contact us| site map | view my clipboard
Add this annotation to your clipboard
               PA4919               
Key to diagram


View in GBrowse: (?) 16 putative orthologs View metabolic pathways using PseudoCyc Acknowledgements for this annotation
Gene Information
Strain Pseudomonas aeruginosa PAO1 (Tax ID: 208964) Replicon Chromosome(5651 genes, 6264404 bp) [ RefSeq ]
Gene name pncB1  Alternate Gene Names
Locus tag PA4919 (View 7 updates) GenBank Identifier (GI) 15600112 (Precomputed BLAST results at BLINK )
Genomic location 5518483 - 5519682 (+) Feature type CDS 
Transposon Mutant Available?Transposon mutant library help Yes (View in GBrowse) Pseudomonas Ortholog Group Explanation of Orthologous Groups
Product Information
Product Name nicotinate phosphoribosyltransferase (Class 2  Explanation of Product Name Confidence)
Alternate Product Names
Subcellular localization
Cytoplasmic (Class 3Explanation of Localization Confidence)
Function Classification / Gene Ontology (GO)
PseudoCAP Function Class Biosynthesis of cofactors, prosthetic groups and carriers
GO Accession GO Term Evidence
Molecular Function
GO:0004516 nicotinate phosphoribosyltransferase activity IEA
Biological Process
GO:0051188 cofactor biosynthetic process ISS
GO:0019358 nicotinate nucleotide salvage IEA
Cellular Component
COG PredictionExplanation of COG predictions
Accession Description Category
COG1488 PncB, Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]. Coenzyme metabolism
TIGRFAM predictionExplanation of TIGRFAM predictions
Accession Name Function Significance Role Sub Role Release No.
TIGR01514 NAPRTase nicotinate phosphoribosyltransferase 9.8e-206 Biosynthesis of cofactors, prosthetic groups, and carriers Pyridine nucleotides 8.0
Pathways
Pathways Explanation of Pathways Field
Name Database Xref
Nicotinate and nicotinamide metabolism PseudoCAP
pyridine nucleotide cycling PseudoCyc PYRNUCYC-PWY
Nicotinate and nicotinamide metabolism KEGG pae00760 Computationally Generated
Metabolic pathways KEGG pae01100 Computationally Generated
Reactions
EC Number 2.4.2.11
Homology
BLINK Precomputed BLAST results at BLINK
Homologs Explanation of Homologs Field 69% similar to pncB gene product of Salmonella typhimurium
Structure Features
PFAM predictions Explanation of PFAM predictions
Accession Domain Start Stop E-value Release No.
PF04095 NAPRTase, Nicotinate phosphoribosyltransferase (NAPRTase) family. 171 398 8e-86 23.0
 
Operons/Regulons
Type operon
Genes
GeneProduct
PA4918 hypothetical protein
pncB1 nicotinate phosphoribosyltransferase
nadE NH3-dependent NAD synthetase
Evidence Computationally Predicted
PubMed 18988623
Cross-Reference DOOR-14115
Microarray Expression Data
NCBI GEO Link
Sequence data
Upstream 500 BP Region CACAGCCCGAAGGCTGCCTGGGTAGTGGAAAGCGCCGAGCAGATGCTGCGGCCGCTGGCCTATCCGGATGCCGACCTGACCTGGGTGAGCCACTGCGTAC CGGGTACGCCGGGTTTCGAGCTGCTCGACGAACTGCCGCGGCCGATCGACTACGACTTCTTCGTCTGGAAGGGCGTGGAGCCGGACCTGCATCCCTACGG CGCCTGCTACCACGATCTGGCGGAACGCCGCAGCACCGGGGTCATCGAATACCTGAGGCAGAATGGCGTGAGCCATGTGCTGGTGGGTGGCCTGGCGCTG GACTACTGCGTGAAGAACACCGCCCTGCAACTGCGCCGCGCCGGTTTCGAGGTGCTGCTCTACCTGCCCGCCTGCCGGGCCATCGCCGAGGACACCGCGC AGCGGGCCTGCGACGAGATGCGCGACGCCGGGGTGATCCTCTGCGCCGACCTGGAACGACTGGATAGCGCCCTCGCCGGCGCCGACAAGGAGAAGTGAAC

BLAST search against this genome or other genomes in database
Need more than 500 BP? Try our sequence retrieval tool or view intergenic regions in GBrowse.

DNA Sequence ATGGCCGAAAGCGTCTTTGCCGAGCGCATTGTGCAGAACCTGCTCGATACCGATTTCTACAAGCTGACCATGATGCAGGCGGTGCTGCACAACTACCCCA ACGCCGAAGTGGAGTGGGAATTCCGCTGCCGCAACGCCGAGGACCTGCGTCCGTACCTGGCGGAGATCCGCTACCAGATCGAGCGCCTCGCCGAAGTCGA GGTAACCGCCGACCAGCTCGCCTTCCTCGAACGCATCCCGTTCATGAAGCCGGACTTCATCCGCTTCCTCAGCCTGTTCCGCTTCAACCTGCGCTACGTG CACACCGGCATCGAGGATGGCCAACTGGCAATCCGCCTGCGCGGCCCATGGCTGCACGTGATCCTCTTCGAGGTGCCGCTGCTGGCCATCGTCAGCGAGG TGCGCAACCGTTATCGCTACCGCGAGGTGGTCCTGGAACAGGTCGGCGAGCAGCTCTATCGCAAGCTCGACTGGCTCTCCGCCCAGGCCAGCAGCGAGGA ACTCGCGGAATTCCAGGTCGCCGACTTCGGCACCCGCCGGCGCTTCTCCTACCGCACCCAGGAGGAAGTGGTGCATATCCTCAAGCGCGACTTCCCCGGG CGCTTCGTCGGCACCAGCAACGTGCACCTGGCCCGCGAGTACGACCTCAAGCCGATCGGCACCATGGCCCACGAATGGCTGATGGCCCACCAGCAACTCG GCCCGCGGCTGGTCGACAGCCAGCAAGCGGCGCTGGACTGCTGGGTCCGCGAGTACCGCGGACAGCTCGGCATAGCCCTGACCGACTGCATTACCATGGA TGCCTTCCTCGACGACTTCGACCTGTACTTCGCCAAGCTCTTCGACGGCCTGCGCCACGATTCGGGCGACCCGCTGGCCTGGGCGGAGAAAGCCATCGCC CACTACCGCCGCCTGGGTATCGACCCGCTGAGCAAGACCCTGGTGTTCTCCGACGGGCTGGACATGCCCAAGGCGTTGCAGCTGTTCCGCGCGCTACGTG GCAAGATCAACGTCAGCTTCGGCATCGGCACCAACCTGACCTGCGACATCCCGGGGGTCGAGCCGATGAACATCGTCCTGAAGATGACGGCCTGCAACGG CCATCCGGTGGCGAAGATATCCGACGCCCCGGGCAAGACCCAATGCCGCGACGAGAACTTCGTCGCCTACCTCCGCCACGTCTTCAACGTGCCGGCCTAA

BLAST search against this genome or other genomes in database


Downstream 500 BP region Click here to view the nucleotide sequence of the region 500 BP downstream of this gene.

Protein Sequence MAESVFAERIVQNLLDTDFYKLTMMQAVLHNYPNAEVEWEFRCRNAEDLRPYLAEIRYQIERLAEVEVTADQLAFLERIPFMKPDFIRFLSLFRFNLRYV HTGIEDGQLAIRLRGPWLHVILFEVPLLAIVSEVRNRYRYREVVLEQVGEQLYRKLDWLSAQASSEELAEFQVADFGTRRRFSYRTQEEVVHILKRDFPG RFVGTSNVHLAREYDLKPIGTMAHEWLMAHQQLGPRLVDSQQAALDCWVREYRGQLGIALTDCITMDAFLDDFDLYFAKLFDGLRHDSGDPLAWAEKAIA HYRRLGIDPLSKTLVFSDGLDMPKALQLFRALRGKINVSFGIGTNLTCDIPGVEPMNIVLKMTACNGHPVAKISDAPGKTQCRDENFVAYLRHVFNVPA

BLAST search against this genome or other genomes in database
View precomputed BLAST results against all genomes at NCBI BLINK
References
PubMed Variation of cofactor levels in Escherichia coli. Sequence analysis and expression of the pncB gene encoding nicotinic acid phosphoribosyltransferase.
Wubbolts MG, Terpstra P, van Beilen JB, Kingma J, Meesters HA, Witholt B.
J Biol Chem. 1990 Oct 15;265(29):17665-72.
PMID: 2211655
The complete genome sequence of Escherichia coli K-12.
Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y.
Science. 1997 Sep 5;277(5331):1453-62.
PMID: 9278503
 
Alternate Annotations and Cross-References
TIGR NTL03PA04920
Systomonas PA4919
RefSeq NP_253606.1
GI 15600112
KEGG PA4919
GBrowse Click here for a GBrowse View of this and other annotations.
PseudoCyc Click here to view metabolic pathways in PseudoCyc.


We thank Cystic Fibrosis Foundation Therapeutics, Inc. for critical funding support for the Pseudomonas Genome Database. When acknowledging use of the database, please cite the article by Winsor et al. (2009; PMID:18978025) and not the web site URL. Thank you!

| What's New | FAQs | Cystic Fibrosis | Pseudomonas aeruginosa | Who is Involved? | Annotation Approach | Get Involved | Supplemental Data | Links to More Analyses | Site Map | Acknowledgements | Contact Us |