Pseudomonas aeruginosa PAO1, PA0430 (metF)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02219
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Cellular Component GO:0005829 cytosol
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00676
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0009086 methionine biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00676
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006555 methionine metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02219
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Central intermediary metabolism Other PAO1 genes in this class
Amino acid biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae00670 One carbon pool by folate 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01120 Microbial metabolism in diverse environments 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01200 Carbon metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Methionine metabolism ECO:0000037
not_recorded
PseudoCAP Methane metabolism ECO:0000037
not_recorded
PseudoCAP One carbon pool by folate ECO:0000037
not_recorded

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Gene3D G3DSA:3.20.20.220 - - - 5 289 2.2E-92
Pfam PF02219 Methylenetetrahydrofolate reductase IPR003171 Methylenetetrahydrofolate reductase-like 10 286 2.3E-88
SUPERFAMILY SSF51730 FAD-linked oxidoreductase IPR029041 FAD-linked oxidoreductase-like 8 288 1.16E-95
PANTHER PTHR45754 METHYLENETETRAHYDROFOLATE REDUCTASE - - 9 288 1.2E-81
NCBIfam TIGR00676 JCVI: methylenetetrahydrofolate reductase [NAD(P)H] IPR004620 5,10-methylenetetrahydrofolate reductase 16 287 6.1E-100
FunFam G3DSA:3.20.20.220:FF:000014 Methylenetetrahydrofolate reductase - - 9 289 0.0
CDD cd00537 MTHFR IPR003171 Methylenetetrahydrofolate reductase-like 16 286 1.00627E-125

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.