Pseudomonas aeruginosa PAO1, PA1649

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1649
Name
Replicon chromosome
Genomic location 1796138 - 1796899 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 5 transposon mutants in orthologs

Cross-References

RefSeq NP_250340.1
GI 15596846
Affymetrix PA1649_at
Entrez 878266
GenBank AAG05038.1
INSDC AAG05038.1
NCBI Locus Tag PA1649
protein_id(GenBank) gb|AAG05038.1|AE004592_9|gnl|PseudoCAP|PA1649
TIGR NTL03PA01650
UniParc UPI00000C5427
UniProtKB Acc Q9I376
UniProtKB ID Q9I376_PSEAE
UniRef100 UniRef100_W0YQD8
UniRef50 UniRef50_D3P0W3
UniRef90 UniRef90_B7UV72

Product

Feature Type CDS
Coding Frame 1
Product Name
probable short-chain dehydrogenase
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Charge (pH 7) -2.47
Kyte-Doolittle Hydrophobicity Value 0.382
Molecular Weight (kDa) 25.8
Isoelectric Point (pI) 5.76

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown (This protein may have multiple localization sites) Class 3
Unknown (This protein may have multiple localization sites) Class 3
Cytoplasmic Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
7DJS OXIDOREDUCTASE 11/21/20 Crystal structure of isopiperitenol dehydrogenase from Pseudomonas aeruginosa complexed with NAD Pseudomonas aeruginosa 1.7 X-RAY DIFFRACTION 98.8

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 652 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000180 (2633 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1649

Human Homologs

Ensembl 110, assembly GRCh38.p14
dehydrogenase/reductase 4 [Source:HGNC Symbol;Acc:HGNC:16985]
E-value: 2.6e-25
Percent Identity: 33.5
Ensembl 110, assembly GRCh38.p14
dehydrogenase/reductase 4 [Source:HGNC Symbol;Acc:HGNC:16985]
E-value: 2.6e-25
Percent Identity: 33.5

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295