Pseudomonas aeruginosa PAO1, PA4920 (nadE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006520 cellular amino acid metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0051188 obsolete cofactor biosynthetic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Molecular Function GO:0008795 NAD+ synthase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_00193
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003952 NAD+ synthase (glutamine-hydrolyzing) activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PTHR23090
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004359 glutaminase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PTHR23090
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Cellular Component GO:0005737 cytoplasm
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PTHR23090
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0009435 NAD biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PTHR23090
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Biosynthesis of cofactors, prosthetic groups and carriers Other PAO1 genes in this class
Amino acid biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCyc PYRNUCYC-PWY pyridine nucleotide cycling 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCAP Glutamate metabolism ECO:0000037
not_recorded
PseudoCAP Nicotinate and nicotinamide metabolism ECO:0000037
not_recorded
KEGG pae00760 Nicotinate and nicotinamide metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc PYRIDNUCSYN-PWY NAD biosynthesis I (from aspartate) 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Gene3D G3DSA:3.40.50.620 HUPs IPR014729 Rossmann-like alpha/beta/alpha sandwich fold 1 275 2.6E-95
SUPERFAMILY SSF52402 Adenine nucleotide alpha hydrolases-like - - 20 272 3.45E-77
NCBIfam TIGR00552 JCVI: NAD(+) synthase IPR003694 NAD(+) synthetase 27 273 3.6E-67
PANTHER PTHR23090 NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE IPR003694 NAD(+) synthetase 23 254 6.3E-37
Pfam PF02540 NAD synthase IPR022310 NAD/GMP synthase 28 272 9.0E-65
CDD cd00553 NAD_synthase IPR003694 NAD(+) synthetase 23 269 7.56414E-88
FunFam G3DSA:3.40.50.620:FF:000253 NH(3)-dependent NAD(+) synthetase - - 1 275 0.0
Hamap MF_00193 NH(3)-dependent NAD(+) synthetase [nadE]. IPR022926 NH(3)-dependent NAD(+) synthetase 23 275 50.742916

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.