Pseudomonas aeruginosa PAO1, PA0094 (eagT6)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0094
Name
eagT6
Replicon chromosome
Genomic location 114611 - 115045 (- strand)
Transposon Mutants in orthologs 1 transposon mutants in orthologs
CommentThis protein is a molecular chaperone for the adjacently encoded T6SS effector Tse6 (PA0093)

Cross-References

RefSeq NP_248784.1
GI 15595292
Affymetrix PA0094_at
DNASU PaCD00006041
Entrez 879595
GenBank AAG03484.1
INSDC AAG03484.1
NCBI Locus Tag PA0094
protein_id(GenBank) gb|AAG03484.1|AE004448_3|gnl|PseudoCAP|PA0094
TIGR NTL03PA00095
UniParc UPI00000C4F2F
UniProtKB Acc Q9I738
UniProtKB ID Q9I738_PSEAE
UniRef100 UniRef100_W0YKR3
UniRef50 UniRef50_Q4K3M6
UniRef90 UniRef90_A6UXM9

Product

Feature Type CDS
Coding Frame 1
Product Name
EagT6
Product Name Confidence: Class 1
Synonyms hypothetical protein
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -0.57
Kyte-Doolittle Hydrophobicity Value -0.464
Molecular Weight (kDa) 16.5
Isoelectric Point (pI) 6.80

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
6XRF CHAPERONE 07/12/20 EagT6 Tse6 NT complex Pseudomonas aeruginosa; Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.56 X-RAY DIFFRACTION 100.0
1TU1 STRUCTURAL GENOMICS, UNKNOWN FUNCTION 06/24/04 Crystal Structure of Protein of Unknown Function PA94 from Pseudomonas aeruginosa, Putative Regulator Pseudomonas aeruginosa 1.95 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 13 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000093 (310 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0094
Search term: eagT6
Search term: EagT6

Human Homologs

References

An interbacterial NAD(P)(+) glycohydrolase toxin requires elongation factor Tu for delivery to target cells.
Whitney JC, Quentin D, Sawai S, LeRoux M, Harding BN, Ledvina HE, Tran BQ, Robinson H, Goo YA, Goodlett DR, Raunser S, Mougous JD
Cell 2015 Oct 22;163(3):607-19
PubMed ID: 26456113