Pseudomonas aeruginosa B136-33, G655_02165
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa B136-33
GCF_000359505.1|latest |
| Locus Tag |
G655_02165
|
| Name |
|
| Replicon | chromosome |
| Genomic location | 463905 - 465038 (+ strand) |
Cross-References
| RefSeq | YP_007707282.1 |
| GI | 478476631 |
| Entrez | 15133347 |
| NCBI Locus Tag | G655_02165 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
RND multidrug efflux membrane fusion protein
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | 2.22 |
| Kyte-Doolittle Hydrophobicity Value | -0.215 |
| Molecular Weight (kDa) | 40.3 |
| Isoelectric Point (pI) | 8.83 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AMR gene predictions from CARD database
Identified using the Resistance Gene Identifier (RGI)
| Model Name | Definition | Accession | Model Type (?) | SNP | Cutoff | Bit Score | Percent Identity | CARD Version |
| MexA | MexA is the membrane fusion protein of the MexAB-OprM multidrug efflux complex. [PMID:15117957] | ARO:3000377 | protein homolog model | Strict | 704.5 | 100.0 | 3.2.5 |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 6TA5 | ANTIMICROBIAL PROTEIN | 10/29/19 | OprM-MexA complex from the MexAB-OprM Pseudomonas aeruginosa whole assembly reconstituted in nanodiscs | Pseudomonas aeruginosa | 3.2 | ELECTRON MICROSCOPY | 100.0 |
| 1T5E | TRANSPORT PROTEIN | 05/04/04 | The structure of MexA | Pseudomonas aeruginosa | 3 | X-RAY DIFFRACTION | 100.0 |
| 6TA6 | ANTIMICROBIAL PROTEIN | 10/29/19 | MexAB assembly of the Pseudomonas MexAB-OprM efflux pump reconstituted in nanodiscs | Pseudomonas aeruginosa | 3.2 | ELECTRON MICROSCOPY | 100.0 |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 394 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG000416 (526 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: G655_02165
Search term: RND multidrug efflux membrane fusion protein
|
Human Homologs
References
No references are associated with this feature.