranspeptidase [Escherichia coli]
Most Similar Human Homolog
ENSP00000405534, Percent Identity: 34.02%, E-Value: 5e-53, Ensembl Release: 56.
Description: Gamma-glutamyltranspeptidase 1 Precursor
Structure Features
Structure Features Explanation of Structure Features Field PS00462: Gamma-glutamyltranspeptidase signature
type I export signal computationally predicted by LipoP v.1.0 (cleavage after residue 24)
type I export signal computationally predicted by Phobius (cleavage after residue 24)
type I export signal computationally predicted by SignalP v.3.0 Hidden Markov Models (cleavage after residue 24)
PFAM predictions Explanation of PFAM predictions
Accession Domain Start Stop E-value Release No.
PF01019 G_glu_transpept, Gamma-glutamyltranspeptidase. 44 548 1e-174 23.0
 
Microarray Expression Data
NCBI GEO Link
Sequence data
Upstream 500 BP Region GTACTCGGCCGCAGCAAGGAAGAAGCCACCAAGAAGGGCCTGGCCCTGCTCGAGCGTGTCGGTCTCAAGGAGCACGCGCACAAGCACCCCGGCCAGCTCT CCGGCGGCCAGCAGCAGCGCGTGGCGATCGCCCGCGCGCTGGCGATGGACCCGGTGGTGATGCTGTTCGACGAGCCGACCTCGGCGCTCGACCCGGAAAT GGTCAACGAAGTGCTCGACGTGATGGTCCAGCTGGCCCACGAAGGCATGACCATGATGTGCGTGACCCACGAGATGGGCTTCGCGCGCAAGGTCGCCAAC CGGGTGATCTTCATGGACCGCGGGCAGATCGTGGAAGACTGCGAGAAGGAGGAGTTCTTCGGCGACGTCAGCGCCCGCTCCGAACGCGCCCAGCAGTTCC TCGCCAAGATCCTCCCGCACTGATGTACCCGCCCTCGCCGGCCCGCCCGGCGGGGGCCTGCTCCACCCTCGCCTGCGATAACAATAAATAGGGAAAGCCC

BLAST search against this genome or other genomes in database
Need more than 500 BP? Try our sequence retrieval tool or view intergenic regions in GBrowse.

DNA Sequence ATGCAACCTGTGCTCTTCAGAACCCTGTCCCTCGGCGTCGCCATTGCCGCCGCATCCTCCTCGGCCTTCGCCGCCACGCTCGACGGCGGCGCCGTCGCCG CGCCCGACGAGTACGGCGCCAAGGTCGCCGCGCAGATCCTCAAGGCCGGCGGCAACGCGGTGGACGCCGCGGTGGCCACCGCCTTCACCCTGGCGGTCAC CTACCCCGAGGCCGGCAACATCGGCGGCGGCGGCTTCATGACCCTGTACATGGACGGCAAGCCGTACTTCCTCGACTACCGCGAGGTGGCGCCGAAGGCC GCGAGCAAGACCATGTACCTGGACGACAAGGGCGAGGTGATCGAGAACCTCAGCCTGGTCGGCGCCAAGGCCGCCGGCGTGCCGGGCACCGTGATGGGCC TCTGGGAAGCCCACAAGCGGTTCGGCAAGCTGCCCTGGAGCGAGCTGCTGACCCCGGCCATCGGCTACGCGCAAAAGGGCTTCAAGGTCGCCGACAAGCA GTTCCAGTACCGCCAGGACGCCGTCGCCCTGTTCAACGGCAAGACCAACTTCGGCGACTACTTCGGCCACATGAAGGCCGGCGAGGCGTTCCTCCAGCCG GACCTGGCGAAGACCCTGGAGCGTATCGCCGACAAGGGCCCGGACGAGTTCTACAAAGGCCATACCGCCGACCTGCTGGTGGCACAGATGCAGCAGGACA AGGGACTGATCACCCACCAGGACCTCGCCGACTACAAGGTCAGGTGGCGCGAACCGATGCGCGTCGACTGGCAGGGCAACACGCTCTATACCGCGCCGCT GCCAAGCTCCGGCGGGATCGCCCTGGCCCAGTTGCTGGGCATCAAGGAAAACCGTGCCGCCGACTTCAAGGGCGTCGAGCTGAACTCCGCGCGCTACATC CACCTGCTGGCGGAGATCGAGAAACGCGTGTTCGCCGACCGCGCCGACTACCTCGGCGACCCGGACTTCTCCAAGGTCCCGGTGGCGCGCCTGACCGATC CGGCATACCTGAAGCAGCGTGCCGCCGAGGTCAATCCGACGGCGATCTCGCCGACCGAGAAGGTCCGTCCCGGCCTGGAGCCGCACCAGACCACGCACTT CTCCATCGTCGACGCCGACGGCAACGCGGTGAGCAACACCTACACCCTCAACTGGGACTTCGGCAGCGGCGTGGTGGTCAAGGGCGCCGGCTTCCTGCTC AACGACGAGATGGACGACTTTAGCGCCAAACCGGGCGTGGCCAACGCCTTCGGCGTGGTCGGCAGCGACGCCAACGCCATCGAGCCGGGCAAGCGCATGC TCTCCTCGATGAGCCCGAGCATCGTCACCCGCGACGGCAAGGTCAGCCTGGTGGTCGGCACTCCCGGCGGCTCGCGGATCTTCACCTCGATCTTCCAGGT GCTGAACAACATCTACGACTTCCACCTGCCGCTGGAGAAGGCCGTGGCCGCGCAGCGCGTGCACCACCAGTTGCTGCCCAAGGACACGATCTACTACGAC GCCTACGCGCCGCTCGCCGGCAAGGTCGCCGAGGAGCTGAAGGCGATGGGCTACACCCTGGAGGACCAGGGCTGGAACATGGGCGATATCCAGGCCATCC GCGTCGACGGCAAGGCCCTGGAGACCGCCTCCGATCCCCGTGGCCGCGGCGTCGGCCTGGTGGTGAAACCCTGA

BLAST search against this genome or other genomes in database


Downstream 500 BP region Click here to view the nucleotide sequence of the region 500 BP downstream of this gene.

Protein Sequence MQPVLFRTLSLGVAIAAASSSAFAATLDGGAVAAPDEYGAKVAAQILKAGGNAVDAAVATAFTLAVTYPEAGNIGGGGFMTLYMDGKPYFLDYREVAPKA ASKTMYLDDKGEVIENLSLVGAKAAGVPGTVMGLWEAHKRFGKLPWSELLTPAIGYAQKGFKVADKQFQYRQDAVALFNGKTNFGDYFGHMKAGEAFLQP DLAKTLERIADKGPDEFYKGHTADLLVAQMQQDKGLITHQDLADYKVRWREPMRVDWQGNTLYTAPLPSSGGIALAQLLGIKENRAADFKGVELNSARYI HLLAEIEKRVFADRADYLGDPDFSKVPVARLTDPAYLKQRAAEVNPTAISPTEKVRPGLEPHQTTHFSIVDADGNAVSNTYTLNWDFGSGVVVKGAGFLL NDEMDDFSAKPGVANAFGVVGSDANAIEPGKRMLSSMSPSIVTRDGKVSLVVGTPGGSRIFTSIFQVLNNIYDFHLPLEKAVAAQRVHHQLLPKDTIYYD AYAPLAGKVAEELKAMGYTLEDQGWNMGDIQAIRVDGKALETASDPRGRGVGLVVKP

BLAST search against this genome or other genomes in database
View precomputed BLAST results against all genomes at NCBI BLINK
References
PubMed Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE.
Genome Res. 2005 Feb;15(2):321-9.
PMID: 15687295
Molecular cloning of Escherichia coli K-12 ggt and rapid isolation of gamma-glutamyltranspeptidase.
Suzuki H, Kumagai H, Echigo T, Tochikura T.
Biochem Biophys Res Commun. 1988 Jan 15;150(1):33-8.
PMID: 2892489
DNA sequence of the Escherichia coli K-12 gamma-glutamyltranspeptidase gene, ggt.
Suzuki H, Kumagai H, Echigo T, Tochikura T.
J Bacteriol. 1989 Sep;171(9):5169-72.
PMID: 2570061
Escherichia coli gamma-glutamyltranspeptidase mutants deficient in processing to subunits.
Hashimoto W, Suzuki H, Nohara S, Kumagai H.
Biochem Biophys Res Commun. 1992 Nov 30;189(1):173-8.
PMID: 1360205
 
Alternate Annotations and Cross-References
TIGR NTL03PA01339
Systomonas PA1338
RefSeq NP_250029.1
GI 15596535
KEGG PA1338
GBrowse Click here for a GBrowse View of this and other annotations.
PseudoCyc Click here to view metabolic pathways in PseudoCyc.


We thank Cystic Fibrosis Foundation Therapeutics, Inc. for critical funding support for the Pseudomonas Genome Database. When acknowledging use of the database, please cite the article by Winsor et al. (2009; PMID:18978025) and not the web site URL. Thank you!

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