Pseudomonas aeruginosa PAO1, PA1373 (fabF2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1373
Name
fabF2
Replicon chromosome
Genomic location 1489815 - 1491083 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 3 transposon mutants in orthologs

Cross-References

RefSeq NP_250064.1
GI 15596570
Affymetrix PA1373_fabF2_at
Entrez 881126
GenBank AAG04762.1
INSDC AAG04762.1
NCBI Locus Tag PA1373
protein_id(GenBank) gb|AAG04762.1|AE004567_1|gnl|PseudoCAP|PA1373
TIGR NTL03PA01374
UniParc UPI00000C5343
UniProtKB Acc Q9I3X1
UniProtKB ID Q9I3X1_PSEAE
UniRef100 UniRef100_Q9I3X1
UniRef50 UniRef50_P56902
UniRef90 UniRef90_Q9I3X1

Product

Feature Type CDS
Coding Frame 1
Product Name
3-oxoacyl-acyl carrier protein synthase II
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -3.70
Kyte-Doolittle Hydrophobicity Value 0.098
Molecular Weight (kDa) 43.5
Isoelectric Point (pI) 6.35

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Cytoplasmic Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 572 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001303 (401 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1373
Search term: fabF2

Human Homologs

Ensembl 110, assembly GRCh38.p14
3-oxoacyl-ACP synthase, mitochondrial [Source:HGNC Symbol;Acc:HGNC:26063]
E-value: 4.5e-86
Percent Identity: 44.5

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Beta-ketoacyl-acyl carrier protein synthase II of Escherichia coli. Evidence for function in the thermal regulation of fatty acid synthesis.
Garwin JL, Klages AL, Cronan JE Jr
J Biol Chem 1980 Apr 25;255(8):3263-5
PubMed ID: 6988423
Cloning of the fabF gene in an expression vector and in vitro characterization of recombinant fabF and fabB encoded enzymes from Escherichia coli.
Edwards P, Nelsen JS, Metz JG, Dehesh K
FEBS Lett 1997 Jan 27;402(1):62-6
PubMed ID: 9013860