Pseudomonas aeruginosa PAO1, PA1796 (folD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0051188 obsolete cofactor biosynthetic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Molecular Function GO:0019238 cyclohydrolase activity
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 1748668 Reviewed by curator
Biological Process GO:0009117 nucleotide metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Molecular Function GO:0003959 NADPH dehydrogenase activity
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 1748668 Reviewed by curator
Molecular Function GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02882
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Nucleotide biosynthesis and metabolism Other PAO1 genes in this class
Biosynthesis of cofactors, prosthetic groups and carriers Other PAO1 genes in this class
Translation, post-translational modification, degradation Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01120 Microbial metabolism in diverse environments 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc 1CMET2-PWY N<sup>10</sup>-formyl-tetrahydrofolate biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc CODH-PWY reductive acetyl coenzyme A pathway 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCAP One carbon pool by folate ECO:0000037
not_recorded
KEGG pae00670 One carbon pool by folate 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01200 Carbon metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Glyoxylate and dicarboxylate metabolism ECO:0000037
not_recorded

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase 239 255 7.5E-84
PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase 34 56 7.5E-84
Pfam PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain IPR020631 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 124 281 6.9E-67
PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase 256 274 7.5E-84
SUPERFAMILY SSF53223 Aminoacid dehydrogenase-like, N-terminal domain IPR046346 Aminoacid dehydrogenase-like, N-terminal domain superfamily 1 122 4.7E-41
PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase 75 102 7.5E-84
Gene3D G3DSA:3.40.50.10860 Leucine Dehydrogenase, chain A, domain 1 - - 8 277 3.7E-113
CDD cd01080 NAD_bind_m-THF_DH_Cyclohyd IPR020631 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 116 280 2.37509E-92
PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase 110 131 7.5E-84
PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase 155 175 7.5E-84
PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase 204 233 7.5E-84
Gene3D G3DSA:3.40.50.720 - - - 6 259 3.7E-113
PANTHER PTHR48099 C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED - - 1 282 1.2E-97
FunFam G3DSA:3.40.50.10860:FF:000001 Bifunctional protein FolD - - 8 153 9.6E-50
Hamap MF_01576 Bifunctional protein FolD [folD]. IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase 3 283 38.159496
SUPERFAMILY SSF51735 NAD(P)-binding Rossmann-fold domains IPR036291 NAD(P)-binding domain superfamily 123 283 7.77E-51
Pfam PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain IPR020630 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 6 121 2.6E-40
FunFam G3DSA:3.40.50.720:FF:000006 Bifunctional protein FolD - - 138 259 1.2E-49

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.