Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA5017
|
Name |
dipA
|
Replicon | chromosome |
Genomic location | 5641010 - 5643709 (+ strand) |
Transposon Mutants | 8 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 1 transposon mutants in orthologs |
Comment | Overexpression of PA5017 impairs TTSS-mediated cytotoxicity |
RefSeq | NP_253704.1 |
GI | 15600210 |
Affymetrix | PA5017_at |
Entrez | 881298 |
GenBank | AAG08402.1 |
INSDC | AAG08402.1 |
NCBI Locus Tag | PA5017 |
protein_id(GenBank) | gb|AAG08402.1|AE004914_3|gnl|PseudoCAP|PA5017 |
TIGR | NTL03PA05018 |
UniParc | UPI00000C5EC9 |
UniProtKB Acc | Q9HUF2 |
UniProtKB ID | Q9HUF2_PSEAE |
UniRef100 | UniRef100_Q9HUF2 |
UniRef50 | UniRef50_Q4KJD2 |
UniRef90 | UniRef90_V8ER08 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
DipA
|
Synonyms | |
Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
Charge (pH 7) | -16.26 |
Kyte-Doolittle Hydrophobicity Value | -0.316 |
Molecular Weight (kDa) | 101.3 |
Isoelectric Point (pI) | 6.02 |
Individual Mappings | |
Additional evidence for subcellular localization |
Source 1 | |
Database | PseudoCAP |
Category | Not available / Not known |
Evidence |
ECO:0000315
mutant phenotype evidence used in manual assertion
|
Host Organism | Mus musculus |
Notes | |
Infection model | Mouse model of acute pneumonia |
Reference | 24901523 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 493 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG004624 (522 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA5017
Search term: dipA
Search term: DipA
|
The phosphodiesterase DipA (PA5017) is essential for Pseudomonas aeruginosa biofilm dispersion.
Roy AB, Petrova OE, Sauer K
J Bacteriol 2012 Jun;194(11):2904-15
PubMed ID: 22493016
|
BdlA, DipA and induced dispersion contribute to acute virulence and chronic persistence of Pseudomonas aeruginosa.
Li Y, Petrova OE, Su S, Lau GW, Panmanee W, Na R, Hassett DJ, Davies DG, Sauer K
PLoS Pathog 2014 Jun;10(6):e1004168
PubMed ID: 24901523
|
Identification of a new gene PA5017 involved in flagella-mediated motility, chemotaxis and biofilm formation in Pseudomonas aeruginosa.
Li Y, Xia H, Bai F, Xu H, Yang L, Yao H, Zhang L, Zhang X, Bai Y, Saris PE, Tolker-Nielsen T, Qiao M
FEMS Microbiol Lett 2007 Jul;272(2):188-95
PubMed ID: 17521365
|