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               PA3506               
Key to diagram


View in GBrowse: View metabolic pathways using PseudoCyc Acknowledgements for this annotation
Gene Information
Strain Pseudomonas aeruginosa PAO1 (Tax ID: 208964) Replicon Chromosome(5651 genes, 6264404 bp) [ RefSeq ]
Gene name   Alternate Gene Names
Locus tag PA3506 (View 5 updates) Submit an Update GenBank Identifier (GI) 15598702 (Precomputed BLAST results at BLINK )
Genomic location 3923766 - 3922084 (-) Feature type CDS 
Transposon Mutant Available?Transposon mutant library help Yes (View in GBrowse) Pseudomonas Ortholog Group Explanation of Orthologous Groups
 
Product Information
Product Name probable decarboxylase (Class 3  Explanation of Product Name Confidence)
Alternate Product Names
Subcellular localization
Cytoplasmic (Class 3Explanation of Localization Confidence)
Alternate Annotations and Cross-References
TIGR NTL03PA03506
Systomonas PA3506
RefSeq NP_252196.1
GI 15598702
KEGG PA3506
GBrowse Click here for a GBrowse View of this and other annotations.
PseudoCyc Click here to view metabolic pathways in PseudoCyc.
Function Classification / Gene Ontology (GO)
PseudoCAP Function Class Putative enzymes
GO Accession GO Term Evidence
Molecular Function
GO:0003984 acetolactate synthase activity IEA
Biological Process
GO:0009097 isoleucine biosynthetic process IEA
GO:0009099 valine biosynthetic process IEA
Cellular Component
GO:0005948 acetolactate synthase complex IEA
COG PredictionExplanation of COG predictions
Accession Description Category
COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]. acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism
TIGRFAM predictionExplanation of TIGRFAM predictions
Accession Name Function Significance Role Sub Role Release No.
TIGR00118 acolac_lg acetolactate synthase, large subunit, biosynthetic type 2e-17 Amino acid biosynthesis Pyruvate family 8.0
Homology
BLINK Precomputed BLAST results at BLINK
Homologs Explanation of Homologs Field 44% similar to acetolactate synthase [Arabidopsis thaliana]
Most Similar Human Homolog
ENSP00000263383, Percent Identity: 24.50%, E-Value: 1e-15, Ensembl Release: 56.
Description: Acetolactate synthase-like protein
Structure Features
Structure Features Explanation of Structure Features Field PS00187: Thiamine pyrophosphate enzymes signature
PFAM predictions Explanation of PFAM predictions
Accession Domain Start Stop E-value Release No.
PF02776 TPP_enzyme_N, Thiamine pyrophosphate enzyme, N-terminal TPP binding domain. 8 179 6e-31 23.0
PF00205 TPP_enzyme_M, Thiamine pyrophosphate enzyme, central domain. 197 326 1e-16 23.0
PF02775 TPP_enzyme_C, Thiamine pyrophosphate enzyme, C-terminal TPP binding domain. 386 533 2e-28 23.0
 
Microarray Expression Data
NCBI GEO Link
Upstream 500 BP Region GGGCCGCGTCTCGACCTTCGCCGAGACCACGGACGAGGCCTGGAGCGAGGAACTGCAACTGAAGTTCTTTTCCGTCATCCACCCGGTACGCGCTTTCCTG CCGCAACTGGAAAGCCGCGCCGACGCGGCCATCGTCTGCGTCAACTCGCTGCTGGCCAGCCAGCCGGAGCCGCACATGGTGGCTACCAGCGCGGCCCGCG CCGGGGTGAAGAACCTGGTGCGCTCCATGGCCTTCGAGTTCGCGCCTAAGGGCGTACGGGTCAACGGCATCCTCATCGGCCTGGTCGAGTCCGGCCAGTG GCGGCGCCGTTTCGAAGCCCGCGAAGAGCGCGAGCTGGACTGGGCGCAATGGACCGCGCAGCTGGCGCGGAACAAGCAGATTCCCCTGGGACGCCTGGGC AAGCCGATCGAGGCGGCCCGCGCCATCCTGTTCCTCGCATCTCCCCTGTCTGCCTATACGACGGGCAGTCATATCGACGTTTCCGGAGGGTTGTCCCGTC

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Need more than 500 BP? Try our sequence retrieval tool or view intergenic regions in GBrowse.

DNA Sequence ATGCGTAACGCAAGCCAAGTCACCGTCGGCGCCGCCATCGCCGCCTTCCTCGAACAGTGCGAGGTGAAGGCCGCCTTCGGGGTGATCTCGATCCACAACA TGCCGATCCTCGATGCCTTCGCCAGCCGCGGCAACATCCGTTTCGTGATGGCCCGCGGCGAGGCCGGGGCGGCCAACATGGCCGATGCCTACGCCCGCAC CAGCGGTGGCCTGGGCGTGTGCCTGACCAGCACCGGAACCGCCGCCGGCAACGCTGCCGGGGCGCTGGTCGAGGCGCTCACTGCCGGCACCCCGCTGCTG CACCTGACCGGGCAGATCGAAACCCCCTACCTGGATCGGAGCCTCGCCTACATCCACGAGGCGCCGGACCAGTTGAGCATGCTCAAGGCCATCTCCAAGG CGGCCTTCCGCGTGCGCAGCGTCGACACCGCCATCAGCACCCTCAAGCTGGCCGTGCAAACCGCCCTGACCGCGCCCGCCGGCCCGGTGAGCGTGGAAAT CCCGATCGATATCCAGTCGGCGCTGATCAACCTGCCGGCCGACCTGTCGCCGCTGCCGGTGCCGGTGGCCAGGCCCTCCGAGCAAGCCTTGGACGACCTA GCCGAGCGTTTCGCCCAGGCGCGGCGACCGATGCTCTGGCTGGGGGGCGGTGCCCGGCATGCCGGCCCGCAGGTACAACGCCTGCTGGCCATGGGCGTGG GCGTGGTCACCAGCACCCAGGGGCGTGGCATCGTCCCGGAAGACGACGCGCGTTCCCTCGGCGCCTTCAACCTGAATAAACCGGTGGAGCGGTTCTACCA GAGCTGCGACGCCATGCTCGTGGTGGGCTCGCGCCTGCGCGGCAACGAAACCCTCAAGTACGAACTCAAGCTCCCGCGTCCGCTTTACCGGGCAGACGCC GATGCCACGGCGGAGGGCCGCTGCTACCCCAGCGATTTCTTCGTCTGCGGCGATTCCGAACGGGTCCTCAAGGGGCTCGCCGACCGCCTGGAAGGGCGCC TGTCGGTGGACCCGGCCTTCGCCGCGGATCTCGCCGCCGCGCGCAACCAGGCCCGCGCCCAGTTGGTGGACGGCCTTGGCCCCTACGCTTCGCTGGTGGA GCAACTGCAGGCGCTGGCCGGCCGCAATTTCAACTGGGTGCGCGACGTCACCGTCTCCAACAGCACCTGGGGCAACCGCCACCTGAATATCTTCAGCCCC CGCGCCGGCGTCCACGCCCTCGGCGGTGGCATCGGCCAGGGCCTGGCCATGGGCATCGGCGCGGCGGTCGGCGCGGCGGAAACCGCGCCTGGGCGCAAGA CCTTCGTGCTCGCCGGCGACGGCGGCTTCATCCTCAACCTGGGCGAACTGGCCACCGCCGTGCAGGAGCGGGCCGACATGCTCATCGTGCTGATGAACGA CCAGGGCTACGGGGTGATCAAGAACATCCAGGACGCCGCCTACGGTGGCCGCCGCTGCTACGTCGACCTGCACACCCCGGACTATGCCCAACTGTCGGCT TCCCTCGGCCTGCGTCATGCCAAGGTCAGCGATCTGAAGGATTTCAGCGCCGTGCTCGATGGCGCCCTGGCCGAGCCAGGTCCCTTCCTGCTGGAGGTGG ACATGCTCGCGGTGGGCAGCTTCAAGAGCATTTTCGCCGGCCCGCCGACCAACGATGCCAAGACCGACAAGGCCACCGCTTGA

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Downstream 500 BP region Click here to view the nucleotide sequence of the region 500 BP downstream of this gene.
Protein Sequence MRNASQVTVGAAIAAFLEQCEVKAAFGVISIHNMPILDAFASRGNIRFVMARGEAGAANMADAYARTSGGLGVCLTSTGTAAGNAAGALVEALTAGTPLL HLTGQIETPYLDRSLAYIHEAPDQLSMLKAISKAAFRVRSVDTAISTLKLAVQTALTAPAGPVSVEIPIDIQSALINLPADLSPLPVPVARPSEQALDDL AERFAQARRPMLWLGGGARHAGPQVQRLLAMGVGVVTSTQGRGIVPEDDARSLGAFNLNKPVERFYQSCDAMLVVGSRLRGNETLKYELKLPRPLYRADA DATAEGRCYPSDFFVCGDSERVLKGLADRLEGRLSVDPAFAADLAAARNQARAQLVDGLGPYASLVEQLQALAGRNFNWVRDVTVSNSTWGNRHLNIFSP RAGVHALGGGIGQGLAMGIGAAVGAAETAPGRKTFVLAGDGGFILNLGELATAVQERADMLIVLMNDQGYGVIKNIQDAAYGGRRCYVDLHTPDYAQLSA SLGLRHAKVSDLKDFSAVLDGALAEPGPFLLEVDMLAVGSFKSIFAGPPTNDAKTDKATA

BLAST search against this genome or other genomes in database
View precomputed BLAST results against all genomes at NCBI BLINK
Operons/Regulons
Type operon
Genes
GeneProduct
PA3504 probable aldehyde dehydrogenase
PA3505 hypothetical protein
PA3506 probable decarboxylase
PA3507 probable short-chain dehydrogenase
PA3508 probable transcriptional regulator
PA3509 probable hydrolase
PA3510 hypothetical protein
PA3511 probable short-chain dehydrogenase
PA3512 probable permease of ABC transporter
PA3513 hypothetical protein
PA3514 probable ATP-binding component of ABC transporter
Evidence Computationally Predicted
PubMed 18988623
Cross-Reference DOOR-13822
PubMed  


We thank Cystic Fibrosis Foundation Therapeutics, Inc. for critical funding support for the Pseudomonas Genome Database. When acknowledging use of the database, please cite the article by Winsor et al. (2009; PMID:18978025) and not the web site URL. Thank you!

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