Pseudomonas syringae pv. syringae B728a, Psyr_0033 (trpA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas syringae pv. syringae B728a (Feil et al., 2005)
GCF_000012245.1|latest
Locus Tag
Psyr_0033
Name
trpA
Replicon chromosome
Genomic location 37192 - 38001 (- strand)

Cross-References

RefSeq YP_233145.1
GI 66043304
EC Number 4.2.1.20
Entrez 3365508
INSDC AAY35107.1
NCBI Locus Tag Psyr_0033
UniParc UPI0000394EEB
UniProtKB Acc Q500R5
UniProtKB ID TRPA_PSEU2
UniRef100 UniRef100_Q500R5
UniRef50 UniRef50_P07344
UniRef90 UniRef90_Q88B60

Product

Feature Type CDS
Coding Frame 1
Product Name
tryptophan synthase subunit alpha
Synonyms
Evidence for Translation
Charge (pH 7) -7.59
Kyte-Doolittle Hydrophobicity Value 0.132
Molecular Weight (kDa) 28.4
Isoelectric Point (pI) 4.98

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
4-(2-HYDROXYPHENYLSULFINYL)-BUTYLPHOSPHONIC ACID DB07925 DrugBank 5.1.4 P00929 Tryptophan synthase alpha chain 37.3 268 1.3e-38
2-({[4-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}AMINO)ETHYL DIHYDROGEN PHOSPHATE DB07748 DrugBank 5.1.4 P00929 Tryptophan synthase alpha chain 37.3 268 1.3e-38
Indole-3-Propanol Phosphate DB03171 DrugBank 5.1.4 P00929 Tryptophan synthase alpha chain 37.3 268 1.3e-38
5-FLUOROINDOLE PROPANOL PHOSPHATE DB07773 DrugBank 5.1.4 P00929 Tryptophan synthase alpha chain 37.3 268 1.3e-38
Indole-3-Glycerol Phosphate DB04143 DrugBank 5.1.4 P00929 Tryptophan synthase alpha chain 37.3 268 1.3e-38
4-(2-HYDROXYPHENYLTHIO)-1-BUTENYLPHOSPHONIC ACID DB07890 DrugBank 5.1.4 P00929 Tryptophan synthase alpha chain 37.3 268 1.3e-38
2-{[4-(TRIFLUOROMETHOXY)BENZOYL]AMINO}ETHYL DIHYDROGEN PHOSPHATE DB07745 DrugBank 5.1.4 P00929 Tryptophan synthase alpha chain 37.3 268 1.3e-38
2-[(2-NAPHTHYLSULFONYL)AMINO]ETHYL DIHYDROGEN PHOSPHATE DB07732 DrugBank 5.1.4 P00929 Tryptophan synthase alpha chain 37.3 268 1.3e-38
N-[1H-INDOL-3-YL-ACETYL]VALINE ACID DB07953 DrugBank 5.1.4 P00929 Tryptophan synthase alpha chain 37.3 268 1.3e-38
N-[1H-INDOL-3-YL-ACETYL]ASPARTIC ACID DB07951 DrugBank 5.1.4 P00929 Tryptophan synthase alpha chain 37.3 268 1.3e-38
N-[1H-INDOL-3-YL-ACETYL]GLYCINE ACID DB07952 DrugBank 5.1.4 P00929 Tryptophan synthase alpha chain 37.3 268 1.3e-38
4-(2-HYDROXY-4-FLUOROPHENYLTHIO)-BUTYLPHOSPHONIC ACID DB07894 DrugBank 5.1.4 P00929 Tryptophan synthase alpha chain 37.3 268 1.3e-38

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 580 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000035 (538 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: Psyr_0033
Search term: trpA

Human Homologs

References

No references are associated with this feature.