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               PA5372               
Key to diagram


View in GBrowse: (?) 16 putative orthologs View metabolic pathways using PseudoCyc Acknowledgements for this annotation
Gene Information
Strain Pseudomonas aeruginosa PAO1 (Tax ID: 208964) Replicon Chromosome(5651 genes, 6264404 bp) [ RefSeq ]
Gene name betA  Alternate Gene Names
Locus tag PA5372 (View 7 updates) GenBank Identifier (GI) 15600565 (Precomputed BLAST results at BLINK )
Genomic location 6049049 - 6047364 (-) Feature type CDS 
Transposon Mutant Available?Transposon mutant library help Yes (View in GBrowse) Pseudomonas Ortholog Group Explanation of Orthologous Groups
Product Information
Product Name choline dehydrogenase (Class 2  Explanation of Product Name Confidence)
Alternate Product Names betA protein
Subcellular localization
Function Classification / Gene Ontology (GO)
PseudoCAP Function Class Amino acid biosynthesis and metabolism
Adaptation, Protection
GO Accession GO Term Evidence
Molecular Function
GO:0008812 choline dehydrogenase activity IEA
Biological Process
GO:0006520 amino acid metabolic process ISS
GO:0050896 response to stimulus ISS
GO:0006113 fermentation RCA
GO:0019285 glycine betaine biosynthetic process from choline IEA
Cellular Component
COG PredictionExplanation of COG predictions
Accession Description Category
COG2303 BetA, Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]. Amino acid transport and metabolism
TIGRFAM predictionExplanation of TIGRFAM predictions
Accession Name Function Significance Role Sub Role Release No.
TIGR01810 betA choline dehydrogenase 0 Cellular processes Adaptations to atypical conditions 8.0
Pathways
Pathways Explanation of Pathways Field
Name Database Xref
Glycine, serine and threonine metabolism PseudoCAP
betaine biosynthesis III PseudoCyc P542-PWY
Glycine, serine and threonine metabolism KEGG pae00260 Computationally Generated
Reactions
EC Number 1.1.99.1
Homology
BLINK Precomputed BLAST results at BLINK
Homologs Explanation of Homologs Field 88% similar to E. coli betA gene product
Most Similar Human Homolog
ENSP00000319851, Percent Identity: 49.72%, E-Value: 2e-140, Ensembl Release: 56.
Description: Choline dehydrogenase, mitochondrial Precursor
Structure Features
Structure Features Explanation of Structure Features Field GMC oxidoreductase signature Prosite: PDOC00543
PFAM predictions Explanation of PFAM predictions
Accession Domain Start Stop E-value Release No.
PF00732 GMC_oxred_N, GMC oxidoreductase. 75 303 2e-52 23.0
PF05199 GMC_oxred_C, GMC oxidoreductase. 393 529 3e-51 23.0
 
Genomic Context
Genomic context Explanation of Genomic Context Field - Adjacent to betI and betB genes, like E. coli
Operons/Regulons
Type operon
Genes
GeneProduct
betA choline dehydrogenase
betB betaine aldehyde dehydrogenase
Evidence Computationally Predicted
PubMed 18988623
Cross-Reference DOOR-14222
Microarray Expression Data
NCBI GEO Link
Sequence data
Upstream 500 BP Region CGCCGACCGTGTTCACCGATTGCCGCGACGACATGACCATCGTCCGCGAGGAAATCTTCGGCCCGGTGATGAGCATCCTGGTCTATGACGACGAAGACGA GGCGATCCGCCGCGCCAACGATACCGAGTACGGCCTCGCCGCCGGCGTCGTGACCCAGGACCTGGCCCGCGCCCACCGCGCCATCCATCGCCTGGAAGCC GGCATCTGCTGGATCAATACCTGGGGCGAGTCGCCGGCGGAAATGCCGGTCGGCGGTTACAAGCAATCCGGTGTCGGTCGCGAGAACGGTCTCACCACCC TGGCTCATTACACTCGCATCAAGTCCGTGCAAGTGGAGCTGGGCGACTACGCCTCGGTGTTCTGAGCCTCGACGCAGCGCTCGAACCCCTAACCAGGCCG GTCCCAGGCAACGCTCCCTGACACCGGCCATTCCGAACTTCCAGACACCGGCGCGCCAGCGTCGCGGCCGGTGTCATGCCGAGAAAAGAGGAAGGCCTGC

BLAST search against this genome or other genomes in database
Need more than 500 BP? Try our sequence retrieval tool or view intergenic regions in GBrowse.

DNA Sequence ATGTCCCAGGAATTCGACTACATCATCATCGGAGCCGGCTCTGCCGGTAACGTACTCGCTACCCGCCTCACCGAAGATGCCGACGTCAGCGTCCTGCTGC TCGAAGCCGGCGGTCCCGACTACCGCTTCGACTTCCGCACCCAGATGCCGGCGGCCCTTGCCTTCCCGCTGCAGGGGCGGCGCTACAACTGGGCCTACGA GACCGACCCCGAGCCCTACATGAACAACCGCCGCATGGAGTGCGGTCGCGGCAAGGGCCTGGGCGGCTCCTCGCTGATCAACGGCATGTGCTACATCCGC GGCAACGCCCTGGACTTCGACGGCTGGGCCAAGGAGCCGGGCCTCGAGGACTGGAGCTACCTCGACTGCCTGCCGTACTTCCGCAAGGCGGAAACCCGGG ACATCGGCCCCAACGACTACCATGGCGGCGACGGCCCGGTCAGCGTGACCACGCCGAAGGCCGGCAACAACCCACTGTTCCATGCGATGGTCGAGGCCGG CGTGCAGGCCGGCTACCCGCGAACCGATGACCTCAACGGCTACCAGCAGGAAGGCTTCGGCCCCATGGACCGGACCGTCACCCCGGAGGGCCGTCGCGCC GCCACCGGGCGCGGCTACCTGGACCAGGCCCGCGGCCGGCCCAACCTGACCATCGTCACCCACGCCCTGAGCGACCGCATCCTGTTCAGCGGCAAGCGCG CCATCGGCGTCTCCTACCTGGTGGGCAACGGCGACAACCCGGTCACCGCCCACGCCCGCCGCGAAGTATTGGTGTGCAGCGGCGCGATCGCCTCGCCGCA ATTGCTGCAACGCTCCGGCGTCGGCCCGGCGGCCCTGCTGCGCGACCTGGACATCCCGGTGGTGCATGACCTGCCGGGCGTCGGCGCCAACCTGCAGGAT CACCTGGAACTCTACCTGCAGTACGCCTGCAAGCAGCCGGTGTCGATCTACCCGGCGACCAAATGGTGGAACCAGCCTGCCATCGGTGCCCAGTGGCTGT TCCTCGGCAAGGGCCTCGGCGCCAGCAACCAGTTCGAGGCCGGCGGCTTCATCCGAACCCGCGAAGCGTTCGAATGGCCGAACATCCAGTTCCATTTCCT CCCGGTGGCGATCAACTACAACGGCAGCAAGGGCGTGCAGGAGCACGGCTTCCAGGCGCACATGGGCTCGATGCGCTCGCCGAGCCGCGGGCGCATCCAC CTGAAGTCCAGGGACCCGCGCCAGCATCCGAGCATCCTGTTCAACTACATGTCCCACGAGCAGGACTGGCAGGAGTTCCGCGACGGCATCCGGCTGACCC GCGAGATCATGAACCAGCCGGCGCTGGACCCCTATCGGGGCCGCGAGTTGAGCCCTGGGGTGAGCGTGCAGTCGGACGCCGAACTCGACGAGTTCATCCG CAACCATGCTGAGACCGCTTTCCACCCATCCTGCTCGTGCAAGATGGGCAGCGACGACATGGCGGTGGTCGATGGCCAGGGACGGGTCCATGGCATGGAA GGACTGCGAGTGGTGGATGCGTCGATCATGCCGCTGATCATCACCGGCAACCTCAATGCCACCACCATCATGATGGCCGAGAAGATCGCCGACAGGATCC GCGGTCGCCAGCCGCTGCCGCGCAGCACGGCGAAGTACTACGTGGCCGGGGATGCGCCGGTACGCGGCAACCCCGTGCGGGCCTGA

BLAST search against this genome or other genomes in database


Downstream 500 BP region Click here to view the nucleotide sequence of the region 500 BP downstream of this gene.

Protein Sequence MSQEFDYIIIGAGSAGNVLATRLTEDADVSVLLLEAGGPDYRFDFRTQMPAALAFPLQGRRYNWAYETDPEPYMNNRRMECGRGKGLGGSSLINGMCYIR GNALDFDGWAKEPGLEDWSYLDCLPYFRKAETRDIGPNDYHGGDGPVSVTTPKAGNNPLFHAMVEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPEGRRA ATGRGYLDQARGRPNLTIVTHALSDRILFSGKRAIGVSYLVGNGDNPVTAHARREVLVCSGAIASPQLLQRSGVGPAALLRDLDIPVVHDLPGVGANLQD HLELYLQYACKQPVSIYPATKWWNQPAIGAQWLFLGKGLGASNQFEAGGFIRTREAFEWPNIQFHFLPVAINYNGSKGVQEHGFQAHMGSMRSPSRGRIH LKSRDPRQHPSILFNYMSHEQDWQEFRDGIRLTREIMNQPALDPYRGRELSPGVSVQSDAELDEFIRNHAETAFHPSCSCKMGSDDMAVVDGQGRVHGME GLRVVDASIMPLIITGNLNATTIMMAEKIADRIRGRQPLPRSTAKYYVAGDAPVRGNPVRA

BLAST search against this genome or other genomes in database
View precomputed BLAST results against all genomes at NCBI BLINK
References
PubMed Characterization of an Escherichia coli gene encoding betaine aldehyde dehydrogenase (BADH): structural similarity to mammalian ALDHs and a plant BADH.
Boyd LA, Adam L, Pelcher LE, McHughen A, Hirji R, Selvaraj G.
Gene. 1991 Jul 15;103(1):45-52.
PMID: 1879697
DNA sequence and analysis of the bet genes encoding the osmoregulatory choline-glycine betaine pathway of Escherichia coli.
Lamark T, Kaasen I, Eshoo MW, Falkenberg P, McDougall J, Strom AR.
Mol Microbiol. 1991 May;5(5):1049-64.
PMID: 1956285
 
Alternate Annotations and Cross-References
TIGR NTL03PA05373
Systomonas PA5372
RefSeq NP_254059.1
GI 15600565
KEGG PA5372
GBrowse Click here for a GBrowse View of this and other annotations.
PseudoCyc Click here to view metabolic pathways in PseudoCyc.


We thank Cystic Fibrosis Foundation Therapeutics, Inc. for critical funding support for the Pseudomonas Genome Database. When acknowledging use of the database, please cite the article by Winsor et al. (2009; PMID:18978025) and not the web site URL. Thank you!

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