Pseudomonas aeruginosa PAO1, PA3724 (lasB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0071978 bacterial-type flagellum-dependent swarming motility
IMP
Inferred from Mutant Phenotype 		ECO:0000016
loss-of-function mutant phenotype evidence		 18245294 Reviewed by curator
Biological Process GO:0060309 elastin catabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 2842313 Reviewed by curator
Biological Process GO:0043952 protein transport by the Sec complex
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 9642203 Reviewed by curator
Biological Process GO:0015628 protein secretion by the type II secretion system
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 9642203 Reviewed by curator
Biological Process GO:0052051 obsolete interaction with host via protein secreted by type II secretion system
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 15123664 Reviewed by curator
Biological Process GO:0044010 single-species biofilm formation
IMP
Inferred from Mutant Phenotype 		ECO:0000315
mutant phenotype evidence used in manual assertion		 18245294 Reviewed by curator
Biological Process GO:0044267 cellular protein metabolic process
IDA
Inferred from Direct Assay 		ECO:0000002
direct assay evidence
Biological Process GO:0044010 single-species biofilm formation
IMP
Inferred from Mutant Phenotype 		ECO:0000016
loss-of-function mutant phenotype evidence		 18245294 Reviewed by curator
Biological Process GO:0006508 proteolysis
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 1597429 Reviewed by curator
Biological Process GO:0060309 elastin catabolic process
IGI
Inferred from Genetic Interaction 		ECO:0000316
genetic interaction evidence used in manual assertion		 1902216 Reviewed by curator
Biological Process GO:0051542 elastin biosynthetic process
IGI
Inferred from Genetic Interaction 		ECO:0000316
genetic interaction evidence used in manual assertion		 1902216 Reviewed by curator
Biological Process GO:0071978 bacterial-type flagellum-dependent swarming motility
IMP
Inferred from Mutant Phenotype 		ECO:0000315
mutant phenotype evidence used in manual assertion		 18245294 Reviewed by curator
Biological Process GO:0006508 proteolysis
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PR00730
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004222 metalloendopeptidase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PR00730
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Translation, post-translational modification, degradation Other PAO1 genes in this class
Secreted Factors (toxins, enzymes, alginate) Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae02024 Quorum sensing 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Xcp type II secretion system ECO:0000037
not_recorded
KEGG pae01503 Cationic antimicrobial peptide (CAMP) resistance 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
SUPERFAMILY SSF55486 Metalloproteases ("zincins"), catalytic domain - - 199 494 1.41E-88
Gene3D G3DSA:3.10.170.10 - - - 198 349 1.8E-56
Pfam PF03413 Peptidase propeptide and YPEB domain IPR025711 PepSY domain 123 192 8.8E-9
PRINTS PR00730 Thermolysin metalloprotease (M4) family signature IPR023612 Peptidase M4 336 352 5.8E-26
PRINTS PR00730 Thermolysin metalloprotease (M4) family signature IPR023612 Peptidase M4 419 435 5.8E-26
Pfam PF07504 Fungalysin/Thermolysin Propeptide Motif IPR011096 FTP domain 56 90 3.0E-6
PRINTS PR00730 Thermolysin metalloprotease (M4) family signature IPR023612 Peptidase M4 357 368 5.8E-26
FunFam G3DSA:3.10.170.10:FF:000002 Elastase - - 198 349 9.9E-98
Gene3D G3DSA:3.10.450.40 - - - 118 197 4.2E-22
Gene3D G3DSA:3.10.450.490 - - - 30 115 1.1E-11
Gene3D G3DSA:1.10.390.10 Neutral Protease Domain 2 IPR027268 Peptidase M4/M1, CTD superfamily 350 497 3.5E-49
Pfam PF01447 Thermolysin metallopeptidase, catalytic domain IPR013856 Peptidase M4 domain 208 345 3.4E-33
CDD cd09597 M4_TLP - - 234 492 8.53745E-101
Pfam PF02868 Thermolysin metallopeptidase, alpha-helical domain IPR001570 Peptidase M4, C-terminal 348 492 1.0E-36
PRINTS PR00730 Thermolysin metalloprotease (M4) family signature IPR023612 Peptidase M4 302 322 5.8E-26
PANTHER PTHR33794 BACILLOLYSIN - - 34 492 7.3E-104

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.