Pseudomonas aeruginosa PAO1, PA0172 (siaA)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest |
| Locus Tag |
PA0172
|
| Name |
siaA
|
| Replicon | chromosome |
| Genomic location | 194757 - 196748 (- strand) |
| Transposon Mutants | 2 transposon mutants in PAO1 |
| Transposon Mutants in orthologs | 2 transposon mutants in orthologs |
| Comment | Involved in postranscriptional regulation of CupA fimbriae via transcriptional activation of rsmZ |
| Comment | Involved in surfactant-induced (SDS) aggregation. |
Cross-References
| RefSeq | NP_248862.1 |
| GI | 15595370 |
| Affymetrix | PA0172_at |
| Entrez | 879545 |
| GenBank | AAG03562.1 |
| INSDC | AAG03562.1 |
| NCBI Locus Tag | PA0172 |
| protein_id(GenBank) | gb|AAG03562.1|AE004455_3|gnl|PseudoCAP|PA0172 |
| TIGR | NTL03PA00173 |
| UniParc | UPI00000C4F7B |
| UniProtKB Acc | Q9I6W0 |
| UniProtKB ID | Q9I6W0_PSEAE |
| UniRef100 | UniRef100_Q9I6W0 |
| UniRef50 | UniRef50_Q9I6W0 |
| UniRef90 | UniRef90_Q9I6W0 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
SiaA
|
| Synonyms | |
| Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
| Charge (pH 7) | 0.03 |
| Kyte-Doolittle Hydrophobicity Value | -0.206 |
| Molecular Weight (kDa) | 74.0 |
| Isoelectric Point (pI) | 7.00 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 6K4E | SIGNALING PROTEIN | 05/23/19 | SiaA-PP2C domain of Pseudomonas aeruginosa | PSEUDOMONAS AERUGINOSA | 2.094 | X-RAY DIFFRACTION | 100.0 |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 243 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG000170 (326 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PA0172
Search term: siaA
Search term: SiaA
|
Human Homologs
References
|
Detergent-induced cell aggregation in subpopulations of Pseudomonas aeruginosa as a preadaptive survival strategy.
Klebensberger J, Lautenschlager K, Bressler D, Wingender J, Philipp B
Environ. Microbiol. 2007 Sep;9(9):2247-59
PubMed ID: 17686022
|
|
SiaA and SiaD are essential for inducing autoaggregation as a specific response to detergent stress in Pseudomonas aeruginosa.
Klebensberger J, Birkenmaier A, Geffers R, Kjelleberg S, Philipp B
Environ. Microbiol. 2009 Dec;11(12):3073-86
PubMed ID: 19638175
|
|
SiaA/D Interconnects c-di-GMP and RsmA Signaling to Coordinate Cellular Aggregation of Pseudomonas aeruginosa in Response to Environmental Conditions.
Colley B, Dederer V, Carnell M, Kjelleberg S, Rice SA, Klebensberger J
Front Microbiol 2016 ;7
PubMed ID: 26955366
|