Pseudomonas aeruginosa PAO1, PA5338 (spoT)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0050896 response to stimulus
ISS
Inferred from Sequence or Structural Similarity
ECO:0000044
sequence similarity evidence
Biological Process GO:0009117 nucleotide metabolic process
ISS
Inferred from Sequence or Structural Similarity
ECO:0000044
sequence similarity evidence
Biological Process GO:0006163 purine nucleotide metabolic process
ISS
Inferred from Sequence or Structural Similarity
ECO:0000044
sequence similarity evidence
Molecular Function GO:0008882 [glutamate-ammonia-ligase] adenylyltransferase activity
ISS
Inferred from Sequence or Structural Similarity
ECO:0000044
sequence similarity evidence
Biological Process GO:0015969 guanosine tetraphosphate metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF04607
ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Adaptation, Protection Other PAO1 genes in this class
Nucleotide biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCyc PPGPPMET-PWY ppGpp biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion
12867747
KEGG pae00230 Purine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Purine metabolism ECO:0000037
not_recorded

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Pfam PF13291 ACT domain IPR002912 ACT domain 622 698 9.1E-16
SUPERFAMILY SSF81301 Nucleotidyltransferase IPR043519 Nucleotidyltransferase superfamily 181 392 1.36E-61
SUPERFAMILY SSF109604 HD-domain/PDEase-like - - 5 191 1.19E-70
SMART SM00471 hd_13 IPR003607 HD/PDEase domain 41 153 6.0E-8
Gene3D G3DSA:3.30.70.260 - - - 622 701 3.6E-14
Pfam PF19296 RelA/SpoT, AH and RIS domains IPR045600 RelA/SpoT, AH and RIS domains 459 548 7.2E-10
SMART SM00954 RelA_SpoT_2 IPR007685 RelA/SpoT 235 345 1.2E-64
CDD cd01668 TGS_RSH IPR033655 RelA/SpoT, TGS domain 389 447 1.07401E-30
NCBIfam TIGR00691 JCVI: RelA/SpoT family protein IPR004811 RelA/SpoT family 26 697 0.0
Gene3D G3DSA:3.10.20.30 - IPR012675 Beta-grasp domain superfamily 381 454 3.6E-30
CDD cd05399 NT_Rel-Spo_like IPR007685 RelA/SpoT 215 331 2.11873E-37
Pfam PF02824 TGS domain IPR004095 TGS 388 447 5.7E-19
FunFam G3DSA:3.30.70.260:FF:000027 (P)ppGpp synthetase II - - 622 701 7.2E-50
FunFam G3DSA:3.10.20.30:FF:000002 GTP pyrophosphokinase (RelA/SpoT) - - 380 454 3.4E-35
FunFam G3DSA:1.10.3210.10:FF:000001 GTP pyrophosphokinase RelA - - 4 191 1.0E-86
CDD cd00077 HDc IPR003607 HD/PDEase domain 43 166 7.89813E-6
PANTHER PTHR21262 GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE - - 8 698 0.0
SUPERFAMILY SSF55021 ACT-like IPR045865 ACT-like domain 624 699 1.93E-7
CDD cd04876 ACT_RelA-SpoT - - 628 698 2.1781E-18
Gene3D G3DSA:3.30.460.10 Beta Polymerase, domain 2 IPR043519 Nucleotidyltransferase superfamily 195 325 2.3E-44
Pfam PF13328 HD domain - - 26 175 1.1E-51
Pfam PF04607 Region found in RelA / SpoT proteins IPR007685 RelA/SpoT 235 345 3.5E-37
Gene3D G3DSA:1.10.3210.10 Hypothetical protein af1432 - - 3 190 8.8E-73
FunFam G3DSA:3.30.460.10:FF:000001 GTP pyrophosphokinase RelA - - 192 325 6.7E-55
SUPERFAMILY SSF81271 TGS-like IPR012676 TGS-like 375 447 1.72E-22

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.