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               PA3182               
Key to diagram


View in GBrowse: (?) 16 putative orthologs View metabolic pathways using PseudoCyc Acknowledgements for this annotation
Gene Information
Strain Pseudomonas aeruginosa PAO1 (Tax ID: 208964) Replicon Chromosome(5651 genes, 6264404 bp) [ RefSeq ]
Gene name pgl  Alternate Gene Names
Locus tag PA3182 (View 6 updates) GenBank Identifier (GI) 15598378 (Precomputed BLAST results at BLINK )
Genomic location 3572337 - 3571621 (-) Feature type CDS 
Transposon Mutant Available?Transposon mutant library help Yes (View in GBrowse) Pseudomonas Ortholog Group Explanation of Orthologous Groups
Product Information
Product Name 6-phosphogluconolactonase (Class 1  Explanation of Product Name Confidence)
Alternate Product Names
Subcellular localization
Unknown (Class 3Explanation of Localization Confidence)
Function Classification / Gene Ontology (GO)
PseudoCAP Function Class Central intermediary metabolism
GO Accession GO Term Evidence
Molecular Function
GO:0017057 6-phosphogluconolactonase activity IEA
Biological Process
GO:0008152 metabolic process IDA
GO:0006098 pentose-phosphate shunt IEA
Cellular Component
COG PredictionExplanation of COG predictions
Accession Description Category
COG0363 NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]. Carbohydrate transport and metabolism
TIGRFAM predictionExplanation of TIGRFAM predictions
Accession Name Function Significance Role Sub Role Release No.
TIGR01198 pgl 6-phosphogluconolactonase 2.6e-107 Energy metabolism Pentose phosphate pathway 8.0
Pathways
Pathways Explanation of Pathways Field
Name Database Xref
Pentose phosphate pathway KEGG pae00030 Computationally Generated
Metabolic pathways KEGG pae01100 Computationally Generated
Homology
BLINK Precomputed BLAST results at BLINK
Homologs Explanation of Homologs Field 60% similar to putative oxidoreductase DevB [Sinorhizobium meliloti]
100% identical to putative 6-phosphogluconolactonase [Pseudomonas aeruginosa]
Most Similar Human Homolog
ENSP00000366620, Percent Identity: 28.32%, E-Value: 4e-11, Ensembl Release: 56.
Description: GDH/6PGL endoplasmic bifunctional protein Precursor
Structure Features
PFAM predictions Explanation of PFAM predictions  
Genomic Context
Genomic context Explanation of Genomic Context Field - Part of a cluster of genes in the Entner -Douderoff pathway, regulated by hexR (PA3184)
Operons/Regulons
Type operon
Genes
GeneProduct
PA3181 2-keto-3-deoxy-6-phosphogluconate aldolase
pgl 6-phosphogluconolactonase
zwf glucose-6-phosphate 1-dehydrogenase
Evidence Computationally Predicted
PubMed 18988623
Cross-Reference DOOR-13763
Microarray Expression Data
NCBI GEO Link
Sequence data
Upstream 500 BP Region GGACATCCGCAACTGGCGCTGGTCGGGCGTGCCGTTCTACCTGCGCACCGGCAAGCGCATGCCGCAGAAGCTGTCGCAGATCGTCATCCACTTCAAGGAG CCGCCGCACTACATCTTCGCTCCCGAGCAGCGTTCGCTGATCAGCAACCGGCTGATCATCCGCCTGCAGCCGGACGAAGGTATCTCCCTGCAAGTGATGA CCAAGGACCAGGGCCTGGGCAAGGGCATGCAATTGCGTACCGGCCCGCTGCAACTGAGTTTTTCCGAGACCTACCACGCGGCGCGGATTCCCGATGCCTA CGAGCGTCTGCTGCTGGAGGTCACCCAGGGCAACCAGTACCTGTTCGTGCGCAAGGACGAGGTGGAGTTCGCCTGGAAGTGGTGCGACCAGCTGATCGCT GGCTGGGAACGCCTGAGCGAAGCGCCCAAGCCGTATCCGGCGGGGAGTTGGGGGCCGGTGGCCTCGGTGGCCCTGGTGGCCCGCGATGGGAGGAGTTGGT

BLAST search against this genome or other genomes in database
Need more than 500 BP? Try our sequence retrieval tool or view intergenic regions in GBrowse.

DNA Sequence ATGGCGATTTCTGAGTTGAAGCTGCCGGCCGGCGTCGGCCTGCAGGTCTGGGGCAGCGCCGCCGAGCAGGCCCGCGGCCTGGCCGCCGAGGTCGCCGGCC GGTTGCGCTCGGCGCTGGCCGAGCAGGGCCAGGCGCTGCTGGTGGTGTCCGGTGGGCGCAGTCCGGTGGCCTTCCTCGAAGCCTTGAGCGAGGAGCCGCT GGACTGGTCGCGGATCACAGTCAGCCTGGCCGACGAGCGCTGGGTGCCGGAGTCGCATGCCGATAGCAACGCCGGCCTGGTTCGCCGCCACCTGCTCCGT GGCGAGGCGGCGAAGGCGCGCTTCATCGGCCTCTACCAGCCGGCGGCGAGCCTGGAGGAAGCGGCCGAGCTGGCCGACCATCACCTGCACGAGCTGCCAT TGCCGATCGACGTGCTGGTCCTCGGCATGGGCGACGACGGCCATACCGCCTCGCTGTTCCCGAACAGCCCTGGCCTGGACCTGGCGATGGATCCCCAGGG GACGCGCCGTTGCCTGCCGATGTGGGCGCCGAGCGTGCCGCACCAGCGCCTGACCCTGCCGCGCGCCGTGCTGGCGGCGGCGAAGGTGCAGCTGCTGGCG ATCCAGGGCCAGTCCAAGCTGGCCACCCTGAACGCCGCGCTGGCGGTCGAGGACGAACGGCGGATGCCGGTTCGCGCCTTCCTCCGCGCGCCGCTGACGA TCCATTGGTACCCCTGA

BLAST search against this genome or other genomes in database


Downstream 500 BP region Click here to view the nucleotide sequence of the region 500 BP downstream of this gene.

Protein Sequence MAISELKLPAGVGLQVWGSAAEQARGLAAEVAGRLRSALAEQGQALLVVSGGRSPVAFLEALSEEPLDWSRITVSLADERWVPESHADSNAGLVRRHLLR GEAAKARFIGLYQPAASLEEAAELADHHLHELPLPIDVLVLGMGDDGHTASLFPNSPGLDLAMDPQGTRRCLPMWAPSVPHQRLTLPRAVLAAAKVQLLA IQGQSKLATLNAALAVEDERRMPVRAFLRAPLTIHWYP

BLAST search against this genome or other genomes in database
View precomputed BLAST results against all genomes at NCBI BLINK
References
PubMed The Pseudomonas aeruginosa devB/SOL homolog, pgl, is a member of the hex regulon and encodes 6-phosphogluconolactonase.
Hager PW, Calfee MW, Phibbs PV.
J Bacteriol. 2000 Jul;182(14):3934-41.
PMID: 10869070
 
Alternate Annotations and Cross-References
TIGR NTL03PA03182
Systomonas PA3182
RefSeq NP_251872.1
GI 15598378
KEGG PA3182
GBrowse Click here for a GBrowse View of this and other annotations.
PseudoCyc Click here to view metabolic pathways in PseudoCyc.


We thank Cystic Fibrosis Foundation Therapeutics, Inc. for critical funding support for the Pseudomonas Genome Database. When acknowledging use of the database, please cite the article by Winsor et al. (2009; PMID:18978025) and not the web site URL. Thank you!

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