Pseudomonas aeruginosa PAO1, PA1024
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest |
| Locus Tag |
PA1024
|
| Name |
|
| Replicon | chromosome |
| Genomic location | 1109882 - 1110868 (+ strand) |
| Transposon Mutants | 2 transposon mutants in PAO1 |
| Transposon Mutants in orthologs | 1 transposon mutants in orthologs |
Cross-References
| RefSeq | NP_249715.1 |
| GI | 15596221 |
| Affymetrix | PA1024_at |
| Entrez | 882956 |
| GenBank | AAG04413.1 |
| INSDC | AAG04413.1 |
| NCBI Locus Tag | PA1024 |
| protein_id(GenBank) | gb|AAG04413.1|AE004534_11|gnl|PseudoCAP|PA1024 |
| TIGR | NTL03PA01025 |
| UniParc | UPI00000C520C |
| UniProtKB Acc | Q9I4V0 |
| UniProtKB ID | 2NPD_PSEAE |
| UniRef100 | UniRef100_Q9I4V0 |
| UniRef50 | UniRef50_Q9I4V0 |
| UniRef90 | UniRef90_Q9I4V0 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
NADH:quinone reductase
|
| Synonyms |
2-Nitropropane Dioxygenase (changed from hypothetical protein) 2-Nitropropane Dioxygenase |
| Evidence for Translation | |
| Charge (pH 7) | -1.46 |
| Kyte-Doolittle Hydrophobicity Value | 0.040 |
| Molecular Weight (kDa) | 34.8 |
| Isoelectric Point (pI) | 6.63 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold Protein Structure Database
Available for P. aeruginosa PAO1.
| View predicted 3D structure in AlphaFold DB |
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 2GJL | OXIDOREDUCTASE | 03/31/06 | Crystal Structure of 2-nitropropane dioxygenase | Pseudomonas aeruginosa PAO1 | 2 | X-RAY DIFFRACTION | 100.0 |
| 2GJN | OXIDOREDUCTASE | 03/31/06 | crystal structure of 2-nitropropane dioxygenase complexed with FMN and substrate | Pseudomonas aeruginosa PAO1 | 2.3 | X-RAY DIFFRACTION | 100.0 |
| 6E2A | FLAVOPROTEIN, Oxidoreductase | 07/10/18 | Crystal structure of NADH:quinone reductase PA1024 from Pseudomonas aeruginosa PAO1 in complex with NAD+ | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) | 2.2 | X-RAY DIFFRACTION | 100.0 |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 345 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG000986 (387 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PA1024
Search term: NADH:quinone reductase
|
Human Homologs
References
|
Crystal structure of 2-nitropropane dioxygenase complexed with FMN and substrate. Identification of the catalytic base.
Ha JY, Min JY, Lee SK, Kim HS, Kim DJ, Kim KH, Lee HH, Kim HK, Yoon HJ, Suh SW
J Biol Chem 2006 Jul 7;281(27):18660-7
PubMed ID: 16682407
|
|
Functional Annotation of a Presumed Nitronate Monoxygenase Reveals a New Class of NADH:Quinone Reductases.
Ball J, Salvi F, Gadda G
J. Biol. Chem. 2016 Sep;291(40):21160-21170
PubMed ID: 27502282
|