Pseudomonas aeruginosa PAO1, PA4588 (gdhA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006520 cellular amino acid metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Molecular Function GO:0004354 glutamate dehydrogenase (NADP+) activity
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 8355660 Reviewed by curator
Biological Process GO:0006520 cellular amino acid metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00208
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016491 oxidoreductase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00208
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000185
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00250 Alanine, aspartate and glutamate metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc GLUTAMOLYSIS-PWY glutamate degradation III 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCAP Glutamate metabolism ECO:0000037
not_recorded
KEGG pae00910 Nitrogen metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00220 Arginine biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Nitrogen metabolism ECO:0000037
not_recorded

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature IPR006095 Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase 191 213 6.6E-33
PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature IPR006095 Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase 112 126 6.6E-33
Gene3D G3DSA:3.40.50.720 - - - 207 371 0.0
SMART SM00839 ELFV_dehydrog_3 IPR006096 Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, C-terminal 202 443 1.4E-91
FunFam G3DSA:3.40.50.10860:FF:000002 Glutamate dehydrogenase - - 53 188 1.3E-76
FunFam G3DSA:1.10.285.10:FF:000001 Glutamate dehydrogenase - - 377 445 9.3E-31
PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature IPR006095 Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase 233 253 6.6E-33
Pfam PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain IPR006097 Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, dimerisation domain 55 182 3.0E-49
PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature IPR006095 Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase 370 381 6.6E-33
Pfam PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase IPR006096 Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, C-terminal 200 443 5.7E-86
Gene3D G3DSA:1.10.285.10 Glutamate Dehydrogenase, chain A, domain 3 - - 8 379 0.0
Gene3D G3DSA:1.10.285.10 Glutamate Dehydrogenase, chain A, domain 3 - - 380 445 4.7E-24
SUPERFAMILY SSF53223 Aminoacid dehydrogenase-like, N-terminal domain IPR046346 Aminoacid dehydrogenase-like, N-terminal domain superfamily 4 194 2.81E-75
PIRSF PIRSF000185 Glu_DH IPR014362 Glutamate dehydrogenase 20 445 4.5E-119
PANTHER PTHR43571 NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED - - 2 445 0.0
SUPERFAMILY SSF51735 NAD(P)-binding Rossmann-fold domains IPR036291 NAD(P)-binding domain superfamily 200 444 8.74E-77
FunFam G3DSA:3.40.50.720:FF:000030 Glutamate dehydrogenase - - 207 372 3.4E-72
CDD cd05313 NAD_bind_2_Glu_DH IPR033922 NAD(P) binding domain of glutamate dehydrogenase 193 444 0.0
Gene3D G3DSA:3.40.50.10860 Leucine Dehydrogenase, chain A, domain 1 - - 53 188 0.0

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.