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               PA2832               
Key to diagram


View in GBrowse: 15 putative orthologs View metabolic pathways using PseudoCyc Acknowledgements for this annotation
Gene Information
Strain Pseudomonas aeruginosa PAO1 (Tax ID: 208964) Replicon Chromosome(5651 genes, 6264404 bp) [ RefSeq ]
Gene name tpm  Alternate Gene Names
Locus tag PA2832 (View 3 updates) Submit an Update GenBank Identifier (GI) 15598028 (Precomputed BLAST results at BLINK )
Genomic location 3185817 - 3185161 (-) Feature type CDS 
Transposon Mutant Available?Transposon mutant library help Yes (View in GBrowse) Pseudomonas Ortholog Group Explanation of Orthologous Groups
Product Information
Product Name thiopurine methyltransferase (Class 2  Explanation of Product Name Confidence)
Alternate Product Names
Subcellular localization
Cytoplasmic (Class 3Explanation of Localization Confidence)
Alternate Annotations and Cross-References
TIGR NTL03PA02832
Systomonas PA2832
RefSeq NP_251522.1
GI 15598028
KEGG PA2832
GBrowse Click here for a GBrowse View of this and other annotations.
PseudoCyc Click here to view metabolic pathways in PseudoCyc.
Function Classification / Gene Ontology (GO)
PseudoCAP Function Class Nucleotide biosynthesis and metabolism
Adaptation, Protection
GO Accession GO Term Evidence
Molecular Function
GO:0008802 betaine-aldehyde dehydrogenase activity ISS
Biological Process
GO:0050896 response to stimulus ISS
GO:0009117 nucleotide metabolic process ISS
GO:0046690 response to tellurium ion RCA
Cellular Component
Reactions
EC Number 2.1.1.67
Homology
BLINK Precomputed BLAST results at BLINK
Homologs Explanation of Homologs Field 51% similar to thiopurine S-methyltransferase [Rattus norvegicus]
63% similar to thiopurine methyltransferase [Pseudomonas syringae]
Most Similar Human Homolog
ENSP00000312304, Percent Identity: 30.91%, E-Value: 9e-23, Ensembl Release: 56.
Description: Thiopurine S-methyltransferase
Structure Features
PFAM predictions Explanation of PFAM predictions
Accession Domain Start Stop E-value Release No.
PF05724 TPMT, Thiopurine S-methyltransferase (TPMT). 16 218 8e-78 23.0
 
Microarray Expression Data
NCBI GEO Link
Upstream 500 BP Region GTTCCATACGCTCCTGGTCGCCATCGACGGCGGCCCGCAGACCCGTCGCATTGCCGAGCTGGCGCGGCAGGCCGCCGCGCCGGGCGCGCGGGTCCACCTG CTGTGCGCGGTGGACGCCGGCTATGCGTTGCCGGGCCGGCCGACGCTGCTCGACTATCCGCCCGCCGCGCACGAGTGCGAAGAGGCCCGGCAGGTGCTCG ACGAGGCCCGTGCGCTGCTAGCCGGGTGCGAGCTGGAGGTACGGGCCGAGCTGCGCGCCGGCGACCCGGTGCAGGTGATCCTGGGCGAGGCGCGACGCCT GGGCTGCGAGCTGATCGTCATCGGTCATCGGCACCTGGGGCGGCTGGAGCGCCTGCTCGATCCTTCGGTCGGCGACCGGGTGATCCGCGAGGCGCCGTGT CCGGTGCTGGTGGAAGTGCGCGAGGGAGATGCGCAGGGGAGTTGACCTGCCGGCCGATTGTCGCCACCTTGCGGTTTTTCCCACGAATGCGGAGGACAGG

BLAST search against this genome or other genomes in database
Need more than 500 BP? Try our sequence retrieval tool or view intergenic regions in GBrowse.

DNA Sequence ATGCAGGCGGATTTTTGGCACGCCCGCTGGGCGAACAACCAGATCGGCTTCCACCTGGACGAGATCAATCCCTACCTGATGCGCCACCTGTCGCGGCTGC GACTGCAAGCGGGCGAACAGATCCTGGTGCCGTTGTGCGGCAAGACCCTGGACCTGGCCTGGCTGGCCGCCCAGGGACTGGAGGTGCTGGGGGTGGAGCT TTCGGAAAAGGCCGTGAGCGACTTCTTCGAGGAGCACGACCTGCACCCCGAGATCGATCAACTGGATGGTTTCCGCCGCTACCGGGTCGCCGGCATCACC CTGCTGCAGGGTGATTTCTTCGCCTTGCAGGCAGAGCACCTGGCGCAGTGCAGGGCGTTCTACGACCGCGCCGCGCTGATCGCCCTGCCGCCGGAGATGC GCGAGCGCTATGCCGGGCATCTCCAGGCGGTCCTGCCGACGCGCAGCCTCGGCTTGCTGGTCACCATCGACTACCCGCAGGCGGAGATGGCCGGTCCGCC GTTCGCCGTGCCCGACGAGGAGGTGCGTGGCTACTACGCTGGCGGTTGGCGGATCGAGGAACTGGAGCGCGGCGACGTGCTCGGCGTCAACTGGAAATTC CTCGAGCGCGGGGTGTCCTGGCTGGACGAGGCCGTCTACCTGCTGGAGAGAGGCTGA

BLAST search against this genome or other genomes in database

Downstream 500 BP region Click here to view the nucleotide sequence of the region 500 BP downstream of this gene.
Protein Sequence MQADFWHARWANNQIGFHLDEINPYLMRHLSRLRLQAGEQILVPLCGKTLDLAWLAAQGLEVLGVELSEKAVSDFFEEHDLHPEIDQLDGFRRYRVAGIT LLQGDFFALQAEHLAQCRAFYDRAALIALPPEMRERYAGHLQAVLPTRSLGLLVTIDYPQAEMAGPPFAVPDEEVRGYYAGGWRIEELERGDVLGVNWKF LERGVSWLDEAVYLLERG

BLAST search against this genome or other genomes in database
View precomputed BLAST results against all genomes at NCBI BLINK
SNPs NOTE: This feature is currently open to beta-testing. We welcome feedback on how to improve this new resource. Please send any comments to pseudocap-mail@sfu.ca.

Showing SNPs occurring in PA2832 gene of Pseudomonas aeruginosa PAO1, Chromosome (3185161 to 3185817 bp)


Displaying the first five SNPs out of a total of 82 found in all isolate strains ( View all 82 )
Strain Type Mutation Description Effect Details GBrowse
DNA Protein
Pseudomonas aeruginosa PA7 Transition g.3185164G>A
Silent
GGC(Gly) -> GGT(Gly) 		SNP-338426 View
Pseudomonas aeruginosa PA7 Transversion g.3185172C>G p.Glu216Gln
 Missense
GAG(Glu) -> CAG(Gln) 		SNP-338427 View
Pseudomonas aeruginosa PA7 Transition g.3185188C>T
Silent
GAG(Glu) -> GAA(Glu) 		SNP-338428 View
Pseudomonas aeruginosa C3719 Transition g.3185193C>T p.Asp209Asn
 Missense
GAC(Asp) -> AAC(Asn) 		SNP-6900 View
Pseudomonas aeruginosa 2192 Transition g.3185193C>T p.Asp209Asn
 Missense
GAC(Asp) -> AAC(Asn) 		SNP-52763 View
Select to view SNPs in a specific strain
SNP Map
PubMed A tellurite-resistance genetic determinant from phytopathogenic pseudomonads encodes a thiopurine methyltransferase: evidence of a widely-conserved family of methyltransferases.
Cournoyer B, Watanabe S, Vivian A.
Biochim Biophys Acta. 1998 Apr 29;1397(2):161-8.
PMID: 9565678
 


We thank Cystic Fibrosis Foundation Therapeutics, Inc. for critical funding support for the Pseudomonas Genome Database. When acknowledging use of the database, please cite the article by Winsor et al. (2009; PMID:18978025) and not the web site URL. Thank you!

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