Pseudomonas aeruginosa PAO1, PA0437 (codA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA0437
Name
codA
Replicon chromosome
Genomic location 489387 - 490658 (- strand)
Transposon Mutants 5 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_249128.1
GI 15595634
Affymetrix PA0437_codA_at
Entrez 877586
GenBank AAG03826.1
INSDC AAG03826.1
NCBI Locus Tag PA0437
protein_id(GenBank) gb|AAG03826.1|AE004481_2|gnl|PseudoCAP|PA0437
TIGR NTL03PA00438
UniParc UPI00000C5054
UniProtKB Acc Q9I680
UniProtKB ID Q9I680_PSEAE
UniRef100 UniRef100_W0YLR4
UniRef50 UniRef50_P25524
UniRef90 UniRef90_A6UYP8

Product

Feature Type CDS
Coding Frame 1
Product Name
cytosine deaminase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected by MALDI-TOF/TOF (PMID:19333994).
Charge (pH 7) -9.19
Kyte-Doolittle Hydrophobicity Value -0.186
Molecular Weight (kDa) 47.1
Isoelectric Point (pI) 5.96

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 1
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold Protein Structure Database

Available for P. aeruginosa PAO1.

View predicted 3D structure in AlphaFold DB

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 185 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000428 (493 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0437
Search term: codA

Human Homologs

References

Characterization of the Escherichia coli codBA operon encoding cytosine permease and cytosine deaminase.
Danielsen S, Kilstrup M, Barilla K, Jochimsen B, Neuhard J
Mol Microbiol 1992 May;6(10):1335-44
PubMed ID: 1640834
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994