Pseudomonas aeruginosa B136-33, G655_02160

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas aeruginosa B136-33
GCF_000359505.1|latest
Locus Tag
G655_02160
Name
Replicon chromosome
Genomic location 463169 - 463612 (- strand)

Cross-References

RefSeq YP_007707281.1
GI 478476630
Entrez 15133346
NCBI Locus Tag G655_02160

Product

Feature Type CDS
Coding Frame 1
Product Name
multidrug resistance operon repressor MexR
Synonyms
Evidence for Translation
Charge (pH 7) -4.65
Kyte-Doolittle Hydrophobicity Value -0.407
Molecular Weight (kDa) 17.0
Isoelectric Point (pI) 5.57

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
MexR MexR is the repressor of the MexRAB-OprM operon. Mutant forms of mexR result in up-regulation of efflux pump system MexAB-OprM. [PMID:14526032, PMID:12727072, PMID:20616806, PMID:18812515] ARO:3000506 protein overexpression model Strict 292.4 99.32 3.2.5

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4ZZL TRANSCRIPTION 04/10/15 MexR R21W derepressor mutant causing multidrug resistance in P. aeruginosa by mexAB-oprM efflux pump expression PSEUDOMONAS AERUGINOSA 2.19 X-RAY DIFFRACTION 98.5
3ECH Transcription, Transcription regulation 08/30/08 The MarR-family repressor MexR in complex with its antirepressor ArmR Pseudomonas aeruginosa 1.802 X-RAY DIFFRACTION 97.9
3MEX Transcription, Transcription Regulation 04/01/10 Crystal structure of MexR in oxidized state Pseudomonas aeruginosa 2.1 X-RAY DIFFRACTION 98.6
1LNW TRANSCRIPTION REPRESSOR 05/03/02 CRYSTAL STRUCTURE OF THE MEXR REPRESSOR OF THE MEXAB-OPRM MULTIDRUG EFFLUX OPERON OF PSEUDOMONAS AERUGINOSA Pseudomonas aeruginosa 2.1 X-RAY DIFFRACTION 99.3

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 244 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000415 (299 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: G655_02160

Human Homologs

References

No references are associated with this feature.