Pseudomonas aeruginosa B136-33, G655_02170

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas aeruginosa B136-33
GCF_000359505.1|latest
Locus Tag
G655_02170
Name
Replicon chromosome
Genomic location 465054 - 468194 (+ strand)

Cross-References

RefSeq YP_007707283.1
GI 478476632
Entrez 15133348
NCBI Locus Tag G655_02170

Product

Feature Type CDS
Coding Frame 1
Product Name
RND multidrug efflux transporter MexB
Synonyms
Evidence for Translation
Charge (pH 7) -9.89
Kyte-Doolittle Hydrophobicity Value 0.274
Molecular Weight (kDa) 112.8
Isoelectric Point (pI) 5.40

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
MexB MexB is the inner membrane multidrug exporter of the efflux complex MexAB-OprM. [PMID:19361527, PMID:21178960, PMID:14973037, PMID:20583998] ARO:3000378 protein homolog model Strict 1984.5 99.9 3.2.5

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3W9I MEMBRANE PROTEIN 04/04/13 Structural basis for the inhibition of bacterial multidrug exporters Pseudomonas aeruginosa 2.71 X-RAY DIFFRACTION 100.0
2V50 MEMBRANE PROTEIN 10/01/08 The Missing Part of the Bacterial MexAB-OprM System: Structural determination of the Multidrug Exporter MexB PSEUDOMONAS AERUGINOSA PA01 3 X-RAY DIFFRACTION 100.0
6IOK MEMBRANE PROTEIN 10/30/18 Cryo-EM structure of multidrug efflux pump MexAB-OprM (0 degree state) Pseudomonas aeruginosa PAO1 3.64 ELECTRON MICROSCOPY 100.0
6IIA MEMBRANE PROTEIN 10/04/18 MexB in complex with LMNG Pseudomonas aeruginosa PAO1 2.91 X-RAY DIFFRACTION 100.0
3W9J MEMBRANE PROTEIN 04/04/13 Structural basis for the inhibition of bacterial multidrug exporters Pseudomonas aeruginosa 3.15 X-RAY DIFFRACTION 100.0
6IOL MEMBRANE PROTEIN 10/30/18 Cryo-EM structure of multidrug efflux pump MexAB-OprM (60 degree state) Pseudomonas aeruginosa; Pseudomonas aeruginosa PAO1 3.76 ELECTRON MICROSCOPY 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 488 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000417 (2093 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: G655_02170

Human Homologs

References

No references are associated with this feature.