Pseudomonas aeruginosa PAO1, PA1623

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1623
Name
Replicon chromosome
Genomic location 1766285 - 1766947 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 3 transposon mutants in orthologs

Cross-References

RefSeq NP_250314.1
GI 15596820
Affymetrix PA1623_at
DNASU PaCD00006742
Entrez 881883
GenBank AAG05012.1
INSDC AAG05012.1
NCBI Locus Tag PA1623
protein_id(GenBank) gb|AAG05012.1|AE004590_3|gnl|PseudoCAP|PA1623
TIGR NTL03PA01624
UniParc UPI00000C5412
UniProtKB Acc Q9I399
UniProtKB ID Q9I399_PSEAE
UniRef100 UniRef100_W0YPX4
UniRef50 UniRef50_P77526
UniRef90 UniRef90_W0YPX4

Product

Feature Type CDS
Coding Frame 1
Product Name
conserved hypothetical protein
Product Name Confidence: Class 4
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -2.04
Kyte-Doolittle Hydrophobicity Value -0.325
Molecular Weight (kDa) 24.9
Isoelectric Point (pI) 6.14

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
6TAH TRANSFERASE 10/29/19 Crystal structure of a Nu-class Glutathione-S-Transferase from Pseudomonas aeruginosa PACS2 bound to glutathione Pseudomonas aeruginosa 1.3 X-RAY DIFFRACTION 98.1
4ECI TRANSFERASE 03/26/12 Crystal structure of glutathione s-transferase prk13972 (target efi-501853) from pseudomonas aeruginosa pacs2 complexed with acetate Pseudomonas aeruginosa 1.8 X-RAY DIFFRACTION 99.5
6TUM TRANSFERASE 01/07/20 Crystal structure of glutathione s-transferase PA1623 from Pseudomonas aeruginosa PACS2 complexed with tartrate Pseudomonas aeruginosa 1.48 X-RAY DIFFRACTION 98.2
4ECJ TRANSFERASE 03/26/12 Crystal structure of glutathione s-transferase prk13972 (target efi-501853) from pseudomonas aeruginosa pacs2 complexed with glutathione Pseudomonas aeruginosa 1.76 X-RAY DIFFRACTION 99.5

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 219 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000995 (896 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1623

Human Homologs

References

Sequence analysis of a gene cluster involved in metabolism of 2,4,5-trichlorophenoxyacetic acid by Burkholderia cepacia AC1100.
Daubaras DL, Hershberger CD, Kitano K, Chakrabarty AM
Appl Environ Microbiol 1995 Apr;61(4):1279-89
PubMed ID: 7538273