Pseudomonas aeruginosa PAO1, PA0195 (pntAA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0195
Name
pntAA
Replicon chromosome
Genomic location 224101 - 225217 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_248885
GI 15600764
Affymetrix PA0195_pntA_at
Entrez 878345
NCBI Locus Tag PA0195
UniProtKB Acc Q14T74
UniProtKB ID Q14T74_PSEAE

Product

Feature Type CDS
Coding Frame 1
Product Name
putative NAD(P) transhydrogenase, subunit alpha part 1
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -4.43
Kyte-Doolittle Hydrophobicity Value 0.154
Molecular Weight (kDa) 38.6
Isoelectric Point (pI) 5.93

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Cytoplasmic Membrane Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 462 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000193 (525 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0195
Search term: pntAA

Human Homologs

Ensembl 110, assembly GRCh38.p14
nicotinamide nucleotide transhydrogenase [Source:HGNC Symbol;Acc:HGNC:7863]
E-value: 1.3e-65
Percent Identity: 39.3
Ensembl 110, assembly GRCh38.p14
nicotinamide nucleotide transhydrogenase [Source:HGNC Symbol;Acc:HGNC:7863]
E-value: 1.3e-65
Percent Identity: 39.3
Ensembl 110, assembly GRCh38.p14
nicotinamide nucleotide transhydrogenase [Source:HGNC Symbol;Acc:HGNC:7863]
E-value: 1.3e-65
Percent Identity: 39.3
Ensembl 110, assembly GRCh38.p14
nicotinamide nucleotide transhydrogenase [Source:HGNC Symbol;Acc:HGNC:7863]
E-value: 1.3e-65
Percent Identity: 39.3
Ensembl 110, assembly GRCh38.p14
nicotinamide nucleotide transhydrogenase [Source:HGNC Symbol;Acc:HGNC:7863]
E-value: 1.3e-65
Percent Identity: 39.3
Ensembl 110, assembly GRCh38.p14
nicotinamide nucleotide transhydrogenase [Source:HGNC Symbol;Acc:HGNC:7863]
E-value: 1.3e-65
Percent Identity: 39.3
Ensembl 110, assembly GRCh38.p14
nicotinamide nucleotide transhydrogenase [Source:HGNC Symbol;Acc:HGNC:7863]
E-value: 1.3e-65
Percent Identity: 39.3
Ensembl 110, assembly GRCh38.p14
nicotinamide nucleotide transhydrogenase [Source:HGNC Symbol;Acc:HGNC:7863]
E-value: 1.3e-65
Percent Identity: 39.3
Ensembl 110, assembly GRCh38.p14
nicotinamide nucleotide transhydrogenase [Source:HGNC Symbol;Acc:HGNC:7863]
E-value: 1.3e-65
Percent Identity: 39.3
Ensembl 110, assembly GRCh38.p14
nicotinamide nucleotide transhydrogenase [Source:HGNC Symbol;Acc:HGNC:7863]
E-value: 1.3e-65
Percent Identity: 39.3

References

Nucleotide sequence of the pntA and pntB genes encoding the pyridine nucleotide transhydrogenase of Escherichia coli.
Clarke DM, Loo TW, Gillam S, Bragg PD
Eur J Biochem 1986 Aug 1;158(3):647-53
PubMed ID: 3525165