Pseudomonas aeruginosa PAO1, PA1775 (cmpX)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1775
Name
cmpX
Replicon chromosome
Genomic location 1919579 - 1920403 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_250466.1
GI 15596972
Affymetrix PA1775_at
DNASU PaCD00006809
Entrez 877590
GenBank AAG05164.1
INSDC AAG05164.1
NCBI Locus Tag PA1775
protein_id(GenBank) gb|AAG05164.1|AE004603_4|gnl|PseudoCAP|PA1775
TIGR NTL03PA01776
UniParc UPI00000D421D
UniProtKB Acc G3XCV6
UniProtKB ID G3XCV6_PSEAE
UniRef100 UniRef100_G3XCV6
UniRef50 UniRef50_G3XCV6
UniRef90 UniRef90_G3XCV6

Product

Feature Type CDS
Coding Frame 1
Product Name
conserved cytoplasmic membrane protein, CmpX protein
Product Name Confidence: Class 1
Synonyms conserved cytoplasmic membrane protein, CmpX
Evidence for Translation
Detected using LC-MS/MS (29.02 kDa, PMID:21751344)
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 0.99
Kyte-Doolittle Hydrophobicity Value 0.983
Molecular Weight (kDa) 29.0
Isoelectric Point (pI) 8.80

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Vesicle Class 1
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 119 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003620 (537 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1775
Search term: cmpX

Human Homologs

References

Influence of a putative ECF sigma factor on expression of the major outer membrane protein, OprF, in Pseudomonas aeruginosa and Pseudomonas fluorescens.
Brinkman FS, Schoofs G, Hancock RE, De Mot R
J Bacteriol 1999 Aug;181(16):4746-54
PubMed ID: 10438740
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa.
Choi DS, Kim DK, Choi SJ, Lee J, Choi JP, Rho S, Park SH, Kim YK, Hwang D, Gho YS
Proteomics 2011 Aug;11(16):3424-9
PubMed ID: 21751344